Splicing of RNA transcripts

In mammalia, seven different members encoded by distinct genes have been identified, all of which are activated by a distinct set of cytokines. Diversity in signaling is provided by variants of STAT proteins derived from either alternative splicing of RNA transcripts or proteolytic processing (e.g., STATs 1,3,4, and 5) and the ability of certain STATs to form both homodimers and heterodimers with each other. In response to inteiferon-y monomeric STAT1 dimerizes, while upon interferon-a stimulation a heterotrimeric complex consisting of STAT 1 and STAT2 with associated... 

A proteome is the complete complement of translation products (i.e., polypeptides and proteins) that can be produced from the code held in an organism s genome. As for a transcriptome, a full proteome will include protein variants produced from individual genes by alternative splicing of RNA transcripts and alternative posttranslational modifications. 

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