Libraries peptide

SI Cho, W Zheng, A Tropsha. Rational combinatorial library design 2. Rational design of targeted combinatorial peptide libraries using chemical similarity probe and the inverse QSAR approaches. J Chem Inf Comput Sci 38 259-268, 1998. 

The Src SH2 domain typifies a large number of those characterized to date. The pTyr fits into a pocket on the opposite side of the central sheet to the pY-r3 pocket (Figure 13.27a). All known SH2 domains bind pTyr in essentially the same way, but some have a different pattern of contacts for the residues that follow. For example, in the Grb2 SH2 domain, a tryptophan side chain from the small sheet fills the pY-r3 pocket, and the bound peptide takes a different course, with important interactions to an asparagine at pY-r2. Screens of peptide libraries have detected the importance of this asparagine. The SH2 domain from PFC-yl contacts five mainly hydrophobic residues that follow pTyr. 

Phage display of random peptide libraries identified agonists of erythropoietin receptor... 

EMPl, selected by phage display from random peptide libraries, demonstrates that a dimer of a 20-residue peptide can mimic the function of a monomeric 166-residue protein. In contrast to the minimized Z domain, this selected peptide shares neither the sequence nor the structure of the natural hormone. Thus, there can be a number of ways to solve a molecular recognition problem, and combinatorial methods such as phage display allow us to sort through a multitude of structural scaffolds to discover novel solutions. 

A mixed 4x4 peptide library consisting of 16 members was again prepared from the earlier-shown two families of building blocks 9-12 (all l enantiomers) and... 

Fig. 18 Peptide library used for studying complementary peptides. Reproduced from Takahashi et al. [57] with permission. Copyright Wiley-VCH...

Folgori, A., Taft, R., Meola, A., Felici, F., Galfre, G., Cortese, R., Monaci, P., and Nicosia, A. (1994). A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J. 13, 2236-2243. 

Pasqualini, R., and Ruoslahti, E. (1996). Organ targeting in vivo using phage display peptide libraries. Nature 380, 364-366. 

Yao, Z.-J., Kao, M. C. C., and Chung, M. C. M. (1995). Epitope identification by polyclonal antibody from phage-displayed random peptide library. J. Protein Chem. 14, 161-166. 

The specificity determinants surrounding the tyrosine phospho-acceptor sites have been determined by various procedures. In PTK assays using various substrates, it was determined that glutamic residues of the N-terminal or C-terminal side of the acceptor are often preferred. The substrate specificity of PTK catalytic domains has been analyzed by peptide library screening for prediction of the optimal peptide substrates. Finally, bioinformatics has been applied to identify phospho-acceptor sites in proteins of PTKs by application of a neural network algorithm. 

Donia, M.S., Hathaway, B.J., Sudek, S. et al. (2006) Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nature Chemical Biology, 2, 729. 

We have previously developed an in vivo selection method in which peptides that home to specific vascular beds are selected after intravenous administration of a phage display random peptide library [5]. This strategy revealed a vascular address system that allows tissue-specific targeting of normal blood vessels [6-8] and angiogenesis-related targeting of tumor blood vessels [3, 6, 9-12]. While the biologi-... 

Naik, R.R., Brott, L.L., Clarson, S.J. and, Stone, M.O. (2002) Silica-precipitating peptides isolated from a combinatorial phage display peptide library. Journal of Nanoscience and Nanotechnology, 2, 95-100. 

Figure 16.4 Graph depicting the percentage of lysine residues among peptides that bind to the indicated monoclonal antibodies. The peptides were isolated after affinity selection (biopanning) from a phage-displayed combinatorial peptide library. The peptides are grouped as to whether they are susceptible to formalin fixation, resulting in a loss of immunoreactivity.

Martin, L.J., Sculimbrene, B.R., Nitz, M., and Imperial/ B. (2005) Rapid combinatorial screening of peptide libraries for the selection of lanthanide-binding tags (LBTs). QSAR Combin. Sci. 24(10), 1149-1157. 

W Beck, G Jung. Convenient reduction of S-oxides in synthetic peptides, lipopeptides and peptide libraries, (trimethylsilyl bromide) Lett Pept Sci 1,31, 1994. 

Riche EL, Erickson BW, Cho MJ. Novel long-circulating liposomes containing peptide library-lipid conjugates synthesis and in vivo behavior. J Drug Target 2004 12 355. 

Pasqualini R, Ruoslahti E. Tissue targeting with phage peptide libraries. Mol Psychiatry 1996 1(6) 423. 

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