Synthesis parallel case

The information that all case item values are mutually exclusive needs to be passed to the synthesis tool. This is done by using a synthesis directive called parallel case. When such a directive is attached to a case statement, a synthesis tool interprets the case statement as if all case items are mutually exclusive. Since the synthesis directive appears as a comment in the Verilog HDL model, it has no effect on the language semantics of the model. This implies that no priority logic is synthesized for the case statement control instead decoding logic is used. Here is the case statement with the parallel case directive. 

A word of caution. The synthesis directive, parallel case, can potentially cause a functional mismatch between the design model and the synthesized netlist Chapter 5 elaborates on this further. 

The two synthesis directives we have seen so far, full case and parallel case, can potentially cause functional mismatches to occur between the design model and the synthesized netlist. The problem is that these directives are recognized only by a synthesis tool and not by a simulation tool. In either of the cases, if the designer is not careful in specifying the directive, mismatches can occur. 

Here is an example of a parallel case synthesis directive. 

Recommendation Use caution when using the synthesis directives full case and parallel case. Use only if really necessary. 

Two distinct strategies of peptide lihrary preparation are commonly used parallel synthesis and so-called sptit-and-mix chemistry (also known as divide-couple- ecom-bine, portion-mixing and split-pool synthesis). Both are often described as combinatorial chemistry (combichem), although this is only strictly true for sptit-and-mix synthesis. Parallel synthesis is simply the preparation of many batches of peptide at the same time in separate parallel channels of one or more machines. In the case of library synthesis, the amino acid sequence is systematically varied between channels. Commonly this allows the synthesis of several hundred different sequences at the same time. It has the advantages that larger amounts are usually prepared than in split-and-mix, and that one can easily tell what sequence of residues was used in any potential hit. 

The major impetus for the development of solid phase synthesis centers around applications in combinatorial chemistry. The notion that new drug leads and catalysts can be discovered in a high tiuoughput fashion has been demonstrated many times over as is evidenced from the number of publications that have arisen (see references at the end of this chapter). A number of )proaches to combinatorial chemistry exist. These include the split-mix method, serial techniques and parallel methods to generate libraries of compounds. The advances in combinatorial chemistry are also accompani by sophisticated methods in deconvolution and identification of compounds from libraries. In a number of cases, innovative hardware and software has been developed tor these purposes. 

Combinatorial Chemistry. Figure 2 Chemical libraries are prepared either by parallel synthesis or by the split-and-recombine method. In the latter case, coupling m building blocks in m separated reaction flasks through n synthetic cycles on a beaded polymer carrier generates a combinatorial library with nf individual compounds and one compound per bead. 

As in the case of benzimidazole, a parallel synthesis of benzoxazoles was described. The authors report that mixing directly differently substituted o-amino phenols 193 with acylating agents 194 and heating at 200 °C for 10-15 min under microwave irradiation, a collection of benzoxazoles 195 was obtained (Scheme 70). With this reaction, a 48-member library of benzoxazoles with different substituents on the aromatic rings was obtained [125]. 

The above-mentioned targets refer to general advantages of micro reactors [42, 80, 100, 114, 119]. Enhanced transfer and better controlled residence time improve conversion and selectivity. The tools have small internal volumes, allowing one to generate flexibly a multitude of samples in serial or parallel fashion. Synthesis can be combined with a multi-step procedure. The economy of micro-reactor processes has not really been analyzed so far however, it is clear that as laboratory tools they allow in a number of cases technical expenditure, personnel and costs to be reduced. 

Current evidence suggests that the cells of the IVD are themselves the primary culprits responsible for the destruction of the IVD ECM via the increased production of numerous proteinases (Table 2) [26, 27, 41, 42]. In most cases, production of tissue inhibitors of MMPs (TIMPs) increases in parallel with MMP synthesis however, TIMP-3 (an inhibitor of ADAMTS-4) may not, thus potentially... 

Other microwave-assisted parallel processes, for example those involving solid-phase organic synthesis, are discussed in Section 7.1. In the majority of the cases described so far, domestic multimode microwave ovens were used as heating devices, without utilizing specialized reactor equipment. Since reactions in household multimode ovens are notoriously difficult to reproduce due to the lack of temperature and pressure control, pulsed irradiation, uneven electromagnetic field distribution, and the unpredictable formation of hotspots (Section 3.2), in most contemporary published methods dedicated commercially available multimode reactor systems for parallel processing are used. These multivessel rotor systems are described in detail in Section 3.4. 

B. M. Glass, A. P. Combs, Case Study 4-6 Rapid Parallel Synthesis Utilizing Micro-wave Irradiation, in High-Throughput Synthesis. Principles and Practices (Ed. I. Sucholeiki), Marcel Dekker, Inc., New York, 2001, Chapter 4.6, pp 123—128. 

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