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Friedel-Crafts reactions synthesis

Barbier-Wieland degradation Boudroux-Chichibabin synthesis Bouveault aldehyde synthesis Darzens synthesis Friedel-Crafts Reaction Gatterman-Koch reaction Grignard reaction Reformatsky reaction Saytzeff reaction Ullmann coupling reaction Wiirtz coupling reaction Wiirtz-Fittig reaction... [Pg.11]

Benzilic acid rearrangement Benzoin reaction (condensation) Blanc chloromethylation reaction Bouveault-Blanc reduction Bucherer hydantoin synthesis Bucherer reaction Cannizzaro reaction Claisen aldoi condensation Claisen condensation Claisen-Schmidt reaction. Clemmensen reduction Darzens glycidic ester condensation Diazoamino-aminoazo rearrangement Dieckmann reaction Diels-Alder reaction Doebner reaction Erlenmeyer azlactone synthesis Fischer indole synthesis Fischer-Speior esterification Friedel-Crafts reaction... [Pg.1210]

Synthesis hote that there is only one activated site for the Friedel-Crafts reaction - o and p to the two methyl groups but not between them for steric reasons ... [Pg.27]

Uses. Aluminum chloride is used as a catalyst in a wide variety of manufacturing processes, such as the polymerization of light molecular weight hydrocarbons in the manufacture of hydrocarbon resins. Friedel-Crafts reactions (qv) which employ this catalyst are used extensively in the synthesis of agricultural chemicals, pharmaceuticals (qv), detergents, and dyes (12). [Pg.148]

Benzimidazolinone, 1,3-dimethyl-Friedel-Crafts reaction, 5, 429 Benzimidazolinone, 1,3-divinyl-synthesis, 5, 393 Benzimidazolinone, 6-methyl-Friedel-Crafts reaction, 5, 429 Benzimidazolin-2-one polymers, 1, 281 Benzimidazolinones alkylation, 5, 390 Friedel-Crafts reaction, 5, 429 Mannich reaction, 5, 390 nitration, 5, 429 reactions, 5, 442... [Pg.539]

Oxazol-5(2H)-one, 2-benzylidene-4-methyl-tautomerism, 6, 186 Oxazol-5(2ff)-one, 2-methylene-isomerization, 6, 226 Oxazol-5(2H)-one, 2-trifluoromethyl-acylation, 6, 201 Oxazol-5(4ff)-one, 4-allyl-thermal rearrangements, 6, 199 Oxazol-5(4H)-one, 4(arylmethylene)-Friedel-Crafts reactions, 6, 205 geometrical isomerism, 6, 185 Oxazol-5(4ff)-one, 4-benzylidene-2-phenyl-configuration, 6, 185 photorearrangement, 6, 201 Oxazol-5(4ff)-one, 4-benzyl-2-methyl-Friedel-Crafts reactions, 6, 205 Oxazol-5(4ff)-one, 4-methylene-in amino acid synthesis, 6, 203 Oxazol-5(4ff) -one. 2-trifluoromethyl-hydrolysis, 6, 206 Oxazolones... [Pg.730]

Beyer synthesis, 2, 474 electrolytic oxidation, 2, 325 7r-electron density calculations, 2, 316 1-electron reduction, 2, 282, 283 electrophilic halogenation, 2, 49 electrophilic substitution, 2, 49 Emmert reaction, 2, 276 food preservative, 1,411 free radical acylation, 2, 298 free radical alkylation, 2, 45, 295 free radical amidation, 2, 299 free radical arylation, 2, 295 Friedel-Crafts reactions, 2, 208 Friedlander synthesis, 2, 70, 443 fluorination, 2, 199 halogenation, 2, 40 hydrogenation, 2, 45, 284-285, 327 hydrogen-deuterium exchange, 2, 196, 286 hydroxylation, 2, 325 iodination, 2, 202, 320 ionization constants, 2, 172 IR spectra, 2, 18 lithiation, 2, 267... [Pg.831]

Quinolin-2-one, 3-cyano-4-hydroxy-synthesis, 2, 428 Quinolin-2-one, 3,4-dialkyl-Knorr synthesis, 2, 425 Quinolin-2-one, dihydro-Camps synthesis, 2, 418 synthesis, 2, 402 from benzazepinones, 2, 506 from indanone oxime, 2, 487 from indanones, 2, 488 by intramolecular Friedel-Crafts reactions, 2, 421... [Pg.832]

Triazin-3-one, 5,6-diphenyI-Friedel-Crafts reaction, 3, 409 mass spectra, 3, 396 synthesis, 3, 441... [Pg.904]

The synthesis of deoxybenzoin from phenacetyl chloride and benzene by the Friedel-Crafts reaction has been described. For symmetrically substituted deoxybenzoins, direct reduction of the readily accessible benzoin is a more convenient method. Reduction of benzoin by zinc dust and acetic acid, and by hydrochloric acid and granulated tin or amalgamated powdered tin has been reported. The present method is based on a publication of the authors. ... [Pg.18]

Thiophenethiols are prepared by reduction of the sulfonyl chlorides or, more conveniently, by the reaction of Grignard rea-gents or thienyllithium compounds with sulfur. They have also been obtained by cleavage or thienyl alkyl sulfides with sodium in liquid ammonia. 3-Thiophenethiol is a by-product in the commercial thiophene synthesis. Thiophenethiols have recently also been prepared by a synthesis involving Friedel-Crafts reaction of 2,4-dinitrobenzenesulfenyl chloride with thiophenes, followed by basic cleavage of the resulting sulfide. ... [Pg.86]

An ingenious synthesis of 1-arylisoindolcs has been developed by Vebor and Lwowski, based upon the reaction of an o-phthalimido-methylbenzophenone (41, R = aryl) with hydrazine (Table IV). The benzophenone is prepared by a Friedel-Crafts reaction with o-phthalimidomethylbenzoyl chloride (40). The mechanism of isoindole formation can be represented sehematically by a sequence involving attack by hydrazine at the imide to give the ring-opened hj drazide (42), followed by cyclization to phthalazine-l,4-dione (44) with displacement of the o-aminomethylbenzophenone (43). Intramolecular condensation of the latter can lead, via the isoindolenine... [Pg.123]

As a demonstration of the complete synthesis of a pharmaceutical in an ionic liquid, Pravadoline was selected, as the synthesis combines a Friedel-Crafts reaction and a nucleophilic displacement reaction (Scheme 5.1-24) [53]. The allcylation of 2-methylindole with l-(N-morpholino)-2-chloroethane occurs readily in [BMIM][PF6] and [BMMIM][PF6] (BMMIM = l-butyl-2,3-dimethylimida2olium), in 95-99 % yields, with potassium hydroxide as the base. The Friedel-Crafts acylation step in [BMIM][PF6] at 150 °C occurs in 95 % yield and requires no catalyst. [Pg.186]

Stamatoff and Wittmann reported a synthesis of a 2-(4-phenoxyphenyl)hexa-duoroisopropanol in the presence of HF and an organic solvent via a Friedel-Crafts reaction, as shown in Scheme 6.29.231 The resulting polymer could be compression molded at 330-350°C. It also exhibited excellent thermostability and mechanical properties. [Pg.361]

Based on petrochemicals, linear alkyl benzene sulfonates (LAS) are the most important surfactants. First description can be found in patents from the mid-1930s [2] using Fischer-Tropsch synthesis and Friedel-Crafts reactions. With the beginning of the 1950s the importance of the class of surfactants rose. The main use is in household and cleaning products. [Pg.502]

After succeeding in the direct synthesis of allyidichlorosilane hy reacting elemental silicon with a mixture of allyl chloride and hydrogen chloride in 1993," Jung el cil. reinvestigated the Friedel-Crafts reactions of benzene derivatives with allyidichlorosilanes in detail (Eq. (2)). [Pg.151]

The FeCls-catalyzed Friedel-Crafts reactions of electron-rich arenes with imines or aziridines provide a facile and convenient route for the synthesis of p-aryl... [Pg.5]

Friedel-Crafts reaction remains unexplored, possibly due to the difficulty of the cycloalkyne formation. A mild, versatile, and efficient method for the one-step synthesis of substituted dihydro- and tetrahydroisoquinolines has been developed by the FeCl3-6H20-catalyzed intramolecular allenylation/cyclization reaction of benzylamino-substituted propargylic alcohols, representing the first example of the intramolecular Friedel-Crafts reaction of propargylic alcohols (Scheme 8) [24, 25]. FeCls, InCls, and Yb(OTf)3 also exhibit good catalytic activity for the reaction. [Pg.7]

In 2000, Takata et al. reported the synthesis of diaryIsulfoximines by the Friedel-Craft reaction of sulfonimidoyl chloride with aromatic compounds in the presence of... [Pg.23]

Scheme 38 Synthesis of diarylsulfoximines by Friedel-Crafts reactions... Scheme 38 Synthesis of diarylsulfoximines by Friedel-Crafts reactions...
There are a number of variations of the Friedel-Crafts reactions that are useful in synthesis. The introduction of chloromethyl substituents is brought about by reaction with formaldehyde in concentrated hydrochloric acid and halide salts, especially zinc chloride.62 The reaction proceeds with benzene and activated derivatives. The reactive electrophile is probably the chloromethylium ion. [Pg.1023]


See other pages where Friedel-Crafts reactions synthesis is mentioned: [Pg.182]    [Pg.351]    [Pg.33]    [Pg.589]    [Pg.662]    [Pg.735]    [Pg.784]    [Pg.833]    [Pg.103]    [Pg.157]    [Pg.100]    [Pg.165]   
See also in sourсe #XX -- [ Pg.2 , Pg.737 ]




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