Total Synthesis of Lignans and Polymeric Resveratrol by Friedel-Crafts Reactions

SCHEME 10.36 Short total synthesis of podophyllotoxin enabled by a Pd-catalyzed C(sp )—H arylation. 

5 TOTAL SYNTHESIS OF LIGNANS AND POLYMERIC RESVERATROL BY FRIEDEL-CRAFTS REACTIONS 

Cyclogalgravin (191) then can be served as a common intermediate for collective synthesis of stereodivergent aryltetralins and aryltetralones [(33, 194-199)] with anti-anti or (anti-)syn-anti arrangement of substituents in tetrahydronaphthalene (THN) skeleton through a series of redox reactions. In particular, the first racemic syntheses of 

SCHEME 1037 Synthetic tactic of 2,7 -cyclolignan class and their correlation. 

SCHEME 10.38 Total synthesis of galbulin and isogalbulin via cyclogalgravin and kadangnstin J. 

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