Sulphate lotion

Normal serum concentrations of zinc are in the range 0.7 to 1.7 ag/ml. Zinc salts are considered to be poisonous, but there appears to be no consensus of opinion on the minimum lethal dose. However, fatalities have been recorded following a dose of as little as 10 g of zinc sulphate. A number of suicides have been attempted with eye lotions containing zinc salts. Zinc derived from galvanised pipes occurs as a contaminant of drinking water. 

Compound Solution of Alum. Rub together 1 ounce each alum and sulphate of zinc dissolve iu 3 pints boiling water. If necessary, filter. This is detergent and astringent, and is used as a lotion for old ulcers, excoriations < c. and, largely diluted with water, as an ere-wash and injection. 

Solution of Amznonio-Sul-phate of Copper, Dissolve 1 drachm of tho ammonio-sulphate in 1 pint water, and filter. This is stimulant and detergent. Ap-pbed as a lotion to indolent ulcers and, largely diluted, to remove specks on tho cornea. Also used as a test for arsenical compounds, with which it throws down a groen precipitate. 

Astringent Lotion. Sulphate of zinc, 2 drachms water, 1 pint camphorated spirit of wine, 2 drachms mixed together. This is an excellent lotion for piles, used night and morning. 

Compound Alum Lotion. A detergent and astringent lotion for old ulcers, chilblains, excoriations, < c., and, largely diluted, as an eye-wash and injection. Dissolve 1 ounce each of alum and sulphate of zinc in 3 pints boiling water filter, if necessary. 

Spackman s Lotion for Inflamed Parta. Mix 1 drachm tincture of myrrh 3 drachms tincture of camphor 1 ounce rectified spirits of wine 1 drachm Goulard s extract 1 ounce solution of sulphate of morphia 2 ounces tincture of arnica, and 4 ounces water. 

Velpeau s Erysipelas Lotion, Dissolve 1 ounce sulphate ot iron in 1 pint water. Apply to tho part affected every 2 or... 

Modes of Application.—Internally —As a cathartic and emetic, dissolved in tepid water. Sometimes half doses of chloride of sodium and sulphate of magnesia are mixed with ginger, pimento, or some other aromatic and treacle such a mixture will often be voluntarily drunk by cattle and sheep. Croton oil, oil of turpentine, and calomel, may be added to common salt, to increase its cathartic and anthelmintic action and mustard, sulphate of zinc, sulphate of copper, or tartarated antimony, may be combined with it to ensure its prompt action as an emetic. As a tonic and stomachic, it should be sprinkled over the animal s food, either in the state of powder or in solution. Externally —A lotion consisting of one pound of common salt dissolved in a gallon of cold water. This lotion should be applied during, or immediately after, the solution of the salt. 

Precipitation or opalescence could occur when the concentration of one of the formulation components is near to its limit of solubility or due to an incompatibility between two formulation components. The appropriate choice of excipients can solve these problems. For example, the addition of citrate to an eye lotion containing zinc sulphate prevents precipitation of zinc hydroxide (see Table 10.2). 

The preparation of green vitriol (ferrous sulphate) from roasted pyrites is described there are three kinds of vitriol, blue (from Cyprus or Hungary, copper sulphate), green (from Spa, etc., ferrous sulphate), and white, sold in small cakes and called in France white copperas (couperose blanche) and used as an eye-lotion (zinc vitriol or zinc sulphate) the best is green vitriol, the blue,... 

Pharmaceutical suspensions are dispersions of solid particles of an insoluble or sparingly soluble drug in a liquid vehicle, usually water [33, 34]. Several examples of pharmaceutical suspensions are used Oral Suspensions, antibiotic preparations, antiacid and clay suspensions, radioopaque suspensions, barium sulphate suspensions. The vehicle is syrup, sorbitol solution or gum thickener with added artificial sweetener. Topical suspensions (externally applied shake lotion ) such as calamine lotion USP are also formulated as suspensions. Several dermatological preparations are also used in pharmacy. 

Compound Eye Lotion of Zinc Sulphate, B.P.C. A solution of boric acid, 2 29 per cent and zinc sulphate, 0 34 per cent in purified water. 

Lotion of Copper and Zinc Sulphates, B.P.C, This preparation contains 0-914 per cent of copper sulphate and 1-37 per cent of zinc sulphate dissolved in camphor water. 

The B,P.C. eye-drops and eye lotions are simple solutions of zinc sulphate with one or more of the following substances sodium chloride, adrenaline solution, chlorbutol and boric acid. None of these substances interferes with the assay of zinc sulphate by EDTA titration, method (viii) a)y 1 ml 0 02M EDTA = 0-00575 g ZnS04,7H20 adrenaline solution tends to mask the end-point but the amount present in these preparations is not sufficient to prevent the end-point being readily detected. For titration take 30 ml of Eye-drops of Zinc Sulphate B,P.C. (0-25 per cent), 30 ml of Eye-drops of Zinc Sulphate and Adrenaline, B.P.C. (0-25 per cent), and 50 ml of Compound Eye Lotion of Zinc Sulphate, B.P,C, (0-34 per cent with 2 29 per cent of boric acid) if boric acid is to be determined in the last-mentioned preparation, the zinc must first be precipitated with sodium carbonate (see p. 134). 

Lotion of Zinc Sulphate, B.P.C. Contains 1 per cent of zinc sulphate. 

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