Sorbitol Solution

Sterile aqueous D-sorbitol solutions are fermented with y cetobacter subo >gichns in the presence of large amounts of air to complete the microbiological oxidation. The L-sorbose is isolated by crystallisation, filtration, and drying. Various methods for the fermentation of D-sorbitol have been reviewed (60). A.cetobacter suboyydans is the organism of choice as it gives L-sorbose in >90% yield (61). Large-scale fermentations can be carried out in either batch or continuous modes. In either case, stefihty is important to prevent contamination, with subsequent loss of product. 

Orally administered suspensions containing a wide class of active ingredients (e.g., antibiotics, antacids, radiopaque agents) are of major commercial importance. The solids content of an oral suspension may vary considerably. For example, antibiotic preparations may contain 125-500 mg solid drug per 5 mL or a teaspoonful dose, while a drop concentrate may provide the same amount of drug in only 1-2 mL. Antacid or radiopaque suspensions also contain relatively high amounts of suspended material for oral administration. The suspending vehicle can, for example, be a syrup, sorbitol solution, or gum-thickened water with added... 

How many milliliters of a 64% (w/w) sorbitol solution having a specific gravity 1.26, should be used in preparing a liter of a 10% (w/v) solution ... 

The sorbitol solution produced from hydrogenation is purified in two steps [4]. The first involves passing the solution through an ion-exchange resin bed to remove gluconate and other ions. In the second step, the solution is treated with activated carbon to remove trace organic impurities. The commercial 70% sorbitol solution is obtained by evaporation of the water under vacuum. The solid is prepared by dehydration until a water-free melt is obtained which is cooled and seeded. The crystals are removed continuously from the surface (melt crystallization). The solid is sold as flakes, granules, pellet, and powder forms in a variety of particle size distributions. 

The compendial tests given here are for sorbitol solid. Separate tests for sorbitol solution USP are listed separately in The National Formulary [34]. 

Sorbitol solution is prepared by dissolving the following materials in water and then autoclaved 1 M Sorbitol, 10 mM EDTA. 

Charge the sorbitol solution and 20% of item 5 in a mixing vessel. 

FD C red no. 40, FD C yellow no. 6, flavor, glycerin, purified water, sorbitol solution, and sucrose. 

Add sorbitol solution and citric acid (item 4) while mixing. 

Add sorbitol solution (item 4) and 80 mL of purified water (item 14) and heat with mixing to 60° to 70°C until the xanthan gum is fully dissolved. 

Add sorbitol solution and mix well. Raise the temperature, if necessary, maintaining temperature at 85° to 90°C. 

In a separate container charge propylene glycol and sorbitol solution. Add carboxymethyl cellulose and aerosol homogenizes and store for a few hours. 

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