Shake lotions

Eye Contact Wash eyes immediately with copious amounts of water for at least 15 min apply an ophthalmic corticosteroid ointment after decontamination treat delayed erythema with a bland shake lotion (such as calamine lotion) or a topical corticosteroid depending on severity do not wear contact lenses when working with this chemical seek medical attention immediately. 

Topical suspensions are intended to be applied externally. Shake lotion and calamine lotion are good... 

Shake lotions, e.g. calamine lotion, are essentially a convenient way of applying a powder to the skin (see Dusting powders, p. 301) with additional cooling due to evaporation of the water. They are contraindicated when there is much exudate because crusts form. Lotions, after evaporation, sometimes produce excessive drpng of the skin, but this can be reduced if oils are included, as in oily calamine lotion. 

The majority of antipruritic preparations are shake lotions, which besides having such active ingredients as have been mentioned, may contain allergenic fragrances and preservatives. Zinc oxide, often added because of its cooling effect on the skin is completely non-sensitizing but can produce black dermographia in the presence of jewelry. 

Pharmaceutical suspensions are dispersions of solid particles of an insoluble or sparingly soluble drug in a liquid vehicle, usually water [33, 34]. Several examples of pharmaceutical suspensions are used Oral Suspensions, antibiotic preparations, antiacid and clay suspensions, radioopaque suspensions, barium sulphate suspensions. The vehicle is syrup, sorbitol solution or gum thickener with added artificial sweetener. Topical suspensions (externally applied shake lotion ) such as calamine lotion USP are also formulated as suspensions. Several dermatological preparations are also used in pharmacy. 

Calamine is basic zinc carbonate that owes its pink colour to added ferric oxide. It has a mild astringent action and is used as a dusting powder and in shake and oily lotions. It is of limited value. 

Cam] orated Lotion. Diluted solution of diacetate of lead, 8 fluid ounces spirit of camphor, 2 drachms mix, and shake well. Refrigerant and anodyne. Employed in erysipelatous infiammations, bums, contusions, sprains, excoriations, c. 

Valuable Lotion for Wounds. Ac. Camphor, 5 drachms, cut into small pieces, and dissolved in half a pint of spirits of wine in a closely corked bottle when fully dissolved, add 4 pint of ox-gall and 60 drops of lanrlanniTi. Shake H well, and bottle lor use. This has been a patent medicine, and is very efftcocionsinthe cure of fresh wounds. 

Suspensions are heterogeneous, nonuniform mixtures containing very large particles that are trapped by filters and do not pass through semipermeable membranes. If you stir muddy water, it mixes but then quickly separates as the suspension particles settle to the bottom. Before you use suspensions such as Kaopectate, calamine lotion, antacid mixtures, and liquid penicillin, it is important that you shake well before using to suspend all the particles they contain. 

Sample preparation Dissolve lotion containing 50 mg oxiconazole in 50 mL MeOH, dilnte a 5 mL aliqnot to 50 mL with mobile phase, inject an ahquot. Shake cream containing 50 mg oxiconazole with 50 mL chloroformiMeOH 50 50 for 30 min (Caution Chloroform is a carcinogen ), make np to 100 mL with MeOH, centrifuge at 4000 rpm at 4° for 15 min, filter, dilnte fivefold with MeOH. 

Lotions, Ointments Weigh an amount of sample equivalent to about 10 mg of neomycin base into a 500-ml flask containing 100 to 150 ml of hot citric-hydrochloric acid solution. Allow to cool, and shake for five minutes. Then add 4 g of Celite, swdrl and filter with gentle suction through a Whatman No. 40 filter paper covered with 2 to 3 g of Celite in a Buchner funnel. Wash the filter with about 200 ml of water and adjust the pti of the combined filtrate and w ashings to 4 0 by the addition of sodium bicarbonate powder. 

Dissolve 0 5 g of lotion containing 0 2 per cent of chlorocresol in sufficient 72 per cent ethanol (prepared from industrial methylated spirit that has been refluxed for four hours over potassium hydroxide and distilled) to make exactly 50 ml. Shake well, chill in ice-water and filter. Pipette 10 ml of the filtrate into a 20-ml graduated flask and dilute to 12 ml with the 72 per cent ethanol. Add 2 ml of a 0 012 per cent solution of 2,6-dichloro-p-benzoquinone-4-chloroimine in 95 per cent ethanol (refluxed and distilled as above) and 2 ml of a 1 5 per cent aqueous borax solution, mixing after each addition. Allow to stand in the dark for one hour and then dilute to volume with the 72 per cent ethanol. Mix and measure the extinction at 650 m/U in a 2-cm cell subtract the value of a reagent blank and read off the amount of chlorocresol from a calibration curve. 

---