Structure and activity

Volume 67 Structure-Activity and Selectivity Relationships in Heterogeneous Catalysis. 

Pedersen, O. M. (1985). Human Risk Contributions in the Process Industry Guides for their Pre-Identificationx in Well-Structured Activities and for Post-Incident Analysis. Report No. RIS0-M-2513, Riso National Laboratories, Roskilde, Denmark. 

Kunkel, E. J., Plavec, L, Nguyen, D., Melrose, J., Rosier, E. S., Kao, L. T., Wang, Y., Hytopoulos, E., Bishop, A. C., Bateman, R., et al. (2004). Rapid structure-activity and selectivity analysis of kinase inhibitors by Bio Map analysis in complex human primary cell-based models. ASSAY Drug Dev. Technol. 2 431-441. 

Henkle-Duhrsen, K., Eckelt, V.H., Wildenburg, G., Blaxter, M. and Walter, R.D. (1998) Gene structure, activity and localization of a catalase from intracellular bacteria in Onchocerca volvulus. Molecular and Biochemical Parasitology 96, 69-81. 

It is the sequence and types of amino acids and the way that they are folded that provides protein molecules with specific structure, activity, and function. Ionic charge, hydrogen bonding capability, and hydrophobicity are the major determinants for the resultant three-dimensional structure of protein molecules. The a-chain is twisted, folded, and formed into globular structures, a-helicies, and P-sheets based upon the side-chain amino acid sequence and weak intramolecular interactions such as hydrogen bonding between different parts of the peptide... 

The interaction of microwaves with solid materials has proven attractive for the preparation and activation of heterogeneous catalysts. It has been suggested that micro-wave irradiation modifies the catalytic properties of solid catalysts, resulting in increasing rates of chemical reactions. It is evident that microwave irradiation creates catalysts with different structures, activity, and/or selectivity. Current studies document a growing interest in the preparation of microwave-assisted catalysts and in the favorable influence of microwaves on catalytic reactions. 

Burr SA, Ray DE (2004) Structure-activity and interaction effects of 14 different pyrcthroids on voltage-gated chloride ion channels. Toxicol Sci 77 341-346... 

VIII. Synopsis The Structure, Activity, and Function of Lipid A... 

Accordingly, sorption has received a tremendous amount of attention and any method or modeling technique which can reliably predict the sorption of a solute will be of great importance to scientists, environmental engineers, and decision makers (references herein and in Chaps. 2 and 3). The present chapter is an attempt to introduce an advanced modeling approach which combines the physical and chemical properties of pollutants, quantitative structure-activity, and structure-property relationships (i. e., QSARs and QSPRs, respectively), and the multicomponent joint toxic effect in order to predict the sorption/desorp-tion coefficients, and to determine the bioavailable fraction and the action of various organic pollutants at the aqueous-solid phase interface. 

Quantitative Structure-Activity and Structure-Property Relationships... 

Zeolite Beta Structure, Activity, and Selectivity for Catalytic Cracking... 

Domine, D., Devillers, J., Chastrette, M., and Karcher, W. (1993). Non-linear mapping for structure-activity and structure-property modeling. J. Chemometrics 7, 227-242. 

Rohrbaugh, R. H. and Jurs, P. C. (1987) Descriptions of molecular shape applied in studies of structure/activity and structure/property relationships. Anal. Chim. Acta 199, 99-109. 

N. Asano, Naturally occurring iminosugars and related alkaloids Structure, activity and applications, in P. Compain and O. R. Martin, (Eds.), Iminosugars From Synthesis to Therapeutic Applications, Wiley, Chichester, 2007, pp. 7-24. 

Pranzatelli MR Benzodiazepine-induced shaking behavior in the rat structure-activity and relation to serotonin and benzodiazepine receptors. Exp Neurol 104 241-250, 1989... 

B. Notari, in Structure-Activity and Selectivity Relationship in Heterogeneous Catalysis, Studies in Surface Science and Catalysis, Vol. 67, R. K. Grasselli and A. W. Sleight, eds., Elsevier, Amsterdam, 1991, p. 243. 

Lorand, L. (2001). Factor XIII Structure, activation, and interactions with fibrinogen and fibrin. Ann. NY Acad. Sci. 936, 291-311. 

These reports have accelerated research investigations into improving the asymmetric alkylation of 1 in terms of catalytic activity and stereoselectivity, the result being the emergence of a series of appropriately modified cinchona alkaloid-based catalysts. The performance of the representative monomeric catalysts in the asymmetric benzylation and allylation of 1 are summarized in Table 2.1, in order to provide an overview of the relationship between the structure, activity and enantioselectivity. 

---