PG Structure and Biological Activities

IPG-P [63-65], less compositional information is available and its metabolic origin remains undefined. 

The design and use of insuUn-like molecules acting downstream insuhn receptor might be useful in treating insuhn-resistance states in this context, IPG is a good candidate molecule as an alternative to insuhn treatment The abihty of IPG to mimic insuhn actions is certainly striking. Tab. 6.2 summarises insuhn-hke effects of IPG on both intact ceUs and cellular extracts [2-5, 8, 10, 32, 34, 72-74]. 

The biological effects of IPG include tissue-specific regulation of lipolysis, lipogen-esis, glycolytic flux, protein synthesis and/or phosphorylation, DNA and RNA synthesis and also long-term actions such as cellular prohferation. IPG-P activates glycerol-3-phosphate acyl transferase [17], but almost aU the other insulin-mimetic activities reported were tested for IPG-A prepared in vitro by hydrolysis of highly purified GPI [1, 7, 8, 75, 76]. 

Biological activity Effect Enzymatic activity Effsct 

Glucose transport Stimulation/ Glucose-6-phosphatase Inhibition 

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