Human complexes

MOF Males-absent on the first. A MYST family HAT subunit of the Drosophila MSL dosage-compensation complex and a highly homologous human complex. 

ACF ISWI Drosophila AcH [59] ISWI is essential for Drosophila development. Most ISWI protein does not co-localize with RNA polymerase [233], but the function of the Drosophila ACF complex in vivo is not clear. However, the equivalent human complex appears to function in DNA replication (see below). 

Thus we have a straightforward example of the application of scientific procedure of the sort originally used to prove the existence of psi phenomena. We went from a stage of anecdote and crude experimentation to sophisticated experimentation that gave us precise information in which we could put great confidence. Now let us look at some of the human complexities that frequently enter into the scientific process in general and into parapsychological research. 

Cardon LR, Abecasis GR. Using haplotype blocks to map human complex trait loci. Trends Genet 2003 19 135-140. 

Visch HJ, Rutter GA, Koopman WJ, Koenderink JB, Verkaart S, de Groot T, Varadi A, Mitchell KJ, van den Heuvel LP, Smeitink JA, Willems PH. Inhibition of mitochondrial Na -I--Ca exchange restores agonist-induced ATP production and Ca + handling in human complex I deficiency. J. Biol. Chem. 2004 279 40328-40336. 

Primary (Genetic) Elevation. EL mice have a Cp gene duplication that results in elevated Cp levels by both immrmochemical and copper oxidase methods of assay. Affected mice have an epileptic disorder similar to human complex partial seizures, possibly because of Cp-induced... 

EXAMPLE 10.19 Human complex I contains 35 proteins. Key hydrogen and electron-transporting proteins within the complex contain the heme rings, copper atoms, and iron atoms. 

OXPHOS, oxidative phosphorylation NDUF, nuclear-encoded subunits of human complex I Fp, flavoprotein ANT, adenine nucleotide translocase SCO, synthesis of cytochrome c oxidase (assembly gene) COX, cytochrome c oxidase. 

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