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Structural Modifications of Glycopeptide Antibiotics and Structure Activity Relationship SAR Studies

8 STRUCTURAL MODIFICATIONS OF GLYCOPEPTIDE ANTIBIOTICS AND STRUCTURE ACTIVITY RELATIONSHIP (SAR) STUDIES [Pg.49]

The SARs of glycopeptide antibiotics have mostly been studied with vancomycin and teicoplanin. Some other examples also comprise the glycopeptides eremomycin, baMmycin, ristocetin, and avoparcin. The reasons for the predominance of vancomycin and teicoplanin are that, particularly vancomycin (Vancomycin, Eli Lilly and Company) and teicoplanin (Targocid, Lepetit, Italy), are industrial large-scale fermentation products, and most of these studies were performed within research programs or with the participation of researchers from Eli Lilly and Lepetit. [Pg.49]




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Activity, SAR

Antibiotic activity

Antibiotics structures

Glycopeptide

Glycopeptide, relationship

Glycopeptides

Modification structure

Modifications of Glycopeptide Antibiotics

Of antibiotics

SAR studies

SARS

Structural modifications

Structure - activity relationships SARs)

Structure SAR

Structure activity relationship (SAR

Structure activity, and

Structure-Activity Relationship (SAR) Studies

Structure-activity relationships, studies

Structure-activity studies

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