Structure and Biological Activity

The problem of understanding the mechanisms of action of estrogens is a difficult one for several major reasons. First, estrogenic activity is asso- 

Estrogenic activity is a property of many types of natural and synthetic compounds. First and foremost are the naturally occurring steroidal estrogens and the related compounds prepared in the laboratory (I, II, III), 

This sharing of a biological activity by chemical compounds of many structural types is somewhat reminiscent of the situation with carcinogens. Agents as different as ionizing radiation, inorganic ions, polycyclic aromatic hydrocarbons, and azo dyes have the common property of setting in motion a chain of biochemical events which leads to the development of a tumor. 

Structural specificity of estrogenic substances has, in addition, several important biological components. The first is the situation in which com- 

Considerable attention has been given to the concept that hormones exert their effects by acting in some way upon enzyme systems. In general, two principal modes of action have been considered. In the first, it is thought that the hormones function as activators or inhibitors of enzymatic reactions, and in the second view, the hormones are considered as active participants in enzymatic reactions. In the first case, the hypothesis is a 

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The held of marine natural products chemistry, which encompasses the study of the chemical structures and biological activities of secondary metabolites produced by marine plants, animals, and microorganisms, began in earnest in the early 1960s. " This is in stark contrast to the study of terrestrial plant natural... 

As described above, the chemistry of 1,2-dithietaiies is far from being developed. Tlierefore, development of excellent synthetic methods of 1,2-dithietanes is truly desired in order to understand their intrinsic nature associated with chemical reactivities, structure, and biological activities. 

Equilibrium, Structural and Biological Activity Studies on [Organotin(IV)]" Complexes... 

Rationalization of the results obtained in the substitution reactions prompted their application to topics of current interest, such as studies on the structures and biological activities of peptides, depsi-peptides, pseudo-peptides, or C2-symmetric... 

Gambari R, Lampronti I, Bianchi N, Zuccato C, Viola G, Vedaldi D, Dall Acqua F (2007) Structure and Biological Activity of Furocoumarins. 9 265-276 Garg R, Bhhatarai B (2006) QSAR and Molecular Modeling Studies of HIV Protease Inhibitors. 3 181-272... 

J. N. Ladd, Foster, P. Nannipieri, and J. M. Oades, Soil structure and biological activity Soil Biochemistry Volume 9 (G. Stotzky and J. M. Bollag, eds.), Marcel Dekker. New York, 1996, pp. 23-78. 

L. Cardenas, J. Dominguez, C. Quinto, 1. Lopez-Lara, B. Lugtenberg, H. Spaink, G. Radeniaker, J. Haverkamp, and J. Thomas-Oates, Isolation, chemical structures and biological activity of the lipo-chitin oligosaccharide nodulation signals from Rhizobium etii. Plant Mol. Biol. 29 453 (1995). 

Chemical Structures and Biological Activity of Natural Diterpene QMs... 

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