Relationships between Chemical Structure and Biological Activity

The relationship between chemical structure and biological activity. 

Precise investigation on the relationship between chemical structures and biological activities, and elucidation of minimum structural requirements for the activities. 

Yoshiki Y, Kodon S and Okubo K (1998) Relationship between chemical structures and biological activities of triterpenoid saponins from soybean. Biosci Biotechnol Biochem 62, 2291-2199. 

J.S. Wasson, Use of Selected Toxicology Information Resources in Assessing Relationships between Chemical Structure and Biological Activity, Environmental Health Perspectives, 61, (1985) 287-294. 

Yoshiki Y, Kudou S, Okubo K (1998) Relationship Between Chemical Structures and Biological Activities of Triterpenoid Saponins from Soybean (Review). Biosci Biotechnol Biochem 62 2291... 

In this chapter, a rationale of the structure-activity relationships of various series of bioactive secondary metabolites from Indo-Pacific marine invertebrates is reviewed. These include alkaloids, terpenes and polybrominated diphenyl ethers which were subjected to a series of bioassays in search for insecticidal, antibacterial, fungicidal, and cytotoxic lead compounds. From these various biotests, it was observed that the bioactivity of an analogue is not due to general toxicity but rather possesses a degree of specificity on a particular target biomolecule. The relationship between chemical structures and biological activity is related to the specific action of a compound. 

Corwin Hansch initiated QSAR and he contributed the most to its development. Correspondingly, this book is dedicated to him on the occasion of his TS anniversary in October 1993. He taught us how to apply QSAR in a proper manner to gain more insight into structure-activity relationships and biological mechanisms. The one and only way to thank him is to feel responsible to use and to develop the QSAR discipline in his sense. Thus, the book shall also be understood as a stimulus to further research on the real relationships between chemical structures and biological activities. 

Relationships between Chemical Structure and Biological Activity... 

P. JoLLES, Relationship between Chemical Structure and Biological Activity of Hen Egg-white Lysozyme and Lysozymes of Different Species, Proc. R. Soc. [B] 167, 350 to 364 (1967). 

Abstract A thorough antimicrobial review of an increasing number of reports reveals a broad spectrum of research activity in the development practices that are used to treat a variety of diseases. The quantitative relationship between chemical structure and biological activity has received considerable attention in recent years because it allows one to predict theoretically bioactivity without an inordinate amount of experimental time and effort. In this chapter we collect and discuss critically published results concerning the QSAR research on antimicrobial compounds. Finally, we present an updated perspective about the future trends in this area. 

The quantitative relationship between chemical structure and biological activity has received considerable attention in recent years because it allows one to predict theoretically bioactivity without an inordinate amount of experimental time and demanding efforts. 

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