Strobilurins systemicity

Azoxystrobin is a synthetic analog of naturally occurring strobilurins and oudemansins. The preventative, curative, eradicant, translaminar and systemic properties facilitate control of a wide range of major plant pathogens in many crops... 

Strobilurin A, Strobilurin and Myxothiazole new inhibitors of the bci segment of the respiratory chain with an ( )-/l-methoxyacrylate system as common structural elements , FEBS Lett., 1981,132, 329-333. 

Fluoxastrobin (Fandango , Bariton ) [211-213], a new strobilurin fungicide with curative and leaf-systemic activity, was developed by Bayer CropScience, for use as both a seed treatment and a foliar spray to treat a variety of diseases in cereals. Fluoxastrobin initially was submitted for registration as an (E)/(Z) isomer mixture and later changed to the (E)-isomer. 

In the nineties a new compound class, the strobilurins, was introduced into the market. In Europe azoxystrobin and kresoxim-methyl were heavily used in cereals and the established product concepts and treatment systems had to be adjusted. Namely the importance of anti-resistance management (ARM) was recognized as a key factor in managing crop treatments and product portfolios. Therefore, contrary to first assumptions, product classes like the morpholines were not substituted directly by this new chemistry, but added as a complement to new product combinations to suppress resistance build vp. 

Azoxystrobin or Methyl (E)-2- 2-(6-(2-cyanophen oxy) pyrimidin-4-yloxy]phenyl -3-methoxyacrylate Strobilurin respiration by blocking electron transfer between cytochromes, systemic with protective action Control of a wide range of pathogens on cereals, vines, potato, rice, fiuits, nuts, and so on 11-32... 

The potent in vitro antifungal activities of strobilurin A were not maintained in the field due to the labile nature of its triene system. Several agricultural firms are engaged in synthetic efforts to produce stable and more potent analogues as potential products. In 1996, two products, amistar and kresoxim methyl, were approved as agricultural fungicides in the U.S. after more than a decade of research and development. 

Shionogi pursued a quite different approach to strobilurins. Their starting point for optimisation was a carbamoylisoxazole screening hit with antifungal activity against rice pathogens. Variations of the isoxazole system led to a development compound in close structural proximity to the strobUurin scaffold (Fig. 8.21). 

Many systemic fungicides, e.g. a triazole, strobilurin or SDHI mixture... 

Apply systemic fungicides, some triazole/SDHI and triazole/ strobilurin mixtures are very effective... 

During the recent decades, capillary GC with different sensitive and/or selective detectors has been the most common tool for the multiresidue determination of pesticides in foods. Among these GC systems, the multi-channel mass spectrometer has superseded the element-selective detectors such as BCD and FPD for some years. However, the thermolabile and/or involatile pesticides still remained unavailable for the GC/MS method. On the other hand, it was obvious that the LC/MS suites for such relatively high-polar pesticides. Therefore we developed a MRM using LC/MS which enabled to analyze a total of 50 pesticides consisting of 11 categories (benzoylurea, carbamate, dicarboximide, neonicotinoid, organophosphosphate, oxim carbamate, pyazole, strobilurin, triazole, urea and the others). 

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