Kresoxime-methyl

EC Directive including the active substance kresoxim-methyl in Annex I of 91/414/EEC concerning... 

Another successful adaptation of the fully extended DFG S19 approach is the determination of, e.g., fenpyroximate in all type of berries by LC/MS/MS with APCI monitoring of positive ions directly in the S19 raw extract, and further the determination of trifluralin by LC/MS/MS with APCI monitoring of negative ions after performing a short SPE cleanup on an ion-exchange material. Similar approaches have used CC/MS/MS for, e.g., fenpropimorph and kresoxim methyl in St. John s Wort and peppermint. 

Changes in catecholamines and 3-O-methyl metabolite concentrations in human plasma Erythropoietin in pharmaceutical products 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine, amphetamine, and methamphetamine in rat urine Azoxystrobin, kresoxim-methyl, and trifloxystrobin fungiddes ... 

De Melo Abreu, S., Correia, M., Herbert, P, Santos, L., and Alves, A., Screening of grapes and wine for azoxystrobin, kresoxim-methyl and trifloxystrobin fungicides by HPLC with diode array detection. Food Additives and Contaminants 22(6), 549-556, 2005. 

III of mitochondrial respiration.14 The compounds exhibited good broad-spectrum activity in vitro, comparable with synthetic standards, but in vivo was inadequate to justify further development as a fungicidal product. Further study showed that activity was lost due to photolytic instability, and led to the production (Figure 4.24) of a series of analogues and selection of the eventual product candidates kresoxim-methyl (BAS 490 F)15 and azoxystrobin (ICIA5504).16... 

Kresoxim-methyl is based on the same strobilurin A lead compounds in which variations of the methoxyacrylate moiety produced the methoxyiminoacetate pharmacophore. 

Kresoxim-methyl BASF Strobilurin type. (Strobilurin)... 

Soil. Rapidly degraded. In soil, DT90 (lab.) <3 days, the main metabolite is the corresponding acid. Very mobile in soil. However, in lysimeter studies, only low levels of kresoxim-methyl and its metabolite were found in leachates... 

In the nineties a new compound class, the strobilurins, was introduced into the market. In Europe azoxystrobin and kresoxim-methyl were heavily used in cereals and the established product concepts and treatment systems had to be adjusted. Namely the importance of anti-resistance management (ARM) was recognized as a key factor in managing crop treatments and product portfolios. Therefore, contrary to first assumptions, product classes like the morpholines were not substituted directly by this new chemistry, but added as a complement to new product combinations to suppress resistance build vp. 

SYNS BENZENEACETIC ACID, a-(METHOXYIMINO)-2-((2-METHYLPHENOXY)METHYL)-, METHYL ESTER, (a-E)- KRESOXIM-METHYL KRESOXIM-METHYL TECHNICAL... 

The strobilurins are an important new class of agricultural fungicides. The best examples exhibit an extremely useful spectrum of activity against many plant diseases of commercial importance. The first two products of this class, azoxystrobin and kresoxim-methyl, first sold just three years ago in April 1996, have already made a major impact on the global fungicide market. The importance of the strobilurins will increase in die years ahead as the established products are registered for use on further crops and in further territories, and as new products, currently under development, are launched. 

Figure 4 The commercial synthetic agricultural fungicides azoxystrobin and kresoxim-methyl, inspired by the natural strobilurins, such as strobilurin A and oudemansin A...

Cyprodinil, fludioxonil, pyrimethanil, tebuconazole, azoxystrobin, fluazinam, kresoxim-methyl, mepanipyrim, and tetraconazole in grapes, must, and wine organic extracts are determined by GC/MS-SIM analysis with LODs of 0.05mg/kg for cyprodinil, pyrimethanil, and kresoxim-methyl, and O.lOmg/kg for the other analytes (Cabras et al.,... 

Cabras, P., Angioni, A., Garau, V.L., Firisi, F.M., and Brandolini, V. (1998). Gas chromatographic determination of azoxystrobin, fluazinam, kresoxim-methyl, mepanipyrim and tetraconazole in grapes, must and wine, J. AOAC Int., 81(6), 1185-1189. 

Strobilurins Strobilurus lenacellus Amistar and kresoxim methyl, agricultural fungicides... 

The potent in vitro antifungal activities of strobilurin A were not maintained in the field due to the labile nature of its triene system. Several agricultural firms are engaged in synthetic efforts to produce stable and more potent analogues as potential products. In 1996, two products, amistar and kresoxim methyl, were approved as agricultural fungicides in the U.S. after more than a decade of research and development. 

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