Renal fibrosis

Polycystic kidney disease (Polycyst in-1 activates canonical Wnt signaling pathway) Injury-induced renal fibrosis Heart failure Ulcerative colitis Osteoporosis-Pseudoglioma Syndrome (genetic syndrome of defective bone formation) Ulcerative colitis Familial Alzheimer s disease (through interaction with Presenilin-1) Familial Alzheimer s disease (through interaction with Presenilin-1)... 

Anders HJ, Vielhauer V, Frink M, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002 109 251-259. 

Liu Y. Renal fibrosis New insights into the pathogenesis and therapeutics. Kidney Int 2006 69(2) 213-217. 

Wada T, Furuichi K, Sakai N, et al. Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. J Am Soc Nephrol 2004 15(4) 940-948. 

Mesangial cells IgA (asialo) Anti- Thyl-Ab Rat Rat, man Renal fibrosis... 

J. Vanherwegheum. 1993. Rapidly progressive interstitial renal fibrosis in young women association with slimming regimen including Chinese herbs. Lancet 341 387-391. 

Terada, Y., Hanada, S., Nakao, A., Kuwahara, M., Sasaki, S. and Marumo, F. (2002). Gene transfer of Smad7 using electroporation of adeno virus prevents renal fibrosis in post-obstructed kidney. Kidney Int. Suppl. 61 (Suppl. 1), 94-98. 

Yang, J., Dai, C. and Liu, Y. (2001). Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice. Gene Ther. 8, 1470-1479. 

Kushibiki, T., Nagata-Nakajima, N., Sugai, M., Shimizu, A., and Tabata, Y. (2005) Delivery of plasmid DNA expressing small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis. Journal of Controlled Release 105 318-331. 

Ishidoya et al. (1995), Klahr and Morrissey (1997) induced interstitial renal fibrosis by unilateral ureteral obstruction in Sprague Dawley rats and tested the effect of ACE inhibitors and angiotensinll receptor antagonists. 

Aristolochic acid is a potent carcinogen and can cause serious kidney damage, Chinese herb nephropathy, which can be fatal (10). Renal fibrosis has also been reported (11). 

Anonymous. Aristolochic acid. Warning concerning interstitial renal fibrosis. WHO Newslett 2000 2 1. 

Nishimagi E, Kawaguchi Y, Terai C, Kajiyama H, Hara M, Kamatani N. Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome. Intern Med 2001 40(10) 1059-63. 

Jacobson SH, Jaremko G, Duraj FF, Wilczek HE. Renal fibrosis in cyclosporin A-treated renal allograft recipients morphological findings in relation to renal hemodynamics. Transpl Int 1996 9(5) 492-8. 

Pena JM, Borras M, Ramos J, Montohu J. Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 1996 ll(7) 1359-60. 

Vanherweghem JL, Abramowicz D, Tielemans C, Depierreux M. Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis a pilot study in Chinese herbs nephropathy. Am J Kidney Dis 1996 27(2) 209-15. 

Ng YY, Yu S, Chen TW, Wu SC, Yang AH, Yang WC. Interstitial renal fibrosis in a young woman association with a Chinese preparation given for irregular menses. Nephrol Dial Transplant 1998 13(8) 2115-17. 

Extensive expression of KlM-1 has been found in proximal tubule cells in biopsies from patients with acute tubular necrosis [302]. KlM-1 is also expressed in other conditions where proximal tubules are dedifferentiated, including renal cell carcinoma [303, 304], chronic cyclosporine nephrotoxicity [305], a protein-overload model of tubulointerstitial disease [306], polycystic kidney disease [307], and contrast nephropathy. In several chronic conditions, KlM-1 has been found primarily expressed at the luminal side of dedifferentiated proximal tubules, in areas with fibrosis and inflammation. Independent of the specific disease, renal KIM-1 correlated positively with the extent of renal damage and negatively with renal function. In these patients, urinary levels of KIM-1 were and correlated positively with tissue KIM-1 and negatively with renal function. Thus, KIM-1 is upregulated in renal disease and is associated with renal fibrosis and inflammation. Urinary KIM-1 is also associated with inflammation and renal function, and reflects tissue KIM-1. 

Short-term pirfenidone and spironolactone treatment was recently found to reverse cardiac and renal fibrosis and to attenuate increased diastolic stiffness without normalizing cardiac contractility or renal function in STZ-diabetic rats [402]. 

Miric G, Dallemagne C, Endre Z, Margolin S, Taylor SM, Brown E Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br J Pharmacol 133 687-94,2001... 

Slattery C, Campbell E, McMorrowT, and Ryan MP. Cyclosporine A-induced renal fibrosis a role for epithelial-mesenchymal transition. Am J Pathol 167 395-407, 2005. 

Other mechanisms and mediators have been implicated in the genesis and prevention of chronic CSA nephrotoxicity. Reactive oxygen species, besides their functional effects on renal function, are also mediators of tissue injury favoring fibrosis. Use of the antioxidant vitamin E inhibited increases in TGF-beta and osteopontin mRNA and development of renal fibrosis in CSA-treated rats [184]. Mazzali et al showed that hyperuricemia exacerbates experimental chronic CSA nephrotoxicity, apparently due to activation of the RAS and inhibition of renal NO production [520]. The complement system was studied in a mouse model of chronic CSA nephrotoxicify, and the authors found an increased expression of C3, C4d and membrane... 

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