Paromomycin sulfate

Wienen, F., and Holzgrabe, U. (2002). Characterization of paromomycin sulfate by capillary electrophoresis with UV detection after pre-capillary derivatization. Chromatographia 55,... 

Paromomycin sulfate has been recommended for other parasitic infections — Dientamoeba fragilis (25 to 30 mg/kg/day in 3 doses for 7 days) Diphyllobothrium latum, Taenia saginata, Taenia solium, Dipylidium caninum adults 1 g every 15 minutes P.968... 

Metronidazole is the most effective agent available for the treatment of individuals with all forms of amebiasis, with perhaps the exception of the person who is asymptomatic but continues to excrete cysts. That situation calls for an effective intraluminal amebicide, such as dUoxanide furoate, paromomycin sulfate, or diiodohy-droxyquin. Metronidazole is active against intestinal and extraintestinal cysts and trophozoites. 

Aminoglycosides amikacin sulfate gentamicin sulfate netilmicin sulfate paromomycin sulfate streptomycin sulfate tobramycin sulfate... 

Paromomycin sulfate is an aminoglycoside antibiotic that until recently was used in parasitology only for oral therapy of intestinal parasitic infections (see previous text). It has recently been developed for the treatment of visceral leishmaniasis. A phase 3 trial in India showed excellent efficacy for this disease, with a daily intramuscular dosage of 11 mg/kg for 21 days yielding a 95% cure rate, and noninferiority compared with amphotericin. The drug was registered for the treatment of visceral leishmaniasis in India in 2006. In initial studies, paromomycin was well tolerated, with common mild injection pain, uncommon ototoxicity and reversible liver enzyme elevations, and no nephrotoxicity. Paromomycin is much less expensive than liposomal amphotericin or miltefosine, the other promising new therapies for visceral leishmaniasis. 

Paromomycin Sulfate, USP. The isolation of paromomycin (Humatin) was reported in I9S6 from a fermentation with a Streptomyces sp. (PD 04998), a strain said to resemble 5. rimostis very closely. The parent organism had been obtained from soil samples collected in Colombia. Paromomycin. however, more closely re.sembles neomycin and streptomycin in antibiotic activity than it dtx s oxytetracycline, die antibiotic obtained from S. rintosus. 

Paromomycin sulfate is a basic oligosaccharide-type antibiotic with imique action against Entamoeba and [ErichomonasIt has recently been reported to be highly effective against the human tapeworms Taenia saglnata,... 

Paromomycin sulfate amminosidin, 0-2,6-diamino-2,6-dideoxy-P-L-idopyranosyl-(1 3)-... 

Lincomycin hydrochloride monohydrate Neomycin palmitate Paromomycin sulfate Potassium penicillin O Potassium phenethicillin Rolitetracycline Sodium cephalothin Sodium cloxacillin monohydrate Sodium colistimethate Sodium dicloxacillin monohydrate Sodium methicillin monohydrate Sodium nafcillin monohydrate Sodium oxacillin monohydrate Spectinomycin dihydrochloride pentahydrate Vancomycin sulfate Viomycin sulfate... 

The antibiotic paromomycin (sulfate) cured 12 of 13 patients infected with the cestode Hymenolepis nana.i 9 Cephamycin C (A-11884), an antibiotic isolated from Streptomyces limanii is active against Aspicularis tetraptera, Syphacia oBvelata and Ascaris lumbricoides.iso... 

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