Squamous oral cavity

The mouth is the region from the lips to the pharynx. The first step in the digestive process is chewing, or mastication, which is an initial mechanical breakdown of the food that facilitates its movement to the stomach. The mouth is lined with stratified squamous epithelium that provides extra protection from injury by coarse food materials. Three pairs of salivary glands secrete saliva into the oral cavity ... 

De Stefani, A. et al., Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx, Cancer, 95, 90, 2002. 

Fillies T, Werkmeister R, Packeisen J, Brandt B, Morin P, Weingart D, Joos U, Buerger H (2006) Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity. BMC Cancer 6 10... 

Piffko, J., Bankfalvi, A., Ofner, D., Joos, U., Bocker, W., and Schmid, K. W. 1995. Immunohistochemical detection ofp53 protein in archival tissues from squamous cell carcinomas of the oral cavity using wet autoclave antigen retrieval. J. Pathol. 776 69-75. 

The oral mucosa provides a protective covering for underlying tissues while acting as a barrier to the entry of microorganisms and toxins. Histologically, the stratified squamous epithelium lining the oral cavity exhibits a diverse structure as well as important inter-species differences. This... 

Gustavsson P, Jakobsson R, Johansson H, et al. 1998. Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus A case-control study in Sweden. Occup Environ Med 55 393-400. 

Protective-, this is found in the oral cavity, pharynx, esophagus and anal canal. The surface epithelium is stratified squamous and may be keratinized (see Section 1.3.1). 

In common with all epithelial interfaces (see Section 1.3.2), the epithelium of the oral cavity is supported by a basement membrane, which separates the epithelium from the underlying connective tissue layer (the lamina propria) (Figure 7.1). Oral epithelium is broadly similar to stratified squamous epithelia found elsewhere in the body, for example the skin (see Section 8.2.1), in that cells are produced by mitosis in the basal layer of the epithelium and these proliferating cells push existing cells towards the surface. The phases of this dynamic process are represented in four morphological layers ... 

Oral mucosae are composed of multiple layers of cells, which show various patterns of differentiation dependent on the functions of different regions in the oral cavity. The oral mucosa is covered by a stratified, squamous epithelium, and three different types of mucosa can be distinguished the masticatory, the lining, and the specialized mucosa. Blood supply to the oral cavity tissues is delivered via the external carotid artery, which branches to the maxiliary lingual and facial artery. There are no mucus-secreting goblet cells in the oral mucosa, but mucins are found in human saliva. These mucins are water-soluble and form a gel of 10-200 pm thickness. Saliva, mainly composed of water (99%), is continuously secreted in the oral cavity and exists as a film with a thickness of 0.07-0.1 mm. ... 

Figure 12 Composite dose-response data for rat and mouse drinking water bioassays. Vinyl acetate induced squamous cell carcinoma of the oral cavity, esophagus, and forestomach. The tumor incidence was greatest for the oral cavity. These data, which include male and female rats and mice, illustrate the sharp break in the dose-response curve with clear evidence for a practical threshold. Data are from Bogdanffy et al. (65), Maltoni et al. (46), and JBRC (45).

Digestive System Oral cavity, Squamous cell papillomas and Yes" Betton et al. (2001), Frantz et rd. 

Myhre-Jensen O and Astrup T (1971). Fibrinolytic activity of squamous epithelium of the oral cavity and oesophagus of the rat, guinea-pig and rabbit. Arch Oral Biol, 16, 1077. 

Coletta RD, Cotrim P, Almeida OP, et al. Basaloid squamous carcinoma of oral cavity a histologic and immunohistochemical study. Oral Oncol. 2002 38(7) 723-729. 

Barnes EL, Hunt JL. Squamous cell carcinoma of the oral cavity and oropharynx A review of current data. Sel Readings Oral Maxillofac Surg. 2003 3(ll) l-40. 

Medina JE, Dichtel W, Luna MA. Verrucous-squamous carcinomas of the oral cavity. A clinicopathologic study of 104 cases. Arch Otolaryngol. 1984 10(7) 437-440. 

Detection of squamous cell carcinoma of the oral cavity by imaging... 

Other abnormal expressions of nuclear RA receptors have been observed. Normal epithelial cells (keratinocytes) of the oral cavity typically express RARy transcripts. Most squamous cell carcinomas (SCC) derived from this... 

The squamous cell carcinoma of the oral cavity arises due to viral (HPV, EBV), bacterial Porphyromonas gingivalis) and chemical (tobacco smoke ethanol) etiological factors reviewed in [73]. The ras genes are prominent inducers of the PI3K/Akt, Mek/MAPK oncogenic pathways in head neck (intraoral) squamous cell carcinomas, and the involvement of microRNAs is recognized, but not as well discerned, as in the adenocarcinomas [1315]. 

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