Somatrem

Uses Chronic asthma Actions Topical steroid Dose Two inhalations tid-qid or 4 inhal bid Caution [C, ] Contra Component aU gy Disp Met-dose inhaler SE Cough, oral candidiasis Interactions T Risk of GI bleed W/ ASA, NSAIDs T effects W/ sakneterol, troleandomycin -1- effects W/barbiturates, hydantoins, pheny-toin, rifampin T effects OF diuretics, insulin, oral hypoglycemics, K supl, salicylates, somatrem, live virus vaccines EMS May affect glucose(hyperglycemia) monitor ECG for hypokalemia (flattened T waves) concurrent ASA/NSAID use may t risk of GI bleeding OD Acute OD unlikely to cause life-threatening Sxs, chronic OD may lead to S/Sxs of muscle weakness, and osteoporosis symptomatic and supportive... 

Dosage form Protropin is supplied as a sterile, lyophilized powder for reconstitution with bacteriostatic water for injection. Each vial contains somatrem 5 mg or 10 mg. 

Pharmacokinetics The same area under the curve (AUC) and disappearance rates are observed following injection of pituitary-derived hGH or Somatrem. 

F. Role in therapy Micromedex notes that like somatropin (rDNA origin), somatrem is effective in the treatment of children with documented defidenq of growth hormone its effectiveness in constitutional short stature remains to be determined. Somatrem can be considered to be equal to somatropin in efficaq , but because of the increased incidence of immunogenic effects resulting in neutralizing antigrowth hormone antibodies seen with somatrem, it will likely take a secondary role to recombinant somatropin products in therapy. 

Somatrem-recombinant human pituitary growth hormone produced in E. coli... 

Somatrem [FDA USAN INN BAN JAN] Somatropin (human), A-L-methionyl- [CAS] Growth hormone, A-L-methionyl- [CAS] Growth hormone (human), A-L-methionyl-[CAS]... 

Leukemia has been reported in a small number of pediatric patients who have been treated with growth hormone, including growth hormone of pituitary origin as well as recombinant DNA origin (somatrem and somatropin). The relationship, if any, between leukemia and growth hormone therapy is unknown... 

Protropin-N utropin Somatrem-somatropin Growth deficiencies 224... 

Protropin Somatrem Growth hormone deficiency Genentech 2005... 

Growth hormone (somatrem, somatropin) and corticotrophin use may be combined with that of anabolic steroids. Chorionic gonadotrophin may be taken to stimulate testosterone production (and prevent testicular atrophy). Similarly, tamoxifen (antioestrogen) may be used to attenuate some of the effects of anabolic steroids. 

Somatropin and Somatrem) Humatrope (Eli Lilly) and in children GH deficiency in adults Growth retardation in chronic renal disease... 

GH has been recognixed as an effective replacement therapy for GH-deficient children. The supply of GH. however, was very limited because its source was the pituitary glands of human cadavers, and several reports of deaths in children with Creut/fcldt-Jakob disease (caused by viral contamination of GH) baited the di.stribution of GH in 1977. Both of these problems were. solved with the application of rDNA technology in the commercial production of somatrem and snmatmpin. 

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