Immunogens effectiveness

F. Role in therapy Micromedex notes that like somatropin (rDNA origin), somatrem is effective in the treatment of children with documented defidenq of growth hormone its effectiveness in constitutional short stature remains to be determined. Somatrem can be considered to be equal to somatropin in efficaq , but because of the increased incidence of immunogenic effects resulting in neutralizing antigrowth hormone antibodies seen with somatrem, it will likely take a secondary role to recombinant somatropin products in therapy. 

The major drawback for plant-derived complex biopharmaceuticals is that the plant-specific xylosyl and fucosyl residues are attached to the core structure of N-gly-cans. Although Ghargelegue et al. [62] observed no immunogenic effects of a plant-derived murine monoclonal antibody in an animal study based on a mouse model, both residues are described in the Htera-ture as structures with high immunogenic potential [8, 9]. 

Rihova, B., Ulbrich, K., Strohalm, J., Vetvicka, V., Bilej, M., Duncan, R. and Kopecek, J. (1989) Biocompatibility of N-(2-hydroxypropyl)-methacrylamide copolymers containing adiiamycin. Immunogenicity, effect on hematopoietic stem cells in bone marrow in vivo and effect on mouse splenocytes and human peripheral blood lymphocytes in vitro. Biomaterials 10 335-342. 

The Mn(ii)-based SOD mimics have numerous potential advantages over the SOD enzymes as potential therapeutic agents, including membrane permeability, selective reactivity for superoxide, immunogenicity effects, stability, and cost. Table 1 compares characteristics of the Mn(ii)-based SOD mimics with R = H versus those of bovine erythrocyte Cu,Zn SOD. 

Table 2. Some immunogens effective after non-covalent association with carriers ... 

These results strongly suggest that the immunogenic effect of acetylsalicylic acid preparations as observed in experimental animals is due to acetylsalicylic anhydride and/or acetylsalicylsalicylic acid present as impurities in the preparations and not to the acetylsalicylic acid itself. By extrapolation of these findings to clinical acetylsalicylic acid allergy, it may appear that the impurities rather than the drug substance itself are responsible for the appearance of anti-salicyloyl antibodies in patients treated with acetylsalicylic acid. 

Gavasso S, Gjtatsen B, Anderssen E, Myhr K, Vedeler C. Immunogenic effects of recombinant interferon-beta therapy dismpt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis. Mult Scler. 2012 18 1116-24. 

KUCHAREwicz-KRUKOwsKA, A. SLOPEK, s. (1987) Immunogenic effect of bacteriophage in patients subjected to phage therapy. Archivum Immunologiae et Thera-piae Experimentalis, 35,553. 

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