Growth hormone deficiency

Insulin Prolactin Growth hormone 11p15 6p23-q12 17q21-qter Growth hormone deficiency... 

Identify the clinical features of children and adults with growth hormone deficiency and select appropriate pharmacotherapy for these patients. 

Recombinant growth hormone therapy is the main pharmacologic treatment for growth hormone deficiency in both children and adults. 

Although comparative trials have not been conducted, recombinant growth hormone products appear to have similar efficacy for treating growth hormone deficiency. 

Damage and destruction of the pituitary gland may result in secondary hypothyroidism, hypogonadism, adrenal insufficiency, growth hormone deficiency, hypoprolactinemia, or... 

Growth Hormone Deficiency in Children Patient Care and Monitoring... 

Genotropin Somatropin Pharmacia Upjohn Short stature in children due to growth hormone deficiency... 

Humatrope Somatropin Eli Lilly Human growth hormone deficiency in children... 

Jorgensen, J. and Christiansen, J. (eds). 2005. Growth Hormone Deficiency in Adults. S. Karger AG. Juul, A. 2000. Growth Hormone in Adults. Cambridge University Press. 

E6. Eden, S., Wiklund, O., Oscarsson, J., Rosen, T., and Bengtsson, B. A., Growth hormone treatment of growth hormone deficient adults results in a marked increase in lipoprotein(a) and HDL-cholesterol concentration. Atheroscler. Thromb. 13, 296-301 (1993). 

Various studies have confirmed that rhGH promotes increased linear growth rates in children suffering from pituitary dwarfism (classical growth hormone deficiency). Dosages are generally... 

Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Shalet SM, Vance ML et al. Evaluation and treatment of adult growth hormone deficiency an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2006 91 1621-34. 

Saenger P. Growth hormone in growth hormone deficiency. BMJ 2002 13(325) 59-60. 

Growth hormone deficiency in children must be determined by measuring hormone levels after giving an agent that stimulates release because... 

GH synthesis and secretion does not disappear when linear growth is complete. In fact isolation of hGH from cadaver pituitary glands would not have been possible if it did. Physicians caring for adult patients with pituitary disease began to realize that even with optimum replacement of other hormones, patients who acquired GH deficiency in adulthood complained bitterly about diminished quality of life. Studies from Europe also documented increased cardiovascular morbidity and mortality in these patients [13], Because it was no longer necessary to conserve scarce supplies of hGH for use in children, physicians were able to study GH effects in adults with growth hormone deficiency. These studies have shown that GH improves body composition (decreases fat mass and increases lean body mass) and decreases risk factors for cardiovascular disease [14]. 

Kaplan, S.L., L.E. Underwood, G.P August, J.J. Bell, S.L. Blethen, R.M. Blizzard, D.R. Brown, T.P Foley, R.L. Hintz, N.J. Hopwood, et al.. Clinical studies with recombinant-DNA-derived methionyl human growth hormone in growth hormone deficient children. Lancet, 1986.1(8483) 697-700. 

Bengtsson, B.A., G. Johannsson, S.M. Shalet, H. Simpson, and RH. Sonken, Treatment of growth hormone deficiency in adults. J Clin Endocrinol Metab, 2000. 85(3) 933 2. 

E. Therapeutic response Protropin has been found to be effective in achieving growth rate increases in children with growth hormone deficiency. 

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