Sodium m-bisulfite

Cellulose Acetate Butyrate (CAB) 3-8 Low Density Polyethylene (LDPE) 1-9 Sodium m-Bisulfite ... 

Low Density Polyethylene (LDPE) 7-9 see Sodium m-Bisulfite Nylon 66 (PA 66) 5-9... 

Silicic Acid 10193-36-9 Sodium m-Bisulfite 7681-57-4 Sulfurous Acid 7782-99-2... 

Sodium Hypochlorite Sodium Hypophosphite Sodium m-Bisulfite Sodium Pyrosulfite Nitric Acid Zinc Bromide Colloidal Sulfur Sulfur Ferric Chloride Ferric Choride Iron (III) Chloride Iron Perchloride Dipentene p-Menthadiene... 

Regulatory FDA 21CFR 137.105, 172.802 Acetone sodium bisulfite CAS 540-92-1 EINECS/ELINCS 208-761-2 Synonyms 2-Hydroxy-2-propane sulfonic acid sodium salt acetone sulfite Sodium acetone bisulfate Sodium acetone bisulfite Empirical CsH7Na04S Formula (CH3)2C(0H)S03Na Properties Cryst, si. SO2 odor, fatty feel sol. in water si. sol. in alcohol m.w. 162.15 Toxicology LD50 (IP, mouse) > 1 g/kg TSCA listed... 

Acetoxy-1,3-butadiene (1,3-butadienyl acetate) cis-trans mixture [1515-76-0] M 112.1, b 42-43 /16mm, 51-52 /20mm, 60-61 /40mm, d 4 0.9466, n g 1.4622. The commercial sample is stabilised with 0.1% of p-/er/-butylcatechol. If the material contains crotonaldehyde (by IR, used in its synthesis) it should be dissolved in Et20, shaken with 40% aqueous sodium bisulfite, then 5% aqueous... 

The enol lactone (12.7 g) is added to 157 ml of 0.5 M perbenzoic acid in benzene and allowed to stand at 25° for 140 hr. The solution is cooled to 15° and 15% sodium bisulfite solution is added to neutralize the excess peracid. The organic layer is separated and washed with saturated sodium bicarbonate solution and water. The benzene solution is dried over anhydrous sodium sulfate, filtered and concentrated to 30 ml. The product is crystallized by adding 80 ml of petroleum ether, filtered and washed with petroleum ether to yield 12.8 g (98%) of 3a,20,23-trihydroxy-16a-methyl-17(20)-oxido-ll-oxo-21-norchol-22-enoic acid-24(20)-lactone 3,23-diacetate mp 225-227°. 

The reaction product, which is a dark reddish-brown liquid, is poured or siphoned (Note 5) into 1.5 1. of water to which 50 cc. of a saturated solution of sodium bisulfite has been added (Note 6). The mixture is distilled with steam (Org. Syn. 2, 80) and the first portion of the distillate is collected separately to remove a small amount of unchanged nitrobenzene. It is necessary to collect about 12 1. of distillate in order to obtain all of the m-bromonitrobenzene. The yellow crystalline solid is filtered with suction and pressed well on the funnel to remove water and traces of nitrobenzene. The yield of crude product varies from 270-340 g. (60-75 Per cent °f the theoretical amount). It melts at 51.5-520 and boils at 117-118 79 mm. This product is satisfactory for most purposes. If a purer material is desired, the crude /w-bromonitrobenzene may be distilled under reduced pressure. The recovery on purification is about 85 per cent. Briihl recorded the b.p. as 1380/18 mm. and the m.p. as 56° for pure wz-bromonitrobenzene.1... 

Prepare bisulfite modification solution consisting of 3 M concentration of a diamine (i.e., ethylenediamine), 1M sodium bisulfite, pH 6. The use of the dihydrochloride form of the diamine avoids having to adjust the pH down from the severe alkaline pH of the free-base form. Note The optimum pH for transaminating biotin-hydrazide to cytosine residues using bisulfite is 4.5 (see Section 2.3, this chapter). 

A mixture of 10 g. of D-galactose, 10 ml. of ethyl acetoaeetate, 10 ml. of ethanol, and 5 g. of zinc chloride is heated on a steam bath during 75 minutes. The mixture is cooled, 45 ml. of water is added, and the solution is extracted with two 30-ml. portions of benzene. The aqueous layer is then extracted with nine 15-ml. portions of ethyl acetate. The united extracts are washed successively with an aqueous solution of sodium bisulfite and with an aqueous solution of sodium bicarbonate, dried with anhydrous sodium sulfate, filtered, and the filtrate evaporated to dryness, affording 4.5 g. of a sirup. This is saponified with 12.5 ml. of 10% sodium hydroxide solution, and then acidified (to Congo Red) with phosphoric acid. The aqueous solution is extracted with successive 30-ml. portions of ethyl acetate, and these are dried with anhydrous sodium sulfate, and individually evaporated to dryness. Extracts after the fourth yield a solid product m. p., 130°. Recrystallized from petroleum ether plus acetic acid, the compound has m. p. 132-134° yield, variable, ca. 2%.54... 

A mixture of 2.65 g. of freshly distilled 2,3-O-isopropylidene-D-glycerose, 1.5 ml. of ethyl acetoacetate, 0.7 g. of zinc chloride, 20 ml. of N sulfuric acid, and 20 ml. of 96% ethyl alcohol is kept at room temperature for twenty-four hours. After addition of 3 g. of crystalline sodium acetate and keeping for a further 48 hours at room temperature, the mixture is heated for 15 minutes at 90°. It is then repeatedly extracted with ether, and the united extracts are successively washed with water, an aqueous solution of sodium bisulfite, and a small quantity of aqueous sodium hydroxide solution. The ether layer is dried with anhydrous sodium sulfate and the solvent is evaporated, yielding an oil which is saponified with aqueous sodium hydroxide solution (4 ml. of 10%) by heating on a steam bath for one hour. The aqueous solution is extracted with ether, acidified (to Congo Red) with phosphoric acid, and then repeatedly extracted with ether the united extracts are dried with anhydrous sodium sulfate and the solvent is evaporated, giving a residue which crystallizes from water yield, 0.2 g. of the product (X) m. p., 153-155°. 

A mixture of 4.5 g. of 1-hydroxy-2-propanone, 80 ml. of ethyl acetoacetate, 60 ml of 96% ethyl alcohol, and 4 g. of anhydrous zinc chloride is heated under reflux on a steam bath for half an hour. After cooling, it is poured into water and extracted with benzene. The extract is washed successively with a bisulfite solution (twice), dilute aqueous sodium hydroxide, and dilute hydrochloric acid, and is dried over anhydrous sodium sulfate. The benzene is evaporated, giving 4 g. of an almost colorless oil which is saponified by heating with 5 g. of sodium hydroxide in 20 ml. of 96% alcohol for half an hour on a steam bath. Part of the alcohol is evaporated, water is added, and the solution is extracted twice with ether. The aqueous layer is acidified (to Congo Red) with hydrochloric acid (1 1). The resulting solid is removed by filtration and recrystallized from 180 ml. of water yield, about 3 g. It may be purified by steam distillation, affording colorless crystals m. p., 120-122°. 

Addition products have been obtained from aminochrome derivatives such as the semicarbazone, with sodium bisulfite. Recently Correia Alves reported the preparation of a compound described as adrenochrome semicarbazone sodium sulfonate (m.p. >300°) by treating a solution of adrenochrome monosemicarbazone (90) in sodium carbonate solution with sulfur dioxide at 40° for several days192 this compound was apparently different from the substance (m.p. 227-228°) obtained in a somewhat similar manner by Iwao193-194 and may be comparable to the compound (83) (m.p. > 300°) previously described in a Belgian patent179 (see Section IV,F). Iwao established the structure of his compound as the sodium salt of epinochrome-3-sulfonic acid monosemicarbazone (93).193... 

A sensitive spectrophotometric method based on the strong absorption of the aminochrome-sodium bisulfite addition products (see Section IV, F) at ca. 350 m/x. has been described recently by van Espen128and Oesterling and Tse 277-278 for determining total catecholamines. While not as sensitive as the fluorimetric procedures, this method is considerably more sensitive than the older colorimetric methods based on the visible absorption peak of the aminochromes. Also, it does not have many of the disadvantages (e.g. costly equipment and unstable blanks) often associated with fluorimetric techniques. The basic procedure can be satisfactorily applied to the differential determination of mixtures of adrenaline, noradrenaline, dopamine, metanephrine, and normetanephrine.178... 

The testosterone ester derivative (10 mmol) is dissolved in ca. 100 ml of a solution of hydrazoic acid in chloroform (0.15 M)138 and treated with stirring with a solution of 20 ml of f-butyl alcohol and N-chlorosuccinimide (2 g, 15 mmol). The reaction mixture is stirred for 8-10 hr and then added with stirring to a saturated solution of sodium bisulfite. The mixture is diluted with 200 ml of chloroform and washed with water. The chloroform layer is further washed with dilute sodium bicarbonate solution and water, dried (Na2S04) and the solvent removed in vacuo. The residual /-butyl alcohol is removed by repeatedly adding methanol to the product and concentrating to dryness in vacuo. The residue is triturated four times with Skellysolve F to separate the two isomeric adducts, (103) and (104). 

The acid can be prepared from picryl chloride according to the method described by Golumbic, Fruton, and Bergmann,6 but the following modifications are recommended sodium metabisulfite should be used in place of sodium bisulfite the crude sodium salt is not recrystallized but is converted directly to the acid by the addition of hydrochloric acid to its acetone solution the product is recrystallized by dissolving it in a minimum amount of hot acetone, adding chloroform until crystallization starts, and cool- ing to about 0°. Two recrystallizations yield a product with m.p. 194-196°. 

Add sodium bisulfite to obtain a final concentration of 1 M in the reaction medium. 

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