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Testosterone esters

The testosterone ester derivative (10 mmol) is dissolved in ca. 100 ml of a solution of hydrazoic acid in chloroform (0.15 and treated with stirring... [Pg.35]

Bromine azide addition to testosterone esters is achieved by the same procedure with the use of //-bromosuccinimide. [Pg.35]

Shackleton CHL, Chuang H, Kim J, de la Torre X, Segura J. 1997. Electrospray mass spectrometry of testosterone esters potential for use in doping control. Steroids 62 ... [Pg.191]

In applied medicine, testosterone esters (propionate, cypionate, and enantate) and a synthetic analog, methyltestosterone, are widely used. In many tissues, testosterone s androgenic... [Pg.381]

IM Testosterone esters in oil injected IM are absorbed slowly from the lipid phase thus, testosterone cypionate and enanthate can be given at intervals of 2 to 4 weeks. [Pg.235]

Sleep apnea The treatment of hypogonadal men with testosterone esters may potentiate sleep apnea in some patients, especially those with risk factors such as obesity or chronic lung diseases. [Pg.237]

J. Vindevogel, P. Sandra, Resolution optimization in micellar electrokinetic chromatography use of Plackett-Burman statistical design for the analysis of testosterone esters,, 4na/. C/iem., 63 (1991) 1530-1536. [Pg.146]

The testosterone ester derivative (10 mmol) is dissolved in ca. 100 ml of a solution of hydrazoic acid in chloroform (0.15 M)138 and treated with stirring with a solution of 20 ml of f-butyl alcohol and N-chlorosuccinimide (2 g, 15 mmol). The reaction mixture is stirred for 8-10 hr and then added with stirring to a saturated solution of sodium bisulfite. The mixture is diluted with 200 ml of chloroform and washed with water. The chloroform layer is further washed with dilute sodium bicarbonate solution and water, dried (Na2S04) and the solvent removed in vacuo. The residual /-butyl alcohol is removed by repeatedly adding methanol to the product and concentrating to dryness in vacuo. The residue is triturated four times with Skellysolve F to separate the two isomeric adducts, (103) and (104). [Pg.265]

Hirsutism is common in patients taking androgens, and is often irreversible (62,63). In contrast, in women, loss of scalp hair can occur (64). Of 81 female-to-male transsexual subjects, mean age 37 years (range 21-61), treated with testosterone esters (n = 61 250 mg intramuscularly every 2 weeks) or testosterone undecanoate (n = 20 160-240 mg/day orally), 31 developed male-pattern baldness thinning of the hair was related to the duration of androgen administration and was present in about half of the transsexuals after 13 years (65). [Pg.141]

A 20-year-old man with idiopathic hypogonadotrophic hypogonadism receiving a testosterone ester in a dose of 250 mg intramuscularly every 2 weeks developed priapism (68). [Pg.142]

Testosterone is available as oral testosterone undecano-ate, buccal testosterone, intramuscular testosterone esters, testosterone implants, and testosterone transdermal patches and gel. Proponents of transdermal testosterone products, such as gels and scrotal or non-scrotal dermal patches, claim that they have a good safety profile (101). Transdermal testosterone replacement certainly improves bone mass and lean body mass, reduces fat mass, and improves mood and sexual function. There are said to be no harmful effects on the prostate and lipids. Acne, polycythemia, and gynecomastia are stated to be less common with this form of therapy than with the intramuscular esters. To date these claims must be regarded with some reservations it is not at all clear that in equieffective doses the local or topical forms of administration dissociate wanted and unwanted effects. [Pg.145]

Mackey MA, Conway AJ, Handelsman DJ. Tolerability of intramuscular injections of testosterone ester in oil vehicle. Hum Reprod 1995 10(4) 862-5. [Pg.149]

Whitsel EA, Boyko EJ, Matsumoto AM, Anawalt BD, Siscovick DS. Intramuscular testosterone esters and plasma hpids in hypogonadal men a meta-analysis. Am J Med 2001 lll(4) 261-9. [Pg.149]

An improvement in the prediction of androstanolone, nandrolone, and testosterone ester solubilities in organic solvents was possible by includihg in the calculations (James et al., 1976). [Pg.14]

Active-Life Various due to 3 testosterone esters (About 21 days total)... [Pg.37]

An interesting (underground) manufacturer called GAC (Generic Agriculture and Chemical) has created a multiple testosterone ester product aptly called Godzillabol. The product may be available in Mexico and is provided in a 6 milliliter vial. Some would assume this is nothing more than another Sustanon-250 knock-off, but they could not be more wrong. [Pg.49]

Noguchi, T., W.N. Charman, and V.J. Stella. 1985. The effect of drug lipophilicity and lipid vehicles on the lymphatic absorption of various testosterone esters. Int J Pharm 24 173. [Pg.130]

Testosterone contains 19 carbon atoms in a four-ring structure, with each numbered from one to 19. Modifications in the carbon atoms creates the hundreds of synthetic AASs that exist today. For example, many common synthetic forms of testosterone have alterations on their seventeenth carbon. AASs created in pill form have an added alkyl group, which is a chain of carbon and hydrogen atoms. These 17-alkylated AAS compounds are more toxic to the liver and more likely to cause cholesterol abnormalities. Common 17-aldylated AASs include Dianabol, Android, and Winstrol. When the addition to the seventeenth carbon is an ester, which is an acidic chain of carbon and hydrogen, the synthetic form is an injectable form that is less toxic on the liver and cholesterol levels. Depo-Testosterone is an example of the injectable testosterone ester. AAS abusers also use veterinary products, such as Finajet and Equipoise, that have been devised for animal usage. [Pg.453]

CD curves for testosterone phenylpropionate in four different solvents are shown in Figure 6. Curves for the other compounds, testosterone, methyltestosterone, different testosterone esters, nandrolone phenylpropionate, norethisterone, and d-norgestrel, are essentially coincident with those in Fig. 6. The figure also demonstrates well how an increase in solvent polarity leads to a... [Pg.300]


See other pages where Testosterone esters is mentioned: [Pg.445]    [Pg.35]    [Pg.452]    [Pg.389]    [Pg.359]    [Pg.542]    [Pg.181]    [Pg.382]    [Pg.382]    [Pg.383]    [Pg.772]    [Pg.234]    [Pg.265]    [Pg.1551]    [Pg.145]    [Pg.37]    [Pg.49]    [Pg.49]    [Pg.51]    [Pg.51]    [Pg.53]    [Pg.55]    [Pg.55]    [Pg.55]    [Pg.57]    [Pg.59]    [Pg.63]    [Pg.74]    [Pg.366]    [Pg.630]   
See also in sourсe #XX -- [ Pg.252 ]

See also in sourсe #XX -- [ Pg.353 ]

See also in sourсe #XX -- [ Pg.1274 , Pg.1277 ]

See also in sourсe #XX -- [ Pg.103 , Pg.412 , Pg.413 , Pg.416 ]




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