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Silicon microparticles

SLE. An early hypothesis is that the prosthesis or injected silicone plays an adjuvant role by enhancing the immune response through increased macrophage and T-cell helper function. There is currently controversy as to whether silicone, as a foreign body, induces a nonspecific inflammation reaction, a specific cell-mediafed immunological reaction, or no reaction at all. However, there is strong support to indicate that silicone microparticles can act as haptens to produce a delayed hypersensitivity reaction in a genetically susceptible population of people. [Pg.169]

With the aim of developing a drug delivery vehicle, hydrosilylated and thermally oxidized porous silicon microparticles were injected into the vitreous of rabbit eyes (Cheng et al. 2008). It was noted that the particles settled into the inferior vitreous cavity over a few days. Degradation of the hydrosilylated particles took considerable time (>4 months) in comparison to untreated particles which degraded within a period of 3 weeks. No adverse effects were observed in ocular tissues including the retina and the lens. Furthermore, normal ocular pressure was maintained. [Pg.5]

Kilpelainen M, Riikonen J, Vlasova MA, Huotari A, Lehto VP, Salonen J, Herzig KH, Jarvinen K (2009) In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles. J Control Release 137(2) 166-170... [Pg.11]

Salonen J, Laitinen L, Kaukonen AM, Tuura J, Bjorkqvist M, Heikkila T, Vaha-Heikkila K, Hirvonen J, Lehto VP (2005) Mesoporous silicon microparticles for oral drug delivery loading and release of five model drugs. J Control Release 108 362-374... [Pg.12]

Santos HA, Riikonen J, Salonen J, Makila E, Heikkila T, Laaksonen T, Peltonen L, Lehto V-P, Hirvonen J (2010) In vitro cytotoxicity of porous silicon microparticles effect of the particle concentration surface chemistry and size. Acta Biomater 6(7) 2721-2731... [Pg.12]

Laaksonen T, Santos H, Vihola H, Salonen J, Riikonen J, Heikkila T, Peltonen L, Kumar N, Murzin D, Lehto V, Hirvonen J (2007) Failure of MTT as a toxicity testing agent for mesoporous silicon microparticles. Chem Res Toxicol 20(12) 1913-1918 Low SP (2008) Development of porous silicon as a scaffold for the delivery of cells into ocular tissue. Flinders University, Department of Chemistry Low SP, Williams KA, Canham LT, Voelcker NH (2006) Evaluation of mammahan cell adhesion on surface modified porous silicon. Biomaterials 27 4538-4546 Masters J (2000) Animal cell culture a practical approach. OUP, Oxford... [Pg.33]

Crystalline silicon is a strong but brittle material. The introduction of porosity often lowers hardness, stiffiiess, and fracture strength (see handbook chapter Mechanical Properties of Porous Silicon ), and if the stmcture becomes too weak, it cannot often survive common material processing techniques without alteration. Examples include air drying (see handbook chapter Drying Techniques Applied to Porous Silicon ), reduction of particle size via communition (see handbook chapter Milling of Porous Silicon Microparticles ), and oxidation of layers (see handbook chapter Oxidation of Mesoporous Silicon ). The properties of electrochemically etched layers can depend not only on etch parameters but how the material was dried. The properties of microparticles can be sensitive to how they were milled. [Pg.39]

Landry MR (2005) Thermoporometry by differential scanning calorimetry experimental considerations and applications. Thermochim Acta 433(l-2) 27-50. doi 10.1016/j.tca.2005.02.015 Lehto VP, Vaha-Heikkila K, Paski J, Salonen J (2005) Use of thermoanalytical methods in quantification of drug load in mesoporous silicon microparticles. J Therm Anal Calorim 80(2) 393-397... [Pg.47]

Salonen J, Paski J, Vaha-Heikkila K, Heikkila T, Bjorkqvist M, Lehto VP (2005b) Determination of drug load in porous silicon microparticles by calorimetry. Phys Status Solidi A-Appl Mater Sci 202(8) 1629-1633... [Pg.48]

Wang F, Hui H, Barnes TJ, Barnett C, Prestidge CA (2010) Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs. Mol Pharm 7(l) 227-236. doi 10.1021/mp900221e... [Pg.48]

Limnell T, Riikonen J, Salonen J, Kaukonen AM, Laitinen L, Hirvonen J, Lehto VP (2006) The effect of different surface treatment and pore size on the dissolution of ibuprofen from mesoporous silicon particles. Eur J Pharm Sci 28 S34-S34 Limnell T, Riikonen J, Salonen J, Kaukonen AM, Laitinen L, Hirvonen J, Lehto VP (2007) Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles. Int J Pharm 343 141-147... [Pg.86]

Wu EC, Andrew JS, Buyanin A, Kinsella JM, Sailor MJ (2011a) Suitability of porous silicon microparticles for the long-term delivery of redox-active therapeutics. Chem Commun 47 5699-5701... [Pg.90]

Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) delivery. Eur J Pharm Biopharm 77(l) 20-25. doi 10.1016/j.ejpb.2010.10.004... [Pg.119]

Bimbo LM, Sarparanta M, Santos HA, Airaksinen AJ, Makila E, Laaksonen T, Peltonen L, Lehto VP, Hirvonen J, Salonen J (2010) Biocompatibility of thermally hydrocarbontzed porous silicon nanoparticles and their Biodistribution in Rats. ACS Nano 4 3023 Bimbo LM, Makila E, Raula J, Laaksonen T, Laaksonen P, Strommer K, Kauppinen El, Salonen J, Linder MB, Hirvonen J, Santos HA (2011) Functional hydrophobin-coating of thermally hydrocarbonized porous silicon microparticles. Biomaterials 32 9089 Bimbo LM, Sarparanta M, Makila E, Laaksonen T, Laaksonen P, Salonen J, Linder MB, Hirvonen J, Airaksinen AJ, Santos HA (2012) Cellular interactions of surface modified nanoporous silicon particles. Nanoscale 4 3184... [Pg.209]

Gu L, Park J-H, Duong KH, Ruoslahti E, Sailor MJ (2010) Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads. Small 22 2546... [Pg.403]

Chiappini C, Tasciotti E, Fakhoury JR, Fine D, Pullen L, Wang YC, Fu L, Liu X, Ferrari M (2010) Tailored porous silicon microparticles fabrication and properties. Chem Phys Chem 11 (5) 1029-1035... [Pg.452]

High porosity silicon microparticles have potential in this regard for brown cosmetic facial products like foundation (Canham and Monga 2010). [Pg.548]

Won CW et al (2009) Porous silicon microparticles synthesis by solid flame technique. Microporous Mesoporous Mater 126 166-170... [Pg.621]

Ouyang H, DeLouise LA, Miller BL, Fauchet PM (2007) Label-free quanhtative detechon of protein using macroporous silicon photonic bandgap biosensors. Anal Chem 79(4) 1502-1506 Pastor E, Matveeva E, Valle-Gallego A, Goycoolea FM, Garcia-Fuentes M (2011) Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles. Colloids Surf B Biointerfaces 88(2) 601-609... [Pg.644]

Vale N, Makila E, Salonen J, Gomes P, Hirvonen J, Santos HA (2012) New times, new trends for ethionamide in vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles. Eur J Pharm Biopharm 81(2) 314-323... [Pg.645]

Highly targeted radiotherapy ( brachytherapy ) was the first clinical application of stain-etched silicon microparticles. We briefly review here the manufacture, testing, and clinical use of the P Si beta-emitting formulation for unresectable hepatocellular and pancreatic carcinoma. Clinical data Ifom a number of trials suggests that the technology offers patients with inoperable solid tumors an attractive alternative to external beam radiotherapy. [Pg.682]

See other pages where Silicon microparticles is mentioned: [Pg.560]    [Pg.382]    [Pg.682]    [Pg.4]    [Pg.4]    [Pg.13]    [Pg.83]    [Pg.84]    [Pg.88]    [Pg.100]    [Pg.102]    [Pg.119]    [Pg.121]    [Pg.206]    [Pg.213]    [Pg.268]    [Pg.303]    [Pg.343]    [Pg.428]    [Pg.453]    [Pg.473]    [Pg.483]    [Pg.548]    [Pg.645]   


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