Inflammation reaction

Hydrazine and hydroxyiamine give explosive or inflammable reactions with all chromates and dichromates. 

Another effector function/mode of action of mAbs is the so-called complement-dependent cytotoxicity or complement-mediated cell death . Activation of the complement system can lead to lysis of the antigen-presenting cell, or can induce inflammation reactions aimed at eliminating these cells efficiently. The successive steps of the complement activation can be summarized in a simplified way [9] ... 

Colchicine suppresses chemotactic properties in leukocytes and inhibits the inflammation reaction. Colchicine is easily absorbed from the intestinal tract and 40% is excreted in the urine within 40 hours. There is risk of accumulation on repeated administration. 

Glucocorticoid hormones promote gluconeogenesis and, in pharmacological doses, suppresses inflammation reactions, / -corticotropin is secreted from the anterior pituitary, and it stimulates the adrenal cortex to produce glucocorticoids and mineralocorticoids, which in turn act on a number of tissues. 

SLE. An early hypothesis is that the prosthesis or injected silicone plays an adjuvant role by enhancing the immune response through increased macrophage and T-cell helper function. There is currently controversy as to whether silicone, as a foreign body, induces a nonspecific inflammation reaction, a specific cell-mediafed immunological reaction, or no reaction at all. However, there is strong support to indicate that silicone microparticles can act as haptens to produce a delayed hypersensitivity reaction in a genetically susceptible population of people. 

Khang, G. Importance of inflammation reaction of scaffold for the application of regenerative medicine. Inflammation Regeneration 32(5), 178—196 (2012)... 

The results for treated blood vessels showed that after 4 weeks, the BASYC -prosthesis was wrapped up with connective tissue, pervaded with small vessels like vasa vasorum. The BASYC -interposition was completely incorporated in the body without any rejection reaction. Results from micronerve surgery (white rat sciatic nerve) showed similar results. From 4 to 26 weeks following the intervention, the bacterial cellulose tube was covered with connective tissue and contained small vessels. No inflammation reaction or capsulation of the implant was observed. The regeneration nerve was improved after 10 weeks, compared to an uncovered anastomosed nerve. 

The most obvious reaction of human skin towards an overexposure by UV light is the development of an erythema, which is an inflammation reaction of the skin well known as sunburn. Experiments with monochromatic radiation showed that the dose necessary for an erythemal response (1 minimal erythemal dose = 1 MED) depends strongly on the wavelength. The inverse of this dose as function of wavelength is called the erythemal action spectrum. It is used in a normalized form, such that the maximum value becomes unity. In 1987 McKinley and Diflfey reviewed a comprehensive amount of experimental data, and on this basis published an averaged erythemal action spectrum, which became a broadly accepted reference published by the CIE (International Comission on Illumination) and is shown in Fig. 2. ... 

Artificial implants, however, may cause many problems. Polyethylene, for example, will wear over time. Microscopic particles may break off and settle around the implant and surroimding tissue. The immune system of the body rejects the polyethylene debris and may react with a chronic local inflammation reaction, often causing osteolysis or "eating away of the bone. As the patient loses bone in his or her hip, the inq)lant may become loose and no longer function properly. The patient then must undergo major surgery once more to replace the inq)lant (17, 18). 

Biocompatibility experiments on PGA sewing thread indicate low inflammation reactions of the tissue. After two years, the implanted PGA specimen was completely degraded. Since these first experiments, numerous in-vivo investigations have been performed with PGA and no severe immune reactions have been recorded [990]. 

Currently, application opportunities for poly()5-hydroxybutyrates) (PHB) - a member of the polyhydroxy alkanoate group - are being explored. Only very mild body reactions were detected with PHB implants during an implantation time of 12 months, there were no indications of chronic inflammation reactions. Enzymes accelerate hydrolytic degradation of PHB [954]. 

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