Toxic agents testing

Table 1. Percutaneous toxicity of tested agents LD50 p.c. mg/kg [2] + standard deviation or (lower - upper confidence limit).

However, these methods do not allow to judge the full opportunity of alive creatures reaction after influence of the tested toxics agent, which presence was not supposed during examination. 

Evaluation of Results. At least two independent assays are carried out for each test article. The criterion for positive response is a reproducible and statistically significant result at any concentration for any strain. When positive results are obtained, the test is repeated, using the strain(s) and concentration range with which the initial positive results were observed. This range may be quite narrow for toxic agents. 

Identify the toxic agent and dose if possible Assess vital signs and level of consciousness Conduct laboratory tests... 

Dugway Proving Ground, located at Tooele, Utah, has been used for large area testing of Chemical Corps toxic agents and other chemical warfare materials Ref R. Clinton, ArmedForcesChemJ 5,... 

In order to better access, utilize, and interpret existing teratology and reproduction toxicity data, a comprehensive data extraction project funded by the EPA is in progress at ETIC. Specific experimental data are extracted from selected ETIC master file documents. These data are entered in approximately 60 data fields, which comprise a data extraction file record. These data fields include information such as the identification of the test agent, test animals, experimental protocol, and results. Data field identifiers are listed in Table 6. 

RH Rice University of California San Diego Establish a new short-term test for toxic agents using human epidermal cells... 

Any toxicological analysis involves two broad steps the first is extraction of the toxic agent from the biological matrix and the second is identification and quantitation of the isolated material. There are very few useful tests which can be applied directly to body fluids. Exceptions are urine screening tests for salicylate, ethclorvynol, and phenothiazine drugs. 

Perhaps the most renowned example is the extensively-used 2,4,5-T (2,4,5-trichlorophenoxyacetic acid), or rather the 2,3,7,8-tetrachlorodibenzo- -dioxin (TCDD) impurity which sometimes accompanies it. During massive use of the herbicide as a defoliant in the Vietnam war, TCDD was found almost by accident to be one of the most toxic synthetic substances ever tested. Soon, it was shown to be present in domestic 2,4,5-T as well as in the chemical warfare agents. Tests in laboratory animals demonstrated that some of the observed levels indeed were quite high enough to cause toxic effects (32). 

National Toxicology Program (NTP1408) Toxic agents. Includes compounds tested in traditional in vivo and in vitro toxicologic assays. 1408 Chemical descriptions are publicly available in PubChem. 20... 

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