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Targeted radiotherapy

Somatostatin Receptor Scintigraphy and Receptor-Targeted Radiotherapy... [Pg.1152]

Radiopharmaceuticals for therapeutic use must have a high target-to-background ratio. Targeted radiotherapy involves the use of molecular carrier such as a receptor-avid compound or an antibody to deliver a radionuclide to cell populations. [Pg.82]

Zalutsky, M. R., Pozzi, O., and Vaidyanatha, G,Targeted radiotherapy with alpha particle emitting radionuclides, paper presented at the International Symposium on Trends in Radiopharmaceuticals (ISTR-2005), Vienna, Austria, Nov. 14-18,2005. [Pg.95]

INTERNATIONAL ATOMIC ENERGY AGENCY, Labelling Techniques of Biomolecules for Targeted Radiotherapy, IAEA-TECDOC-1359, IAEA, Vienna (2003). [Pg.15]

While " T exhibits attractive nuclear properties for targeted radiotherapy (half-life 8.04 d 0.97 MeV (89%), 0.096 MeV (7%) and two gamma... [Pg.18]

EVALUATION OF PEPTIDES LABELLED WITH BETA EMITTING RADIONUCLIDES FOR RECEPTOR TARGETED RADIOTHERAPY OF MALIGNANT TUMOURS... [Pg.87]

While exhibits attractive nuclear properties for targeted radiotherapy (half-life 8.04 d Eoninx v 0-97 MeV (89%), 0.096 MeV (7%) and two gamma photons, 364 keV (81%) and 284 keV (6%)), wider application of 4 labelled somatostatin analogues in radiotherapy targeting somatostatin receptor subtype 2 is hampered by certain drawbacks. First, the 1 based analogues... [Pg.88]

COMPARATIVE EVALUATION OF LABELLED BIOMOLECULES FOR TARGETED RADIOTHERAPY... [Pg.169]

A number of radiolabelled somatostatin analogues have been reported in the literature, with potential application for targeted radiotherapy of somatostatin receptor positive tumours in tumour bearing rodent models and in humans [12.4-12.9]. [Pg.198]

A key factor in the apphcation of targeted radiotherapy is the need to maximize the tumour to normal ceU radiation dose ratio. In this study, a new series of peptides — including DOTA-Ahx-Oct (OCT), DOTA-Ahx-Ser-Val-Glu-Phe-Ala-Ahx-Oct (P3) and DOTA-Ahx-Gly-Ser-Val-Glu-Phe-Ahx-Oct (P4), where Ahx is epsilon amino hexyl — developed by Whetstone and Meares of the University of California at Davis, United States of America, were evaluated. These peptides include an additional 5 amino acid sequence, which is cleavable by cathepsin. This modification helps to improve the release and trapping of labelled catabolites within the cell [16.2]. These peptides were directly compared with radioiodinated glycated octreotate (Gluc-TOCA), which was shown to have the best internalization properties of the four peptides studied. A comparison of the binding capacity, internalization, exter-nalization and stability of each peptide was carried out under optimized conditions in order to determine their properties. [Pg.270]

BALTER, H., et al.. Radiolabelled DOTA-TATE Its evaluation for targeted radiotherapy, Alasbimn J. 8 (2005),... [Pg.292]

Targeted Radiotherapy with Antibodies Conjugated to Auger Electron Emitters... [Pg.528]

Zalutsky MR. Targeted radiotherapy of brain tumors. Br J Cancer 2004 90 1469-1473. [Pg.533]

See other pages where Targeted radiotherapy is mentioned: [Pg.1152]    [Pg.905]    [Pg.906]    [Pg.141]    [Pg.94]    [Pg.95]    [Pg.109]    [Pg.128]    [Pg.182]    [Pg.186]    [Pg.82]    [Pg.1152]    [Pg.127]    [Pg.1094]    [Pg.4]    [Pg.17]    [Pg.18]    [Pg.88]    [Pg.100]    [Pg.132]    [Pg.133]    [Pg.169]    [Pg.270]    [Pg.291]    [Pg.501]    [Pg.502]    [Pg.503]    [Pg.504]    [Pg.508]    [Pg.509]    [Pg.1844]   
See also in sourсe #XX -- [ Pg.1960 , Pg.2145 , Pg.2165 , Pg.2185 , Pg.2186 , Pg.2187 , Pg.2190 , Pg.2191 , Pg.2192 , Pg.2193 , Pg.2194 , Pg.2195 , Pg.2196 , Pg.2197 , Pg.2198 , Pg.2199 , Pg.2200 , Pg.2201 , Pg.2202 , Pg.2203 , Pg.2204 ]



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