Septra - Trimethoprim

Sensorcaine - Bupivacaine Sentapent - Ampicillin Sent) - Clobazam Separln - Tolnaftate Sepazon -Cioxazolam Septaione - Chlorhexidine Septicoi - Chloramphenicol Septiderm - 4-Chioro-3,B-xyienol Septidron - Pipemidic acid Septilisin - Cephalexin Septfvon-Lavril -Triclocarban Septosi) Sulfamerazine Septra - Sulfamethoxazole Septra - Trimethoprim Septural - Piromidlc acid Sepyron - Cyclandelate Serai - Secobarbital sodium Ser-Ap-Es - Hydrochlorothiazide Ser-Ap-Es - Hydralazine HCI Ser-Ap-Es - Reserpine Serax Bisacodyl Serax - Oxazepam... 

Many patents have been issued on the use of pyrogaUol derivatives as pharmaceuticals. PyrogaUol has been used extemaUy in the form of an ointment or a solution in the treatment of skin diseases, eg, psoriasis, ringworm, and lupus erythematosus. GaUamine triethiodide (16) is an important muscle relaxant in surgery it also is used in convulsive-shock therapy. Trimethoprim (2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is an antimicrobial and is a component of Bactrin and Septra. Trimetazidine (l(2,3,4-trimethoxybenzyl)piperazine (Vastarel, Yosimilon) is used as a coronary vasodilator. l,2,3,4-Tetrahydro-6-methoxy-l-(3,4,5-trimethoxyphenyl)-9JT-pyrido[3,4- ]indole hydrochloride is useful as a tranquilizer (52) (see Hypnotics, sedatives, ANTICONVULSANTS, AND ANXIOLYTICS). Substituted indanones made from pyrogaUol trimethyl ether depress the central nervous system (CNS) (53). Tyrosine-and glycine(2,3,4-trihydroxybenzyl)hydrazides are characterized by antidepressant and anti-Parkinson activity (54). 

Ms. Watson has diabetes and is taking tolbutamide (Orinase). Her primary care provider prescribes the combination drug sulfamethoxazole and trimethoprim (Septra) for a bladder infection. Discuss any instructions information you would give to Ms. Watson in the patient education session... 

Trimethoprim (Trimpex) interferes with the ability of bacteria to metabolize folinic acid, thereby exerting bacteriostatic activity. Trimethoprim is used for UTIs that are caused by susceptible microorganisms. Trimethoprim administration may result in rash, pruritus, epigastric distress, nausea, and vomiting. When trimethoprim is combined with sulfamethoxazole (Septra), the adverse effects associated with a sulfonamide may also occur. The adverse reactions seen with other anti-infectives, such as ampicillin, the sulfonamides, and cephalosporins, are given in their appropriate chapters. 

Septra DS Septra SS Antibiotic Tab Sulfamethoxazole 800 mg, trimethoprim 160 rrg Tab Sulfamethoxazole 400 mg, trimethoprim 80 mg Urinary tract infections 1 tab bid x 7-10 days Shigellosis 1 lab bid x 3-5 days Bronchitis 1 tab bid x 2 weeks Travelers diarrhea 1 tab bid x 5 days Rash common Stevens Johnson Syndrome (erythema multiforme) rarely UTI Prophylaxis 1 tabqhs... 

Septra IV Antibiotic Inj per 5 mL Sulfamethoxazole 400 mg, trimethoprim 80 mg P carinii pneumonia 15 mg/l day (based on TMP) IV in 3 doses x 21 days (each dose in 250 mL of D5Wover 2 hours). Urinary tract infections and shigellosis 8-10 mg/kg daily based on trimethoprim in 3 equal doses (q8h by IV infusion) for 7 days. 

Oral suspension 40 mg trimethoprim and Various, Bactrim Pediatric 200 mg sulfamethoxazole/5 mL (Rx) (Roche), Septra (GlaxoSmithKline)... 

Trimethoprim (TMP)-Sulfamethoxazole (SMX) [Co-Trimoxa-zole] (Bactrim, Septra) Vancomycin (Vancocin, Vancoled)... 

Trimethoprim (TMP)-Sulfamethmazole (SMX) [Co-Trimoxazole] (Bactrim, Septra) [Antibiotic/Folate Antagonist] Uses un Rx prophylaxis, otitis media, sinusitis, bronchitis Action SMX T synth of dihydro-folic acid TMP T dihydrofolate reductase to impair protein synth Dose Adul. 1 DS tab PO bid or 5-20 mg/kg/24 h (based on TMP) IV in 3-4 doses P. jiroveci ... 

The combined use of sulfonamides or sulfones with dihydrofolate reductase inhibitors, such as trimethoprim Bactrim, Septra) or pyrimethamine Fansidar), s, a good example of the synergistic possibilities that exist in multiple-drug chemotherapy. This type of impairment of the parasite s metabolism is termed sequential blockade. Using drugs that inhibit at two different points in the same biochemical pathway produces parasite lethality at lower drug concentrations than are possible when either drug is used alone. 

Trimethoprim-sulfamethoxazole [co-trimoxazole, TMP-SMZ] (generic, Bactrim, Septra, others)... 

In acute and chronic urinary tract infection, the combination of trimethoprim and sulfamethoxazole (Bactrim, Septra) exerts a truly synergistic effect on bacteria. The sulfonamide inhibits the utilization of p-amino-benzoic acid in the synthesis of folic acid (Figure 2.3), whereas trimethoprim, by inhibiting dihydrofolic acid reductase, blocks the conversion of dihydrofolic acid to tetrahydrofolic acid, which is essential to bacteria in the denovo synthesis of purines, pyrimidines, and certain amino acids. Because mammalian organisms do not synthesize folic acid and therefore need it as a vitamin in their daily diets, trimethoprim-sulfamethoxazole does not interfere with the metabolism of mammalian cells. 

Many other commonly used antibiotics can cause psychiatric symptoms, for example, clarithromycin (trade name, Biaxin)—which is frequently used to treat respiratory illness, ear infections, and skin infections—has been reported to cause mania in some patients. Metronidazole (trade name Flagyl), which is used to treat many types of infections—from parasites to vaginal infections and abscesses—has been reported to cause depression, agitation, confusion, hallucinations, and mania. Trimethoprim-sulfamethoxazole (trade names Bactrim and Septra)—which is used, for example, for bladder infections and sinus and ear infections—has been reported to cause delirium, psychosis, depression, and hallucinations in rare cases. The fluoroquinolone antibiotics—such as ciprofloxacin (trade name Cipro), levofloxacin (trade name Levaquin), ofloxacin (trade name Floxin), trovafloxacin (trade name Trovan), and others of this class—can cause psychiatric symptoms fairly often, including confusion, agitation, depression, insomnia, mania, paranoia, and psychosis. 

Note Although trimethoprim has been known to elicit occasional adverse reactions by itself, it is most commonly used in conjunction with sulfamethoxazole (co-trimoxazole). The trade names for this combination are Bactrim Cotrim Septra. Please see co-trimoxazole for the specific reaction patterns and references... 

Sarafem fluoxetine Septra sulfamethoxazole, trimethoprim, co-trimoxazole... 

The introduction of trimethoprim in combination with sulfamethoxazole constitutes an important advance in the development of clinically effective antimicrobial agents. In addition to its combination with sulfamethoxazole (bactrim, septra, others), trimethoprim also is available as a singleentity preparation (proloprim, others). It is a diaminopyramidine. 

Trimethoprim frequently is used as a single agent clinically for the oral treatment of uncomplicated urinary tract infections caused by susceptible bacteria (predominantly community acquired Escherichia coli and other Gram-negative rods). It is, however, most commonly used in a 1 5 fixed concentration ratio with the sulfonamide sulfamethoxazole (Bactrim, Septra). This combination is not only synergistic in vitro but also is less likely to induce bacterial resistance than either agent alone. It is rationalized that microorganisms not... 

Trimethoprim/ sulfamethoxazole Septra", Bactrim" Stenotrophomonas, Burkholderia 15 mL q 8 hr 6... 

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