Selecting adhesives

Koberstein et al., J.T, Creating smart polymer surfaces with selective adhesion properties. J. Adhes., 66, 229-245 (1998). 

Utilization of cell-specific peptide sequences in biomaterials enables the selective adhesion of certain cell types, even in the presence of a mixture of many cell types. As mentioned earlier, REDV promotes the adhesion of endothelial cells, but not other vascular cell types (Hubbell et al., 1991). This selectivity has great potential for endothelialization of vascular devices, where the growth of an endothelial cells, but not fibroblasts or smooth muscle cells, is desired. Another peptide sequence, KRSR, has been shown to selectively promote the adhesion of osteoblasts, which is useful in the rational design of better dental and orthopedic biomaterials (Dee et al., 1998). 

Ishai O., Rosenthal H., Sela N. and Drukker E. (1988). Effect of selective adhesive interleaving on interlaminar fracture toughness of graphite/epoxy composite laminates. Composites 19, 49-54. 

Dewez JL, Lhoest JB, Detrait E et al. (1998) Adhesion of mammalian cells to polymer surfaces from physical chemistry of surfaces to selective adhesion on defined patterns. Biomaterials 19 1441-1445... 

Selected adhesion molecules represent yet another antibody target. Adhesion molecules, such as LFA-1 (leukocyte function-associated antigen-1) and ICAM-1 (intercellular adhesion molecule 1), play central roles in promoting migration of inflammatory cells to the sites of damage. Such activities underlie many of the symptoms of conditions such as rheumatoid arthritis. Inhibition of adhesion molecule function by administration of antibodies raised against them may, therefore, demonstrate therapeutic potential in some instances. 

For target selection, adhesion molecules are expressed on the surface of endothelial cells. For this purpose, sialyl Lewis X is used as the guide molecule in the case of expression of P- and E-selectins for TNFa-activated HUVEC (human umbilical vein endothelial cells). Thus, targeting membrane-bound antigens in situ is also possible with this technique. 

Plouffe BD, Njoka DN, Harris J et al (2007) Peptide-mediated selective adhesion of smooth muscle and endothelial cells in microfluidic shear flow. Langmuir 23(9) 5050-5055... 

Basically, there are two major considerations when one is formulating or selecting adhesives or sealants for low-temperature applications. The first is the effect of the low temperature on the bulk properties of the polymer, and the second is the effect of thermal cycling and resulting internal stresses on the joint interface. 

Selective adhesion molecule inhibitor produced in murine myeloma cells, binds to o 4-submunit of human integrin which is highly expressed on the surface of all leukocytes, with exception of neutrophils and blocks the interaction with vascular cell adhesion molecule-1 (ICAM-1)... 

Cellular adhesion FFF combines the controllable hydrodynamic shear forces of FFF and the selective adhesion of AC. The hydrodynamic shear is used to detach selectively and evenly adhered cells or particles from the surface and allows an estimation of the differences in cell/surface adhesion forces. The channel for cellular adhesion FFF is constructed in the same way as that used for Gr-FFF but is smaller in size and with the modification that the accumulation wall consists of either bare or polymer-coated surfaces. After the cell suspension is filled into the channel allowing sufficient time for cell adhesion, the flow is applied and fractions are collected. Despite the collection of fractions, cellular adhesion FFF can also be used as a tool to study rapid kinetics of cell surface adhesion, a largely unexamined area [332]. 

A 1 X 1 inch Prolene mesh was rinsed with 0.5 wt% of NaHCOs and dried. The mesh was then placed on a freshly prepared Agar plate in a petri dish and roughly 100 mg of a selected experimental adhesive applied across the mesh. The selected adhesive was cured overnight then sealed with parafilm the film thickness was about 0.6 mm. 

Marchi-Artzner V, Lorz B, Hellerer U, Kantlehner M, Kessler H, Sackmann E. Selective adhesion of endothelial cells to artificial membranes with a synthetic RGD-lipopeptide. Chemistry 2001 7 1095-1101. 

Hot asphalt applications had been used for many years in concrete tanks, inner lined with brick for similar service, and also, of course, unlined wood tanks made from timber, and small pickling tanks made by hollowing out cavities in granite blocks. But the use of hot asphalt as a liner for steel tanks had been unsatisfactory due to the erratic cold flow of the asphalt which demonstrated selective adhesion to steel and so would tear and open cracks in the membrane system in the areas of cold flow below the points where it adhered. To overcome this difficulty, a number of inventive persons experimented with the manufacture of asphalt sheet lining materials, similar in form to the sheets of natural rubber, in which the asphalt was compounded with various admixtures, including rubber. These asphaltic compound sheets were then warmed sufficiently to make... 

Klouche M, May A E, Hemmes M, et al. (1999) Enzymatically modified, nonoxidized LDL induces selective adhesion and transmigration of monocytes and T-lymphocytes through human endothelial cell monolayers. Arterioscler ThrombArterioscler Thromb Vase Biol 19 784-793... 

The selective adhesion of leukocytes to the endothelium near sites of infection or inflammation thus depends on the sequential appearance and activation of several different CAMs on the surfaces of the interacting cells. Different types of leukocytes express specific Integrlns containing the (52 subunit for example, aL(52 by T lymphocytes and ctM(52 by monocytes, the circulating precursors of tissue macrophages. Nonetheless, all leukocytes move into tissues by the same general mechanism depicted in Figure 6-30. 

Table 1 hsts some common types of adhesives and their uses. Because of the different possible substrates and combinations of substrates, and because adhesives are subject to such a range of environmental conditions, it is no wonder that there are so many types of adhesives on the market. However, if one has some knowledge of how adhesives bond to substrates and the types of substrates being bonded, the task of selecting adhesives will not be overwhelming, see also Bonding Pauling, Linus. 

Townes, P. Holtfretter, ]. (1955). Directed movements and selective adhesion of embryonic amphibian cells. J. Exp. Zoo/., 128, 53-120. 

It is convenient to compare and select adhesives in terms of their resistivities because these values reduce resistance measurements to a common denominator. Volume resistivity, which is the ohmic resistance of a cube of bulk material 1 cm per side, is frequently used to compare the electrical properties of both electrically conductive and electrically insulative adhesives. 

Selecting adhesives that have high thermal conductivities. 

In contrast to aluminum and titanium structural bonds where performance can be optimized for most aerospace applications, steel bonds are often designed to minimize cost as long as certain performance standards are met [47]. If feasible, many manufacturers prefer to select adhesives or primers that provide adequate strength and durability with untreated steel rather than to prepare the surface for bonding. 

There have been efforts to put scanning tips to different uses in which the scanning probe is employed neither as an electrode nor as a monomer/CP delivery mechanism, but as a nanomechanical tip to create scratches on a substrate to guide the growth or promote selective adhesion of CP nanofeatures. For example, it has been shown that a tip can be used to scratch the poly(methyl methacrylate) (PMMA) layer on top of electrolyte and catalyst underlayers to achieve selective chemical polymerization of pyrrole monomer on... 

K. J. Froelich and C. M. Fitzpatrick, Lap Shear Strength of Selected Adhesives (Epoxy, Varnish, B-Stage Glass Cloth) in Liquid Nitrogen and at Room Temperature, ORNL-TM-5658, Oak Ridge National Laboratory, Oak Ridge, Tennessee (1976). 

P. D. Drumheller, D. L. Elbert, J. A. Hubbell, Multifunctional Poly(Ethylene Glycol) Semi-interpenetrating Polymer Networks as Highly Selective Adhesive Substrates for Bioadhesive Peptide Grafting. Biotechnol. Bioeng. 1994, 43, 772-780. 

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