Membrane as target

Mention has been made of thiol groups in the cytoplasmic membrane as targets for certain antibacterial compounds. Thiol groups also occur in the cytoplasm and these groups will also serve as targets. 

In contrast, much recent evidence suggests that these supposedly nonspecific agents might act by binding directly to a particularly sensitive protein, rather than a phospholipid membrane, as target (Franks and Lieb,... 

Bastianon, C., Zanoni, R., Miolo, G., Caffieri, S., 6c Reddi, E. (2005). Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine. International Journal of Biochemistry Cell Biology 37, 901—908. 

THE CONNECTIVE TISSUE MATRIX AND BASEMENT MEMBRANE AS TARGETS FOR SULPHUR MUSTARD ATTACK... 

King, J.R., Peters, B.P., and Monteiro-Riviere, N.A., 1994, Matrix molecules of the epidermal basement membrane as targets for chemical vesication with lewisite, Toxicol. Appl. Pharmacol., 126 164—173. 

TOXINS WITH PLASMA MEMBRANE AS TARGET OF ACTION... 

The seminal work by early transplant researchers eventually led to the concept of histocompatibility.1,2 Histocompatibility describes the process where polymorphic genes encode cell membrane antigens that serve as targets for immune response, even within a species. Further research in transplant immunobiology has led to an accurate understanding of the immune response after transplantation.1,2... 

Narahashi T (1992) Nerve membrane Na+ channels as targets of insecticides. Trends Pharmacol Sci 13 236-241... 

Another series of GSL mimics with oligo-ethylene glycol as spacer have also been obtained successfully using trichloroacetimidate method [482]. In addition, fluorescence-labeled sLex glycosphingolipids have also been chemically synthesized as targets for investigating microdomain formation in membranes [483]. 

The initial adherence of pathogens to host cell surfaces is considered an essential step in colonization and infection (Savage, 1977, 1984). Therefore, identifying the bacterial molecules that mediate adherence has been a major area of research, especially since these molecules may serve as targets for anfi-adherence strategies. As discussed previously (Section VI), the detailed interactions between a pathogen and a host cell are often mediated by proteinaceous surface structures on the bacterial surface. These bacterial proteins are referred to as adhesins (Finlay and Falkow, 1989), and are most often foimd on the tips of bacterial fimbriae or pili (fimbrial adhesins), but may also be anchored in the bacterial membrane so that it can be presented on the bacterial outer membrane (afimbrial adhesins) (Sharon and Ofek, 1986). Models of fimbrial and afimbrial adhesins of some human pathogens are discussed here. 

Endo K, Igarashi Y, Nisar M, Zhou QH, Hakomori S (1991) Cell membrane signaling as target in cancer therapy inhibitory effect of N,N-dimethyl and N,N,N-trimeth)d sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res 51 1613-1618... 

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