Macrophages tissues

Macrophage markers Short-finned pilot whale and Risso s dolphin Tissue macrophages Cross-reactive [101]... 

Schreiber, A. D., Rossman, M. D., Levinson, A. I. (1992). The immunobiology of human Fc/receptors on hematopoietic cells and tissue macrophages. Clin. Immunol. Immunopathol. 62, S66-72. 

Further support to the notion that liposomal BPs exert their effects systemically was achieved through the use of liposomes loaded with the fluorescent marker, Rhodamine, with or without a BP (52,69). Marked reduction of the fluorescent signal was observed in blood monocytes (as well as reduced number) and in the liver and spleen of LBP-treated animals. Fluorescent liposomes (FL) were detected in injured but not in intact arteries. FL coadministered with LBPs significantly reduced the fluorescent signal in the injured arterial wall. The inactivation of monocytes after systemic administration of LBPs results in reduction of tissue macrophages in the injured artery. Thus, the outcome of systemic administration was manifested as local treatment for the injured artery. 

M. G. Cecchini, M. G. Dominguez, S. Mocci, A. Wetterwald, R. Felix, H. Fleisch, 0. Chisholm, W. Hoffstetter, J. W. Pollard, and E. R. Stanley, Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development no, 1357-1372 (1994). 

Kupffer cells are the largest reservoir of fixed-tissue macrophages and are quantitatively the most important cell type for the removal of circulating microorganisms, EPS, tumour cells. 

T-helper lymphocytes Blood monocytes Tissue macrophages... 

Pyrazinamide is well absorbed from the GI tract and is widely distributed throughout the body. It penetrates tissues, macrophages, and tuberculous cavities and has excellent activity on the intracellular organisms its plasma half-life is 9 to 10 hours in patients with normal renal function. The drug and its metabolites are excreted primarily by renal glomerular filtration. 

Glucocorticoids inhibit the functions of leukocytes and tissues macrophages. They also stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes at the site of inflammation. 

It is concluded that chronic leg ulcer patients probably lack the mechanisms that normalise their levels of antioxidant enzymes, which normally decrease at early stages of wound healing in order to allow blood granulocytes and tissue macrophages to perform their function in cleansing the wounded area. Consequently re-epitheUalisation and matrix remodeling processes are delayed. LLLT stimulates... 

Hellmann, J., Tang, Y., Kosuri, M., Bhatnagar, A., and Spitem, M. (2011). Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J. 25, 2399-2407. 

---