Nuclear Regulator

J. S. Walker, M Short FTstory of Nuclear Regulation, 1946—1990, Nuclear Regulatory Commission, Rockville, Md., Jan. 1993. 

DeGroot, R. and Sassone-Corsi, P. Hormonal control of gene expression Multiplicity and versatility of cyclic adenosine 3, 5 -monophosphate-responsive nuclear regulators. Mol. Endocrinol. 8 145-153,1993. 

Wei, N., Deng, X. W. Characterization and purification of the mammalian COP9 complex, a conserved nuclear regulator initially identified as a repressor of photomorphogenesis in higher plants. Photochem. Photobiol. 1998, 68, 237-241. 

The functions of these fusion proteins and their precise roles in the induction of cancer are currently the subject of intense investigation (Collins et al., 2006 Huntly et al., 2004 Kindle et al., 2005). In general, it appears that since the proteins are fused in-frame, their catalytic domains continue to function, but these activities are mis-directed by the targeting domains of their fusion partners. The result is aberrant acetylation of chromatin and non-chromatin proteins, as well as sequestration of key nuclear regulators. These mechanisms are discussed in-depth in Chapter 8 of this book. Furthermore, two recent studies have demonstrated that wild-type MOZ is essential for development of hematopoietic stem cells (Katsumoto et al., 2006 Thomas et al., 2006). This suggests that AML may arise not only due to the aberrant activity of the fusion proteins, but also due to the loss of their original function. 

In the United States, the last plant start up was in 1996, but in 2006-2007 some 20 new permit applications were submitted, including one at Calvert Cliffs, Maryland, by UniStar and others by Constellation Energy, Areva (French-German firm), and NRG. In addition, the Tennessee Valley Authority applied to build in Alabama, and Dominion applied in Virginia. The first application to go before the Nuclear Regulating Commission is the NRG plant to be built in Texas. 

Week 8 Nuclear energy Federal nuclear regulations... 

Since the launch of its nuclear use and development programme, Japan has limited nuclear uses to peaceful purposes and has managed the programme under a strict domestic control system. In response to the ratification of the NPT in 1976, the government amended the Nuclear Regulation Law and set up a national system which enabled the country to cope with the IAEA s full scope safeguards. An outline of the system is shown in Fig. 11.2. 

Japan s nuclear source materials and nuclear fuel materials, which support this nuclear power generation, are all subject to safeguards under the Nuclear Regulation Law and the NPT. At the end of 1992, Japan held roughly 35001 of natural and depleted uranium, about 94001 of low enriched uranium (LEU) and 33.5 t of plutonium. Figure... 

In August 1993, the number of facilities which deal with nuclear materials under safeguards reached 248, including the major facilities indicated in Fig. 11.3. The Nuclear Regulation Law mandates all of these facilities to receive permits for installation, business, use and change. In addition, the Law mandates that these facilities receive permits for procedures which stipulate the implementation of strict accountancy within these facilities. A breakdown of the types of facilities is indicated in Table 11.6 (after Hayashi et al., 1994). 

The NEA TDB Phase II objectives were formulated by the 17 participating organisations coming from the fields of radioactive waste management and nuclear regulation. The TDB Management Board is assisted for technical matters by an Executive Group of experts in chemical thermodynamics. In this second phase of the Project, the... 

Nuclear Regulation Reporter, Commerce Clearing House, Chicago, IL. 

Although most of the effects of TH are mediated by nuclear regulation of target mRNA expression, there is clear evidence of additional nongenomic, rapid (seconds or minutes) actions ofT3 andT4 (Davis et al, 2002). 

EUR 19265 EN Common position of European nuclear regulators for the licensing of safety critical software for nuclear reactors. May 2000... 

AR261 Investing in trust Nuclear regulators and the public Nuclear Regulation, Workshop proceedings, Paris, 29 November-1 December 2000. 

Mazuzan, G.T. and Walker, J.S. (1984) Controlling the Atom, The Beginning of Nuclear Regulation 1946-1962. University of California Press. 

OECD. (2002). PROCEEDINGS [NEA/CSNI/ R(2002)3]. INTERNATIONAL WORKSHOP BUILDING THE NEW HRA ERRORS OF COMMISSION FROM RESEARCH TO APPLICATION 7-9 May 2001. Rockville US Nuclear Regulation Commission. 

Rosen, E. D., and B. M. Spiegelman. 2001. PPARgamma A nuclear regulator of metabohsm, differentiation, and cell growth. JBiolChem 276 (41) 37731. ... 

The tighter bounds on the SAW DDR reduced the uncertainty in the irradiated fracture toughness. This approach was subjected to rigorous peer review before acceptance by the Nuclear Regulator. It was successful in maintaining the margins for on-upper-shelf operation at critical locations. 

In Canada, the Environmental Review Process includes public hearings and no approval will be granted without public hearings. Furthermore no license will be granted until the nuclear regulator is satisfied that the plant is safe, and that the public has had the opportunity to comment on the plant. 

U.S. Nuclear Regulator Commission (NRC). 1980. Criteria for Preparedness and Evaluation of Radiological Emergency Plans and Preparedness in Support of Nuclear Power Plants, NUREG-0654, Rev... 

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