Sarcoma 180 ascites

The significance of these in vitro enzyme inhibition studies is uncertain, in view of the evidence that has been presented concerning the sensitivity of cancer cells to feedback inhibition by these nucleotides. On the other hand, 6-chloropurine inhibits the de novo biosynthesis of nucleic acid guanine but not of nucleic acid adenine in sarcoma 180 ascites cells [319],... 

In addition to the (antimicrobial, enzyme and endocrine related) properties mentioned above, it is interesting that many labdane type diterpenes also exhibit significant properties against cancer cells. A number of labdane type diterpenes tested exhibited remarkable antiproliferative and cytotoxic activities. Itokawa et al. [193] found that extracts from the rhizomes of Hedychium coronarium (Zingiberacae), cause growth inhibition of Chinese hamster V-79 cells and sarcoma 180 ascites in mice. Chemical analysis led to the isolation of 8 (17), 12 (E)-labdadiene-15, 16-dial along with four new coronarins (A-D). All of the compounds exhibited... 

Table 11. Antitumor activity of 5-FU and polymeric drugs against subcutaneous type of Sarcoma 180 ascites tumor cells1.

Sarcoma-180 ascites Swiss white mice 100 % cures... 

The nucleosides 236 were evaluated for cytotoxicity on mouse lymphoid leukemia cells (84JMC1358). Compounds 242 were screened for their anticancer or anti-AIDS activities (91JHC1417). Anticarcinogen activity against sarcoma 180 ascite tumor cells in mice was shown by 90 [84JAP(K) 5962593]. 

SiZOfiran [inn.jan] (schizophyllan SPG) is a (polysaccharide) antibiotic, isolated from Schizophyllum commune, showing (immunostimulant) immunomodulator activity. It has ANTICANCER activity in a number of systems, including against sarcoma-180 ascites, and also augments anticancer properties of interleukin-2 in mice. 

Annona senegalensis stem bark is used for the treatment of hysteria and a constituent of its root bark has been found efiective for treating cancer using sarcoma 180 ascites cells (75). The bark and root are used in the treatment of sexually transmitted diseases (18). The root bark contains cardenolides, glycosides and saponins. The stem bark contains anthranoids, cardenolides, glycosides saponins and terpenoids (50,18). Its fraits are edible and are taken for diarrhoea, dysentery and vomiting (23,33). 

Table VIII Antitumor Activity on Sarcoma 180 Ascites in Mice...

Astins A-C, containing chlorines and an a//o-Thr and characterized by one cis peptide bond, showed antitumor activity, as determined by the total packed cell volume method using Sarcoma 180 ascites in mice (195). The effectiveness of this activity was evaluated in terms of the tumor growth ratio (GR(%) = (test group packed cell volume/control group packed cell volume) X 100). The GR values of astins A, B, and C were 40% (++) at... 

Bekesi, J. G., and Winzler, R. J. The effect of D glucosamine on the adenine and uridine nucleotides of Sarcoma 180 ascites tumor cells. J. Biol. Chem., 244 5663-5668, 1969. 

Metab. from a strain of Leptosphaeria sp. Exhibits potent cytotoxicity against P388 lymphocytic leukaemia cells and significant antitumour activity against Sarcoma 180 ascites. Pale yellow powder. Mp 208-210°. [a]jj +237 (c, 0.36 in CHCI3). 

Oxidation of 4-acetoxy-l-methylisoquinoline (76) with selenium dioxide produced the corresponding 1-carboxaldehyde, which upon acid hydrolysis yielded the 4-hydroxy derivative. Treatment of heterocyclic aldehydes with thio-semicarbazide produced the desired thiosemicarbazones. In general, the 4-substituted derivatives were less effective than (1) as antineoplastic agents against Sarcoma 180 ascites cells in mice however, the sodium salt of the 4-hydroxy derivative was considerably more efficacious than (1) against the L-1210 lymphoma. 

Two of the derivatives (i.e., those containing 5-methylamino and 5-ethyl-amino groups) demonstrated impressive antitumour activity against Sarcoma 180 ascites cells and several others were potent inhibitors of ribonucleoside diphosphate reductase, requiring concentrations in the range of 10" to 10" M for 50% inhibition [43], 5-Methylamino-l-formylisoquinoline thiosemicarbazone, which was the most effective of the newly synthesized compounds required a concentration of 3 10" M for 50% inhibition of reductase activity and increased the life span of tumour-bearing mice over untreated animals by a factor of 2.5 at the optimal daily dose. 

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