Tumour bearing mice

Jagetia, G. C., Baliga, M. S Venkatesh, P., Ulloor, J. N Mantena, S. K Genebri-era, J. and Mathuram, V. 2005. Evaluation of the cytotoxic effect of the monoter-pene indole alkaloid echitamine in vitro and in tumour-bearing mice. The Journal of Pharmacy and Pharmacology, 57(9) 1213-1219. 

Groups of 48 male and 48 female CFl mice were painted with either approximately 0.05-0.1 mL per mouse toluene or 1,3-propane sultone in toluene administered as a single application of 2.5% or 25% w/v or as 10 applications of a 2.5% w/v solution on alternate days. The experiment was terminated after 78 weeks. No skin tumour was found in the toluene controls of either sex, whereas in the 1,3-propane sultone-treated groups, the numbers of tumour-bearing mice were single application of 2.5%, 0/48 males and 1/48 females 10 applications of 2.5%, 3/48 males and 2/48 females single application of 25%, 29/36 males and 26/46 females (Doak et al., 1976). 

Ishida, O., Maruyama, K., Sasaki, K., and Iwatsuru, M. (1999), Size-dependent extravasation and interstitial localization of polyethyleneglycol liposomes in solid tumour-bearing mice, Int. J. Pharm., 190,49-56. 

In vivo experiments in normal and tumour-bearing mice were also performed with (III.157) [45]. In contrast to 5,8-dideazaAMT (III.147), which had a single-dose LDjq in mice of 2-4 mg/kg and produced significant antitumour activity against L1210 leukaemia in mice (see above), (III.157) was non-toxic... 

Elevated serum copper levels were also found in dogs with radiation-induced and spontaneous osteosarcoma [353]. No clinical signs of metastasis were observed following tumour removal, by limb amputation, and there was a return to normal or near-normal serum copper levels. Dogs with nonmalig-nant nonosteosarcoma lesions were found to have normal serum copper levels. Detailed studies of altered copper metabolism in tumour-bearing mice and rats have also been recently reviewed [354]. 

Kallio, A. and Janne, J. (1983) Role of diamine oxidase during the treatment of tumour-bearing mice with combinations of polyamine antimetabolites. Biochem. J. 212 895-898. 

Queiroz, M.L.S., M.C. Valadares, C.O. Toiello, et al. 2008. Comparative studies of the effects of Tabebuia avellanedae bark extract and (i-lapachone on the hematopoietic response of tumour-bearing mice. /. Ethnopharmacol. 117(2) 228-235. 

Figure 1.6. Doxorubicin in tumour-bearing mice, either as the free drug (open symbols/dashed lines) or in liposomes consisting of distearoylphosphatidylethanolamine-PEO/hydrogenated soy phosphatidylcholine/cholesterol (0.2 2 1 mol/mol) (filled symbols/continuous lines) (data from ref. (57))...

Fig. 2 Transmission electron micrographs and co-registered in vivo optical luminescence (Cherenkov radiation) and X-ray transmission images in tumour-bearing mice (1 h and 24 h post-dose, tumours marked with a circle) of Au nanoparticles of varying morphologies including (a) spheres (b) disks (c) rods and (d) cages. Spherical morphologies show the best performance in terms of blood circulation, clearance and tumour uptake compared with disks, rods and cages. Reprinted with permission from Black et al. ACS Nano, 2014, 8(5) 4385-4394. Copyright (2014) American Chemical Society.

Figure 7.5 In vivo PDT treatment of 4T1 tumour-bearing mice. Survival curves of 4T1 breast tumour-bearing mice 60 days after various treatments no nanoparticles and no irradiation - saline (blue) no nanoparticles and NIR irradiation - saline + laser (red) treatment with UCNP-Ce6-com-plex and no irradiation - UCNP-Ce6 only (green) and treatment with UCNP-Ce6-complex and NIR irradiation - UCNP-Ce6 + laser (purple). 10 mice were used in each group. Figure adapted from Wang et oL, Near-infrared light induced in vivo photodynamic therapy of cancer based on UCNPs, Biomaterials, 2011, 32, 6145-6154. Copyright (2011) with permission from Elsevier. ...

Two of the derivatives (i.e., those containing 5-methylamino and 5-ethyl-amino groups) demonstrated impressive antitumour activity against Sarcoma 180 ascites cells and several others were potent inhibitors of ribonucleoside diphosphate reductase, requiring concentrations in the range of 10" to 10" M for 50% inhibition [43], 5-Methylamino-l-formylisoquinoline thiosemicarbazone, which was the most effective of the newly synthesized compounds required a concentration of 3 10" M for 50% inhibition of reductase activity and increased the life span of tumour-bearing mice over untreated animals by a factor of 2.5 at the optimal daily dose. 

Maximum tolerated dose in tumour-bearing mice. 

In Ehrlich ascites tumour-bearing mice. Consult References 100 and 105 for details. 

A similar method was used (36) to estimate cyclophosphamide (29) in the serum, urine and tissues of tumour-bearing mice using isophosphamide (30) as the internal standard. Both compounds... 

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