Paramyxoviridae family

Respiratory syncytial vims is another member of the Paramyxoviridae family of viruses that has been considered for new vector development. RS V mediates cell entry through its glycoproteins G and F (215). Like SeV, transcription and replication are cystoplasmic events. In preliminary studies, a replication-competent RSV-GFP virus eflSciently transduced WD FIAE cells following apical, but not basolateial, application of vector (203). RS V will likely have similar limitations as SeV for vector development. However, SeV and RSV offer exciting promise for future human airway gene transfer efforts. 

The structure of the Ebola virus matrix protein (VP40) has been determined (Dessen et al, 2000). It has two domains of the same, unique topology (Fig. 10) consisting of sandwiches made from two three-stranded antiparallel / sheets. The topology bears no resemblance to other viral matrix proteins of known structure. Indeed, differences in the sequence suggest that it might be different from the closest related of other families, including Paramyxoviridae and Rhabdoviridae (Dessen et al, 2000). 

Measles virus, genus morbillivirus, family paramyxoviridae... 

Hendra virus (formerly called equine morbillivirus) is a member of the family Paramyxoviridae. The virus w as first isolated in 1994 from specimens obtained during an outbreak of respiratory and neurologic disease in horses and humans in Hendra, a suburb of Brisbane, Austialia. 

Nipah virus, also a member of the family Paramyxoviridae, is related but not identical to Hendra virus. Nipah virus was initially isolated in 1999 upon examining samples from an outbreak of encephalitis and respiratoi illness among adult men in Malaysia and Singapore. 

---