Carbohydrate-recognition domains

C-type lectins Characterized by a Ca +-dependent carbohydrate recognition domain (CRD) includes the mammalian asialoglycoprotein receptor, the selectins, and the mannosebinding protein... 

CLECT C-type lectin (CTL) or carbohydrate-recognition domain (CRD) E(M) 0(0) 246(314) 1B6E... 

The precise chemical interactions between an adhesin and its receptor are also important. For example, direct- and water-mediated hydrogen bonds are the most important interactions within the carbohydrate-recognition domain in carbohydrate-binding adhesins on the host cell surface (Weis and Drickamer, 1996). Nonpolar van der Waals interactions and hydrophobic "stacking of the receptor oligosaccharide rings with aromatic amino acid side chains of the bacterial adhesin protein also contribute to oligosaccharide-protein interactions. X-ray structural... 

Figure 13.2 The crystal structures of (a) concanavalin A and (b) the carbohydrate recognition domain of galectin-3. Residues in the carbohydrate binding sites are black.

Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes SH, Rini JM. X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1 A resolution. J Biol Chem 1998 273 13047-13052. 

A number of carbohydrate recognition domains (CRDs) of animal lectins are known to exist as clusters. ASGP-Rs exist as bundle of hexamers, mannose 6-phosphate receptor and galectin-3 are known as dimers, while mannose binding proteins and receptors form multiple CRDs [31]. 

K. Drickamer, Two distinct classes of carbohydrate-recognition domains in animal lectins, J. Biol. Chem. 263 9557 (1988). 

Feinberg, H., Park-Snyder, S., Kolatkar, A. R., Heise, C. T., Taylor, M. E., and Weis, W. I. (2000). Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor./. Biol. Chem. 275(28), 21539-21548. 

Lectins refer to all of the proteins that have carbohydratebinding abilities. Carbohydrate recognition domain (CRD) is the functional part in lectins for sugar binding. Based on fhe structural diversify of CRD, lectins are classified as L-,... 

McGreal EP, Rosas M, Brown GD, Zamze S, Wong SYC, Gordon S, Martinez-Pomares L, Taylor PR. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 2006 16 422-430. 

Pichierri, F, Matsuo, Y, Effect of protonation of the A-acetyl neuraminic acid residue of sialyl Lewis a molecular orbital study with insights into its binding properties toward the carbohydrate recognition domain of E-selectin, Bioorg. Med. Chem. Lett., 10, 2751-2757, 2002. 

C-Type lectins were named after their requirement of calcium ions for recognition. They are all characterized by an extracellular carbohydrate recognition domain (CRD) and bind a diver-... 

Abbreviations CRD, carbohydrate recognition domain ER, endoplasmic reticulum... 

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