Research definition

To ensure that the rights and welfare of human research participants are protected, the IRB takes on the task of performing a risk vs. benefit analysis. Before a clinical trial can be initiated, foreseeable risks and inconveniences should be weighed against the anticipated benefit for the trial participant and for society (Section 22.2). Risks associated with participation in research should be justified by the anticipated benefits only then, can the trial be initiated. Because this requirement is clearly stated in the federal regulations, it is, therefore, one of the major responsibilities of fhe IRB to assess fhe risks and benefits associated with proposed research. Definitions of fhe terms fhaf fhe IRB uses to assess risk include the following ... 

NIH Definitions Working Group. Biomarkers and surrogate endpoints in clinical research Definitions and conceptual model. In Downing GL, ed. Biomarkers and surrogate endpoints Clinical research and applications. Amsterdam Elsevier 2000. p. 1-9. 

The limitations related to the applicability of Greimas model are twofold. First, as an anal5 tical tool, although Greimas model may appear clear and simple, it may prove to be rather complicated as there are no definitions to identify the actants. The construction of the relationships between the actantial units of the text is always relative, and depends on the researchers definitions. The semiotic analysis requires close assessment and a clear interpretation of the revealed meanings. However, despite the present limitations, the present results support the proposal that Greimas model can be used as a theoretical framework and as practical semiotic tool describing the corporate sustainability . 

Prigogine and his coworkers considered that their results from these several research initiatives were mutually reinforcing — and that their most recent research definitely established that the origin of irreversibility is local rather than global in character. 

The sensitivity to defects and other control parameters can be improved by optimizing the choice of the probe. It appears, after study of different types of probes (ferritic, wild steel, insulator) with different geometries (dish, conical,. ..), necessary to underline that the success of a feasibility research, largely depends on a suitable definition of measure collectors, so that they are adapted to the considered problem. 

The resistance to nucleation is associated with the surface energy of forming small clusters. Once beyond a critical size, the growth proceeds with the considerable driving force due to the supersaturation or subcooling. It is the definition of this critical nucleus size that has consumed much theoretical and experimental research. We present a brief description of the classic nucleation theory along with some examples of crystal nucleation and growth studies. 

C and T E Klein 1986. Molecular Graphics and QSAR in the Study of Enzyme-Ligand ractions. On the Definition of Bioreceptors. A ccounts of Chemical Research 19 392-400,... 

The term theoretical chemistry may be defined as the mathematical description of chemistry. The term computational chemistry is generally used when a mathematical method is sufficiently well developed that it can be automated for implementation on a computer. Note that the words exact and perfect do not appear in these definitions. Very few aspects of chemistry can be computed exactly, but almost every aspect of chemistry has been described in a qualitative or approximately quantitative computational scheme. The biggest mistake a computational chemist can make is to assume that any computed number is exact. However, just as not all spectra are perfectly resolved, often a qualitative or approximate computation can give useful insight into chemistry if the researcher understands what it does and does not predict. 

There is no official or universally accepted definition of what constitutes a "microemulsion." In fact, for several years, some leading scientists in microemulsion research considered the term to be an unnecessary and even an unfortunate one. Nevertheless (Table 1), during the years from about 1975 to 1980 the word ascended from obscurity to ubiquity. By the end of 1996 there were 13 widely available Knglish-language books (1 9) with the word "Microemulsion" in their tides (10). About 70 more books on surfactants are in print, of which those on industrial appHcations (9,11—18), and environmental effects (19—21) are of particular interest here. 

In order to maintain a definite contact area, soHd supports for the solvent membrane can be introduced (85). Those typically consist of hydrophobic polymeric films having pore sizes between 0.02 and 1 p.m. Figure 9c illustrates a hoUow fiber membrane where the feed solution flows around the fiber, the solvent—extractant phase is supported on the fiber wall, and the strip solution flows within the fiber. Supported membranes can also be used in conventional extraction where the supported phase is continuously fed and removed. This technique is known as dispersion-free solvent extraction (86,87). The level of research interest in membrane extraction is reflected by the fact that the 1990 International Solvent Extraction Conference (20) featured over 50 papers on this area, mainly as appHed to metals extraction. Pilot-scale studies of treatment of metal waste streams by Hquid membrane extraction have been reported (88). The developments in membrane technology have been reviewed (89). Despite the research interest and potential, membranes have yet to be appHed at an industrial production scale (90). 

A low temperature of approach for the network reduces utihties but raises heat-transfer area requirements. Research has shown that for most of the pubhshed problems, utility costs are normally more important than annualized capital costs. For this reason, AI is chosen eady in the network design as part of the first tier of the solution. The temperature of approach, AI, for the network is not necessarily the same as the minimum temperature of approach, AT that should be used for individual exchangers. This difference is significant for industrial problems in which multiple shells may be necessary to exchange the heat requited for a given match (5). The economic choice for AT depends on whether the process environment is heater- or refrigeration-dependent and on the shape of the composite curves, ie, whether approximately parallel or severely pinched. In cmde-oil units, the range of AI is usually 10—20°C. By definition, AT A AT. The best relative value of these temperature differences depends on the particular problem under study. 

Given stringent requirements for effective sensitizers and the desire to use wavelengths further to the red for therapeutic appHcations, definition of newer sensitizers has been a principal area of research since about 1987. Expanded theoretical and experimental understanding of photophysics has been a key element in identifying new classes of potential sensitizers (93—98). Research has focused on cationic derivatives of Nile Blue (93), metaHo-phthalocyanines (94), naphthalocyanines (95), chlorin-type compounds (96), expanded ring porphyrinoids (97), as well as porphyrins other than hematoporphyrin and its derivatives (98). This work has also been reviewed (10,91). Instmmentation for photodynamic therapy has been reviewed (99). 

To avoid confusion, several researchers have incorporated therapeutic intention into the definition of controlled release (4—7). Thus, controUed-release pharmaceuticals release dmgs in vivo according to a predictable, therapeutically rational, programmed rate to achieve the optimal dmg concentration in the minimal time (4). Specification by release rate complements specification by quantity jointly considered, they fix the duration of dmg release. Therefore, the dmg s duration of action can become a design property of a controlled release dosage form rather than an inherent pharmacokinetic property of the dmg molecule. 

The basis of all bulk conveyor engineering is the precise definition and accurate classification of materials according to individual characteristics under a specific combination of handling conditions (1). Since the late 1960s there has been an extraordinary growth in research into the fundamental properties and behavior of particulate soHds. However, as of this writing, it is not possible to predict the handling behavior of a bulk soHds material relevant to conditions in a specific conveyor, merely on the basis of the discrete particle properties. 

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