Design properties

To avoid confusion, several researchers have incorporated therapeutic intention into the definition of controlled release (4—7). Thus, controUed-release pharmaceuticals release dmgs in vivo according to a predictable, therapeutically rational, programmed rate to achieve the optimal dmg concentration in the minimal time (4). Specification by release rate complements specification by quantity jointly considered, they fix the duration of dmg release. Therefore, the dmg s duration of action can become a design property of a controlled release dosage form rather than an inherent pharmacokinetic property of the dmg molecule. 

A. F. Johnson, Engineering Design Properties of GFRP, British Plastics Federation, 1974. 

DESIGN, PROPERTIES, AND TESTING OF POLYMER STANDARDS SERVICE SIZE EXCLUSION CHROMATOGRAPHY (SEC) COLUMNS AND OPTIMIZATION OF SEC SEPARATIONS... 

Moreover, polymer applications determine a number of important column (hardware) design properties to get reproducible results and the most efficient separations. Most of them are related to the polymer conformation in the injection band moving through the column. 

It is the prediction of performance in its broadest sense, including all the characteristics and properties of materials that are essential and relate to the processing of the plastic. To the designer, an example of a strict definition of a design property could be one that permits calculating product dimensions from a stress analysis. Such properties obviously are the most desirable upon which to base material selections. 

Moisture or water absorption is an important design property. It is particularly significant for a product that is used in conjunction with other materials that call for fits and clearances along with other close tolerance dimensions. 

This unified approach to polymer materials science is divided into three major sections Basic Principles, Influence of Processing on Properties, and Engineering Design Properties. 

P. Kilz, Design, Properties and testing of polymer standards service size Exclusion chromatography (SEC) columns and optimization of SEC separations, in Column Handbook for Size Exclusion Chromatography, C.-s. Wu, ed.. Academic Press, San Diego, CA, 1999, p. 267. 

Though there are many possibilities of the engineering alloys, let us consider three common alloys from different classes a steel, an aluminum alloy, and a titaninm alloy. The three alloys and their appropriate design properties are listed in Table 8.3. The values that are the most favorable in each category are listed in bold typeface. On the basis of Criterion 1, the best material is maraging steel, but from the viewpoints of Criteria 2 and 3 the titanium alloy is obviously superior. Cost is an additional factor that could influence the final selection. 

The optimum or minimum allowable substitution ratio is then established by means of a series of justification tests at different binder contents. Figure 15 shows a comparison between the Marshall design properties of a conventional mixture using an asphalt binder and a 30 70 SEA binder. As indicated the optimum substitution ratio based on the maximum stability and equivalent air voids is about 1.7 1. Since minimizing the substitution ratio has a direct impact on the economic benefits to be realized by replacing the asphalt with sulfur these justification tests are to be recommended in all mix designs. 

Designating property-based guidelines for designing chemicals such that they are minimally absorbed and, therefore, should be less toxic, is analogous to a known phenomenon in medicinal chemistry - designing drug compounds such that they are likely to be well absorbed into the body to optimize the desired pharmacological effect. 

Micronization with supercritical fluids - Crystallization - Rapid expansion - Gas anti-solvent Recrystallization - Precipitation with compressed anti-solvent - Solution-enhanced dispersion - Particles from gas-saturated solutions 80 - 300 fine particles and powders from various products and of designed properties... 

Model and analyze single molecules or collections, gathering data through property-driven interface in which you designate properties and CAChe chooses the best calculation method... 

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