Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Cationized gelatin

Cationized gelatin nanopar- ticle None Pol-III HI Intraureteral Obstructive C57BL/6 nephropa- mice thy Kidney TGF-p Reduction in collagen content and fibrotic tissue in the kidney interstitium (64, 81)... [Pg.21]

Cationized gelatin micropar- ticles None Pol-III U6 Intratumoral NRS-1 squamous cell carcinoma C3H/He mice Subcutaneous VEGF Suppression of tumor growth, prolonged knockdown, and decreased tumor microvascularity as compared to controls (65)... [Pg.21]

Gelatin, which is a simply denatured collagen, has shown promise in vitro and in vivo as an shRNA delivery vehicle. Cationized gelatin nanoparticles are relatively simple to produce when compared to synthetic polymers (61). They have been shown to have an in vitro transfection efficiency of approximately one order of magnitude less than PEI, but show approximately four-fold less cytotoxicity (62,63). [Pg.22]

Cationized gelatin has been used in vivo to mediate vector-based RNAi in a murine model of obstructive nephropathy after intraureteral delivery. Administration of a plasmid encoding siRNA against the transforming growth factor-(3 (TGF-P) receptor gene resulted in a reduction in collagen content and fibrotic... [Pg.22]

Kushibiki, T., Nagata-Nakajima, N., Sugai, M., Shimizu, A., and Tabata, Y. (2006) Enhanced anti-fibrotic activity of plasmid DNA expressing small interference RNA for TGF-beta type II receptor for a mouse model of obstructive nephropathy by cationized gelatin prepared from different amine compounds. Journal of Controlled Release 110 610-617. [Pg.29]

Fukunaka Y, Iwanaga K, Morimoto K, Kakemi M, Tabata Y, Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation. J... [Pg.258]

Chitosan and cyclodextrins are mainly used as natural polymers for gene delivery to the brain. In 2007, Thakor et al. used cationized gelatin to... [Pg.469]

Cationic gelatin Protein with 18 non-uniformly distributed amino acids Drug delivery 13-16... [Pg.481]

Kushibiki T, Tabata Y. Preparation of poly(ethylene glycol) induced cationized gelatin as a non-vial gene carrier. J Biomater Sci Polym Ed 2005 16 1447-61. [Pg.158]

Also related to small drug-loaded PEC particles are the studies of Bohidar et al. [139] on the entrapment of salbutamol (a bronchodilator) in PEC coacervate particles (> 400 nm) prepared by mixing anionic and cationic gelatin in the presence of the dmg. They claim that salbutamol release from the coacervate phase could not be described by known release models because too many factors prevail, e.g., dissolution, permeation of solvent into the matrix, and non-Fickian drug diffusion in a crowded environment. [Pg.239]

Kasper FK, Jerkins E, Tanahashi K, Barry MA, Tabata Y, Mikos AG. Characterization of DNA release from composites of oligo(poly(ethylene glycol) fumarate) and cationized gelatin microspheres in vitro. J Biomed Mater Res A 2006 78(4) 823—35. [Pg.255]

Tseng CL, et al. Cationic gelatin nanoparticles for dmg delivery to the ocular surface in vitro and in vivo evaluation. J Nanomater 2013 2013. [Pg.517]

Zorzi GK, et al. Expression of MUC5AC in ocular surface epithelial cells using cationized gelatin nanoparticles. Mol Pharm 2011 8(5) 1783—8. [Pg.518]

Zorzi GK, et al. Hybrid nanoparticle design based on cationized gelatin and the polyanions dextran sulfate and chondroitin sulfate for ocular gene therapy. Macromol Biosci 2011 11(7) 905-13. [Pg.518]

Hori K, et al. Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances comeal epithelial wound healing. J Control Release 2007 18(2) 169-76. [Pg.518]

Kushibiki, T. and Y. Tabata. 2005. Preparation of polyfethylene glycol)-introduced cationized gelatin as a non-viral gene carrier./Bioiwflter Sci PoZymEd 16(11) 1447-61. [Pg.213]

Solo Hill FI02 Crosslinked polystyrene modified with cationic gelatin Poor None... [Pg.198]

Nanostructures containing cationized gelatin are able to protect pDNA and siRNA from nuclease degradation and transfect a variety of cell types and tissues, both in vitro and in vivo. After cationization with ethylenediamine or spermine, the levels of transfection efficiency achieved can be compared to those provided by classic transfection agents such as polyethyleneimine. Table 8.2 shows the most important results obtained with nanoparticles based on cationized gelatin for gene delivery. [Pg.252]

ED pDNA Ability of cationized gelatin to form ncuiopcuticles by ionic gelation [112]... [Pg.253]

See other pages where Cationized gelatin is mentioned: [Pg.162]    [Pg.23]    [Pg.270]    [Pg.229]    [Pg.592]    [Pg.162]    [Pg.444]    [Pg.3]    [Pg.944]    [Pg.244]    [Pg.250]    [Pg.2]    [Pg.236]    [Pg.414]    [Pg.442]    [Pg.389]    [Pg.146]    [Pg.164]    [Pg.184]    [Pg.284]    [Pg.285]    [Pg.259]    [Pg.292]    [Pg.293]    [Pg.131]    [Pg.204]    [Pg.252]    [Pg.256]   
See also in sourсe #XX -- [ Pg.252 , Pg.256 ]



SEARCH



© 2024 chempedia.info