Rationale for study

Determining the underlying rationale for studying a neuroreceptor system, e.g. the dopamine hypothesis for cocaine abuse and schizophrenia ... 

The Rationale for Studying Tumor Cell Migration and Invasion... 

Neuropeptide Y (NPY) is a highly conserved 36 amino acid peptide of the pancreatic polypeptide family that is widely distributed throughout the mammalian brain. Y1 and Y2 receptors represent the major subtypes expressed in brain areas known to be activated upon anxiogenic stimulation, thus providing the rationale for studying the involvement of NPY and its receptor subtypes in anxiety-related behaviour (Kask et al. 2002). Other receptor subtypes in... 

Attention-deficit hyperactivity disorder has been treated with TCAs since the 1960s. The initial rationale for studies in this area rose from two separate medication needs (1) medications with longer effective half-lives (before the introduction of extended-release stim-... 

The rationale for studies on flavin semiquinone metal interactions stems from the presence of flavin coenzymes which participate in electron transfer in a number of metalloflavoproteins. Iron-containing redox centers such as the heme and nonheme iron sulfur prosthetic groups (Fe2/S2, Fe+ZS, or the rubredoxin-type of iron center) constitute the more common type of metal donor-acceptor found in metalloflavoproteins, although molybdenum is encountered in the molybdenum hydroxylases (e.g. xanthine oxidase, aldehyde dehydrogenase). 

The rationale for studying the induction of dominant cataract mutations in mice is the same as that for dominant skeletal mutations. The test108 221 uses a breeding-test method. Cataracts are observed in dilated eyes with a slit lamp. The observation time for each mouse is much... 

An additional example for a cocrystal of N,N -bis(para-Br-phenyl)melamine 2-Vin and barbital 2-IX Zerkowski et al. (1997). There are clearly a number of potentially different hydrogen-bonding donor and acceptor sites on each molecule (in fact that was part of the rationale for studying these cocrystalline materials). The two polymorphic stmctures have identical tape hydrogen-bonding patterns, but the tertiary structure, as defined by the arrangement of the tapes within the crystal is quite different (Fig. 2.22). 

The impacts of toxicants upon the structure of communities has been investigated using the resource competition models of Ulman. Species diversity may be decreased or increased and a rationale for studying indirect effects emerges. 

Properties of Plutonium. As nuclear power utilization with its associated reprocessing and waste disposal operations expands, the fate of any released plutonium assumes greater importance. However, there is another rationale for studying the environmental behavior of plutonium. Because of its solution chemistry, it is an element with rather unique qualities as a probe of environmental properties. 

Finally, the smaller the differences in proton affinity of the various groups in the uptake (release) pathway, the greater the efficiency of the pump. This requirement underlines the relevance of passive proton relay, as found in water-filled channels such as gramicidin, and provides a rationale for studying such relatively simple systems in order to better understand proton-relay in proton pumps. 

Part I (Chapters 1 through 3) represents a general introduction to the control aspects of a chemical process. An attempt is made to define what we mean by process control, to identify the needs and incentives for process control, to analyze the design questions and formulate the problems that must be solved, and to provide the rationale for studying the material that follows in the subsequent chapters. 

To provide the rationale for studying the material that follows in subsequent chapters... 

Rich ABD L. D. Mobsb, Rationale for Studies of Consumer Food Preferences. 385... 

There is a rationale for studying these redox systems, one that originates largely from the work of McCreery and coworkers in recent years with glassy carbon electrodes [139-143]. Redox reactions are generally of two types. One type includes electrode reactions that proceed by simple diffusion of the analyte to the interfadal reaction zone with the electrode serving solely as a source or sink for electrons. In this case, the electrode reaction kinetics are relatively insensitive to factors such as the surface chemistry and microstructure, but very sensitive to the density of electronic states at the formal potential (so-called outer-sphere reaction). The other pathway includes reactions that occur via some specific... 

The apparent rationale for study of the metallocene dihalides was that the cis geometry, Figure 6.4, was reminiscent of that of cisplatin, with a c chloride separation of 3.470 A for Ti, for example, in contrast to that in cisplatin, 3.349 A [102]. However, it is clear from studies of the hydrolysis of the cyclopentadienyl complexes that the aqueous chemistry is very different from that of platinum and no structural analogies should be drawn. In general, the complexes inhibit Ehrlich ascites tumours and solid growths of this tumour, are active in Lewis Lung, but are only very... 

There exist, broadly, the following three main rationales for studying and performing reactions in near-critical and supercritical fluids. 

The objective of this section is to introduce some of the broad characteristics and properties of lanthanides in seawater along with the rationale for studying the lanthanide composition of natural waters. The themes developed below will be expanded upon in subsequent sections. 

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