Fibrosis pulmonary interstitial

Pulmonary Interstitial fibrosis, pulmonary nodules, pleuritis, pleural effusions... 

Landas SK, Schwartz DA Mica-associated pulmonary interstitial fibrosis. Am Rev Respir Dis 144 718-721, 1991... 

Nitrofurantoin can cause nausea and vomiting, fever, rash, hypersensitivity pneumonitis. When given for long periods of time, nitrofurantoin can cause progressive pulmonary interstitial fibrosis. 

Interstitial A term used as an adjective relating to spaces within a tissue or organ. Pulmonary interstitial fibrosis refers to fibrosis (scarring) occurring within lung tissue. 

Parenchyma The functional cells or tissue of a gland or organ for example, the lung parenchyma. The major lung parenchymal abnormality associated with exposure to asbestos is the development of scar-like tissue referred to as pulmonary interstitial fibrosis or asbestosis. 

Pulmonary interstitial fibrosis Scar-like tissue that develops in the lung parenchymal tissue in response to inhalation of dusts of certain types of substances such as asbestos. 

Pulmonary interstitial fibrosis associated with deposition of collagen, progressive lung stiffening and impaired gas exchange, disability, and death occurred in many asbestos workers. 

Lykke AW, Stewart BW. 1978. Fibrosing alveolitis (pulmonary interstitial fibrosis) evoked by experimental inhalation of gasoline vapours. Experientia 34 498. 

Dawson A, Gibbs AR, Anderson G. An unusual perilocular pattern of pulmonary interstitial fibrosis associated with Crohn s disease. Histopathology 1993 23 ... 

Eschun, GM, Mink, SN, Sharma S. Pulmonary interstitial fibrosis as a presenting manifestation in perinuclear antineutrophilic cytoplasmic antibody microscopic... 

A number of studies of the toxicity of zinc oxide/hexachloroethane smoke have been conducted (Brown et al. 1990 Karlsson et al. 1986 Marrs et al. 1983). These studies demonstrate that smoke exposure results in pulmonary inflammation and irritation. When male Porton Wistar rats were exposed to hexachloroethane/zinc oxide smoke for 60 minutes, the lungs showed pulmonary edema, alveolitis, and areas of macrophage infiltration 3 days later. At 14 days, there was interstitial fibrosis and macrophage infiltration. At 28 days, increased fibrosis and macrophage infiltration were noted. However, these same symptoms occurred when the animals inhaled zinc chloride there was no apparent synergism between the zinc chloride and residual hexachloroethane (Brown et al. 1990 Richard et al. 1989). This is consistent with the fact that smoke contains little hexachloroethane and the observation that acute exposure to 260 ppm hexachloroethane had no effects on the lungs of rats (Weeks et al. 1979). 

Miller A, Lilis R, Godbold J. 1992. Relationship of pulmonary function to radiographic interstitial fibrosis in 2,611 long-term asbestos insulators An assessment of the International Labour Office profusion score. Am Rev Respir Dis 145(2) 263-270. 

The manufacturers have on record in the USA several pulmonary adverse effects during isotretinoin therapy, including worsening of asthma (SEDA-21,162), recurrent pneumothorax, pleural effusion, interstitial fibrosis, pulmonary granuloma, and deterioration in lung function tests. Exercise-induced asthma (35) may be caused by a significant reduction in the forced expiratory flow rate (36) and a drying effect of isotretinoin on the mucous membranes of the respiratory tract (37). 

Chronic therapy with amiodarone has been associated with pulmonary interstitial pneumonitis/alveolitis, hypersensitivity pneumonitis, and pulmonary fibrosis fatalities have resulted. Other side effects include elevated liver function tests, worsening of arrhythmias, onset of new arrhythmias, fatigue, tremor, involuntary movements, dizziness, paresthesias, difficulty in walking, hypothyroidism, hyperthyroidism, nausea, vomiting, constipation, anorexia, corneal... 

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