Pseudotumor cerebri

Silent" brain lesions on magnetic resonance imaging are associated with poor cognitive and fine motor functions pseudotumor cerebri (case report)... 

Sanborn GE, Selhorst JB, Calabrese VP, et al. 1979. Pseudotumor cerebri and insecticide intoxication. Neurology 29 1222-1227. 

Ocular complications following local or systemic administration of steroids include glaucoma, cataracts, adverse influence on specific ocular infections, pseudotumor cerebri, ptosis, mydriasis, subjective visual complaints, visual field defects, systemic absorption of the topical medication, conjunctival and palpebral petechiae, epithelial punctate keratitis, and, possibly, corneal and scleromalacia. ... 

Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea, and vomiting, and visual disturbances. Screen patients with these symptoms for papilledema and, if present, advise the patients to discontinue danazol immediately and refer them to a neurologist for further diagnosis and care. 

Intracranial hypertension Danazol has been associated with several cases of benign intracranial hypertension (also known as pseudotumor cerebri) (see Black Box Warning). 

Children - Pseudotumor cerebri slipped capital femoral epiphysis craniosynostosis premature closure of the epiphyses. 

Pseudotumor cerebri Pseudotumor cerebri (benign intracranial hypertension) in adults has been associated with tetracycline use. 

CA/S-Bulging fontanel, convulsions, dizziness, headache, hypesthesia, paresthesia, pseudotumor cerebri, sedation, vertigo. 

Tetracyciine ciass antibiotics Glycylcycline class antibiotics are structurally similar to tetracycline class antibiotics and may have similar adverse effects. Such effects may include photosensitivity, pseudotumor cerebri, pancreatitis, and antianabolic action (which has led to increased serum urea nitrogen [BUN], azotemia, acidosis, and hypophosphatemia). 

Cardiovascular - Benign intracranial hypertension (pseudotumor cerebri) has been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely. Changes in electrocardiogram (eg, nonspecific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions. 

CNS- Fatigue headache pseudotumor cerebri, including headache, visual disturbances, and papilledema dizziness drowsiness insomnia lethargy malaise nervousness paresthesias seizures stroke syncope weakness suicidal ideation suicide attempts suicide psychosis emotional instability aggression violent behaviors. Depression has occurred and has subsided with discontinuation of therapy and recurred upon reinstitution. 

Headache, which rarely may be attributable to pseudotumor cerebri. 

Pseudotumor cerebri is another potential complication of chronic use of these agents, particularly in individuals treated for severe cystic acne with simultaneous use of isotretinoin. This complication can be induced within several days of initiation of therapy and usually resolves with cessation of treatment. 

Benign intracranial hypertension (pseudotumor cerebri) occurs rarely. 

Adrenoicorticai insufficiency, increased intracraniai pressure, pseudotumor cerebri, impaired wound heaiing, Cushing s syndrome, HPA suppression, skin uicers, toier-ance, withdrawai, visuai impairment, ocuiar hypertension, cataracts... 

Weight gain, bradycardia or tachycardia, acne, rash, muscle twitching, cold and cyanotic extremities, pseudotumor cerebri (eye pain, headache, tinnitus, vision disturbances)... 

Glucocorticoids have important effects on the nervous system. Adrenal insufficiency causes marked slowing of the alpha rhythm of the electroencephalogram and is associated with depression. Increased amounts of glucocorticoids often produce behavioral disturbances in humans initially insomnia and euphoria and subsequently depression. Large doses of glucocorticoids may increase intracranial pressure (pseudotumor cerebri). 

Most patients with cystic acne respond to 1-2 mg/kg, given in two divided doses daily for 4-5 months. If severe cystic acne persists following this initial treatment, after a period of 2 months, a second course of therapy may be initiated. Common adverse effects resemble hypervitaminosis A and include dryness and itching of the skin and mucous membranes. Less common side effects are headache, corneal opacities, pseudotumor cerebri, inflammatory bowel disease, anorexia, alopecia, and muscle and joint pains. These effects are all reversible on discontinuance of therapy. Skeletal hyperostosis has been observed in patients receiving isotretinoin with premature closure of epiphyses noted in children... 

Uses Broad-spectrum antibiotic Action Bacteriostatic protein synth Spectrum Gram(+) Staphylococcus sp, Streptococcus sp Gram(-) H. pylori Atypicals Chlamydia sp, Rickettsia sp, Mycoplasma sp Dose Adults. 250-500 mg PO bid—qid Peds > 8 y. 25-50 mg/kg/24 h PO q6-12h i w/ renal/hepatic impair, w/o food preferred Caution [D, +] Contra PRG, antacids, w/ dairy products, children <8 y Disp Caps 100, 250, 500 mg tabs 250, 500 mg PO susp 250 mg/5 mL SE Photosens, GI upset, renal failure, pseudotumor cerebri, hepatic impair Interactions T Effects OF anticoagulants, cligoxin effects W/ antacids, cimeticline, laxatives, penicillin, Fe supl, dairy products effects OF OCPs EMS T Effects of anticoagulants monitor for signs of electrolyte disturbances and hypovolemia d/t D ... 

Long-term glucocorticoid treatment can result in papilledema and increased intracranial pressure (the syndrome of pseudotumor cerebri or so-called benign intracranial hypertension ), particularly in children. 

Insomnia, psychic stimulation, general nervousness, and tremor are among the hyperthyroid symptoms that result from relative overdosage. Pseudotumor cerebri has incidentally been observed shortly after levothyroxine was... 

Van Dop C, Conte FA, Koch TK, Clark SJ, Wilson-Davis SL, Grumbach MM. Pseudotumor cerebri associated with initiation of levothyroxine therapy for juvenile hypothyroidism. N Engl J Med 1983 308(18) 1076-80. 

Headache is a common adverse effect of somatropin. It often occurs early in treatment and usually responds to temporary dosage reduction followed by gradual re-esca-lation (1,24). It can be an early indicator of the rare complication pseudotumor cerebri (idiopathic intracranial hypertension), particularly in high-risk groups, such... 

According to the authors there have been 40 cases of pseudotumor cerebri associated with somatropin therapy worldwide, owing to stimulation of cerebrospinal fluid production or reduced drainage. 

Isensee C, Reul J, Kentrup H, Thron A (1992a) Entziindliche Sinusstenose als Ursache eines Pseudotumor cerebri beim Kind. Angiographie- und MRT-Befunde. Klin Neuroradiol 2 199-202... 

Wessel K, Thron A, Linden D, Petersen D, Dichgans J (1987) Pseudotumor cerebri clinical and neuroradiological findings. Eur Arch Psychiatr Neurol Sci 237 54-60... 

Pseudotumor cerebri Benign intracranial hypertension characterized by headache and blurred vision may occur in adults. Though discontinuation of the drug reverses the condition, it is not clear whether permanent sequelae may occur. 

Pseudotumor cerebri (benign intracranial hypertension) has been linked to lithium in over 30 cases, with headache, papilledema, increased intracranial pressure, reduced vision, and a risk of blindness (201). The condition tends to improve on withdrawal, but surgical intervention may sometimes be necessary. A review of pseudotumor cerebri devoted one paragraph to induction of this condition by lithium and provided six references but no new information (202). 

A 17-year-old woman developed pseudotumor cerebri with headache after she had taken lithium for 6.5 weeks (203). Papilledema and increased intracranial pressure resolved fully when lithium was withdrawn, and she was given acetazolamide. 

Other effects on the visual system attributed to lithium include reduced accommodation, exophthalmos, extraocular muscle abnormalities, nystagmus (most characteristically downbeat), oscillopsia, photophobia, and papilledema with visual impairment (pseudotumor cerebri) (201). 

The co-administration of lithium and minocycline in an adolescent was associated with pseudotumor cerebri (659), although minocycline can do this on its own (SED-15, 2349). 

Jonnalagadda J, Saito E, Kafantaris V. Lithium, minocycline, and pseudotumor cerebri. J Am Acad Child Adolesc Psychiatry 2005 44 209. 

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