T wave changes

Electrocardiogram (ECG) May be normal or could show numerous abnormalities including acute ST-T-wave changes from myocardial ischemia, atrial fibrillation, bradycardia, and LV hypertrophy. 

Measurement of QT interval Definition of the end of the T wave. Changes in T wave morphology and occurrence of U waves (these may be important warning signs and precede the occurrence of TdP) Errors in manual measurement in QT interval Variability in the heart rate (need to correct the QT value for heart rate) Lack of reliable correlation between readings from Holter recordings and standard ECG Lack of standardization of automated ECG readings (computerized methods are often unreliable) Need for a central core laboratory to analyze data... 

Adverse reactions may include Stevens-Johnson syndrome pericardial effusion T-wave changes rebound hypertension (following gradual withdrawal in children) decreased initial hematocrit, hemoglobin and erythrocyte counts nausea vomiting temporary edema alkaline phosphatase/serum creatinine/BUN increase, hypertrichosis. 

Rare, transient, nonspecific T-wave changes have been reported on EGG in patients taking molindone. 

Cardiovascular - Benign intracranial hypertension (pseudotumor cerebri) has been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely. Changes in electrocardiogram (eg, nonspecific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions. 

Mannitol (OsmitroL others) [Osmotic Diuretic] Uses Cerebral edema, T lOP/ICP, renal impair, poisonings Action Osmotic diuretic Dose Test dose 0.2 g/kg/dose IV over 3-5 min if no diuresis w/in 2 h, D/C Oliguria 50-100 g IV over 90 min T lOP 0.5-2 g/kg IV over 30 min Cerebral edema 0.25-1.5 g/kg/dose IV >30 min Caution [C, ] w/ CHF or volume overload Contra Anuria, dehydration, HE, PE Disp Inj SE May exacerbate CHF, N/V/D Interactions t Effects OF cardiac glycosides X effects OF barbiturates, imipramine, Li, salicylates EMS Monitor ECG for hypo-/hyperkalemia (T wave changes) OD May cause dehydration, t urine frequency/amount hypotension and CV collapse symptomatic and supportive... 

PO T- wave changes (usually revert to pretreatment state with continued therapy or drug withdrawal)... 

Teeth enamel erosion and Vomiting Q-T and T-wave changes Hypokalemia, cardio-... 

Lithium Neurological tremor, ataxia, seizures Endocrine hypothyroidism Cardiovascular T wave changes, sinus node dysfunction Renal polyuria, nephrogenic diabetic insipidus Dermatological hair loss, acne, psoriasis, rash Gastrointestinal nausea, diarrhea Miscellaneous fluid retention, weight gain, weakness... 

In rabbits burned by an unknown amount of white phosphorus, electrocardiogram alterations (prolongation of QT interval, ST segment depression, T-wave changes, bradycardia, and low voltage QRS complex) indicative of myocardial damage were observed however, no histological alterations were observed in the heart (Bowen et al. 1971). 

A 13-year-old boy taking lithium developed a pseudo-myocardial infarct pattern on the electrocardiogram this may have been an overinterpretation of nonspecific T-wave changes (118). 

Two types of T wave changes have also been described after treatment with thioridazine type I (with rounded, flat, or notched T waves) and type II (with biphasic T waves) (5). 

Cardiac dysrhjdhmias have been reported after amsacrine therapy in association with hypokalemia. Pre-existing supraventricular dysrhjdhmias or ventricular extra beats are not absolute contraindications to its use (49). Of 5430 patients treated with amsacrine, 65 developed cardiotoxicity, including prolongation of the QT interval, non-specific ST-T wave changes, ventricular tachycardia, and ventricular fibrillation (50). There were serious ventricular dysrhythmias resulting in cardiopulmonary arrest in 31 patients 14 died as a result. The dysrhjdhmias occurred within minutes to several hours after drug administration. The cardiotoxicity was not related to total cumulative dose, and hypokalemia was possibly a risk factor for dysrhythmias. 

There has been a report of T wave changes on the electrocardiogram during caudal administration of local anesthetics (6). 

Previous reports have suggested that an increase in T wave amplitude could result from inadvertent intravascular administration of adrenaline-containing local anesthetics. This is the first case report of local anesthetics alone causing significant T wave changes. 

Minor electrocardiographic abnormalities, especially T wave changes, are common but are probably of no functional significance of patients (1). Dysrhythmias with prolongation of the QT interval occur in a small minority of patients (2). 

Heart Proionged QT intervai ST and T wave changes Myocarditis... 

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