Propionic acid, 3-Hydroxy-2-phenyl

In a similar manner the other amino acids react tyrosine, j3-p-hydroxy-phenyl-a-amino-butyric acid yielding p-hydroxy-phenyl-ethyl alcohol, tyrosol while phenyl-alanine, a-amino-j8-phenyl-propionic acid, yields phenyl-ethyl alcohol. Succinic acid, for example, which is of usual occurrence in fermented liquors is probably formed by a similar reaction from glutamic acid with the additional step of oxidation in the process. 

In 1909, Thiele and Landers reported the synthesis of p- (3-methoxy-isoxazol-5-yl)-propionic acid (77), from the corresponding chloride or bromide (76). In 1961, a similar reaction was reported for 3-chloro-5-arylisoxazoles, enabling the synthesis of 3-hydroxy-5-phenyl-... 

The pure dimethylaminoethanol salt was dissolved in 400 ml of 50% acetic acid at 90°C and then cooled to 5°C. The solid which precipitated was collected by filtration, washed with water, cold 50% acetic acid and finally with low-boiling petroleum ether. After drying in vacuo there was obtained 24 g of hydrated dextro-/3-(3,5-diiodo-4-hydroxy)-a-phenyl-propionic acid, MP 80° to 85°C. 

C25H27CIO3 /O/Oy-i -J) see Trenbolone acetate ( )-2-chioro-3-[4-[(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)incthoxy]phenyl]propionic acid (C23H27C10 97322-69-5) sec Troglitazone 4 -chloro-2 (24midazoUn-2-yl)benzophenone (Ci HjiClNjO 22590-J7-6) see Mazindo ... 

More recently, some AMPA agonists showing unusual stereostructure-activity have been compared using the commercial docking package Glide (21). These include the enantiomers of 2-amino-3-(3-hydroxy-l,2,5-thiadiazol-4-yl)propionic acid (TDPA) and 2-amino-3-hydroxy-5-phenyl-4-isoxazolyl propionic acid (APPA) (28), as well as 3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid (5-HPCA). 

Nate Abbreviations I, U -tiis(hydroxy-phenyl)ethane (THPE), 2,2-bis(dimeihylol)propionic acid (bis-MPA). 

Fig. 7. Effect of modifying pH on EDA of MRNi (O) (S)-manderic acid MRNi (33) ( ) (S)-2-hydroxy-3-phenyl-propionic acid-MRNi (33) ( ) (S)-aspartic acid-MRNi (19) (A) (R.R),tartaric acid-MRNi (25). Modifying conditions 0°C. Reaction conditions MAA (neat), 60 C, 80-100 kg/cm2.

The alkaloids of this group are derived from a combination of a piperidine and a pyrrolidine ring, designated as tropane (Figure 14.2). The 3-hydroxy derivative of tropane is known as tropine and is the basic component of atropine. When atropine is hydrolyzed, it forms tropine and tropic acid (a-phenyl-p-hydroxy-propionic acid). Atropine is the tropic acid ester of tropine. It has been prepared synthetically. Tropic acid contains an asymmetric carbon atom. The racemic compound (atropine) as obtained naturally or as synthesized may be resolved into its optically active components, d- and /-hyoscyamine. Atropine is racemic hyoscyamine that is, it consists of equal parts of /-hyscyamine and plant cells and also in the process of extraction, so that the relative proportion of the isomers in the plants and in the preparations varies. However, atropine itself does exist in small amounts in the plants, although most of it is formed from the /-hyoscyamine in the process of extraction. 

Methylester 3-(3,5-di-tert.-butyl-4-hydroxy-phenyl) propionic acid 292.2 0.918 48.0... 

Disposition in the Body. Readily and almost completely absorbed after oral administration. More than 60% of a dose is excreted in the urine in 24 hours, including about 9% of the dose as the 2-hydroxy metabolite, 2-[4-(2-hydroxy-2-methylpropyl)phenyl]-propionic acid, about 17% as the conjugated hydroxy metabolite, about 16% as the 2-carboxy metabolite, 2-[4-(carboxypro-pyOphenyljpropionic acid, and about 19% as the conjugated carboxy metabolite (both metabolites are inactive) less than 10% of a dose is excreted unchanged. The remainder of the dose is probably eliminated in the faeces after excretion in the bile excretion is virtually complete within 24 hours. 

AO containing various phenolic moieties were prepared by transesterification in the presence of tetraalkyl titanates. Randomly distributed -active moieties are characteristic of 140 (only the hard polyester segment is given) prepared from dimethyl terephthalate, 1,4-butanediol, poly(tetramethylene oxide)diol and dimethyl 5-(3,5-di-tm-butyl-4-hydroxybenzenepropaneamido)isophthalate [181]. The mentioned polymeric AO was used for stabilization of polyether-polyester elastomers. A partial attachement of tetrakis[methylene 3(3,5-di-tert-butyl-4-hydroxy-phenyl)propionate]methane (3) via transesterification reaction was expected in the synthesis of another polyether-polyester elastomer by [182]. A reversible redox polyester was formed from 2,5-bis(2-hydroxyethyl)hydroquinone and dichlorides of aliphatic dicarboxylic acids [137],... 

C13H11N03 phenyl 4-amino-3-hydroxybenzoate 133-11-9 25.00 1.2508 2 25879 C13H13N05 3-(4-hydroxyphenyl)propionic acid N-hydroxys 34071-95-9 25.00 1.2936 2... 

The side-chain carboxy acids which we have studied are phenyl acetic, phenyl propionic or hydrocinnamic, phenyl acrylic or cinnamic and phenyl propiolic. Phenol derivatives of all of these are known. Hydroxy phenyl acetic acid is not important. 

Tyrosine.— para-Hydroxy-phenyl propionic acid has a side-chain amino derivative which is one of the amino acid cleavage products obtained by hydrolyzing proteins. It is known as tyrosine. 

Polyethylene Organic and water extracts HPTLC. Plate = 10 x 10 cm Fertigplatten Kiselgel 40. Mobile phase chloroform/cyclohexane (12 1). Densitometric detection. Eganox 1076 3,5-di-fert-butyl-4-hydroxy-phenyl propionic acid 35... 

Low-temperature reaction of diethyl 1-oxopropylphosphonate with LiHMDS affords exclusively the (Z)-enolate, which, on condensation with benzaldehyde in excess (2.2 eq), gives a highly diastereoselective reaction leading to the formation of syn- and anZz-3-hydroxy-2-methyl-3-phenyl-propionic acids in a 97% yield, together with diethyl 1-hydroxy benzyl phosphonate. 

Hostanox 03 Bis-(3,3-bis-(4 -hydroxy-3 -rerr-butylphenyl) butanoic acid)-glycol ester Hostanox OlO Pentaerythryl-tetrakis 3-(3,5-di-rerr-butyl-4-hydroxy-phenyl)propionate HPLC High-performance liquid chromatography... 

Droxidopa. threo-, 3-Diltydroxy-l.-tvrositte i-threo-3-(3,4-dihydroxyphenyl)serine ( — )-(2, 3R)-2-aimnO-3-hydroxy-3-(3,4-dihydroxy phenyl)propionic acid threo-dopaserine L-iJirw-DOPS l-DOPS SM-5688 Dops. C,HnNO. mol wt 2 3. 9. C 50.71%, H 5.20%, N 6.57%, O 37 52%. Synthetic amino acid precursor of norepinephrine, q.v. Prepn of racemate K. W. Rosenmund, H. Dornsaft,... 

Suh et al.65 have reported a formal total synthesis of Mansonone F and this is described in Scheme 12. 5-Methoxy-a-tetralone (127) was converted to 1-methyl-5-hydroxy-naphthalene (128) by the standard organic reactions. Treatment of (128) with phenyl boronic acid, paraformaldehyde and propionic acid followed by catalytic hydrogenation yielded compound (129). This on alkylation gave the compound (130) which on alkaline hydrolysis was converted to acid. The acid halide underwent intramolecular Friedal-Crafts acylation affording an intermediate (131) whose transformation to Mansonone F has been accomplished by Best and Wege.59... 

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