Hydroxyphenyl propionic acid

The antioxidative activities of polymeric antioxidants prepared from Verona oil and the conventional phenolic antioxidant 3-(3,5-di-terf-butyl-4-hydroxyphenyl)propionic acid (DTBH), chemically grafted to polystyrene and polyurethanes, is similar and in some cases even better than that of the corresponding low-MW phenolic antioxidants [81]. 

In a related series of experiments, the amino group and/or the carboxylic acid group of tyrosine were replaced by hydrogen atoms. The corresponding tyrosine derivatives are 3-(4 -hydroxyphenyl)-propionic acid, commonly known as desaminotyrosine (Dat), and tyramine (Tym) (structures 3-5). 

Coumarin (7.88) is a well-known 6-lactone (six-membered ring) of natural origin found in various preparations such as some tobaccos, alcoholic beverages, and cosmetics. Besides reactions of oxidation, reduction, and conjugation, coumarin is also subject to lactone hydration in vivo and in the presence of microsomes [170-174], The resulting metabolites include ortho-coumaric acid (7.89) formed directly from coumarin, 3-(2-hydroxyphenyl)-propionic acid (7.91) formed following reduction of coumarin to dihydrocou-... 

Aryl esters of 4-hydroxyhutyric acid, 5-hydroxyvaleric acid, 2-hydroxyphenylacetic acid, and 3-(2-hydroxyphenyl)propionic acid lactonize with rate constants proportional to (Capon et... 

The phenols (no. 30a, 30b, 32) are used as reactants to synthesize several of the company s products, including the benzotriazoles. The 2-chloro-4,6-bls-isopropylam-ino-s-triazine (no. 13) are herbicides the chloro compound is used to control weeds and grass in corn and in milo, and the methoxy compound is used for general plant control. Several esters of 3-(3 ,5 -di-t-butyl-4 -hydroxyphenyl) propionic acid were identified, the most abundant being the octadecyl and methyl esters. 

All applications with the exception of the two marked with a UV detection were obtained using MS detection. (5)-2-((2-Benzoylphenyl)amino)-3-(4-hydroxyphenyl)-propionic acid. 

Tea is known to be a good sonrce of phenolic substances and its earliest HPLC characterization was pnblished in 1976 [359] The introdnction of DAD as a detection technique for HPLC greatly improved the possibility of fully characterizing it. In 2004, Yao et al. [360] published a study on tea cnltivated in Anstralia six phenolic acids were identified, including p-coumarylquinic, p-coumaric, and 3-(p-hydroxyphenyl) propionic acid. Previously, Bonoli et al. [361] carried out a comparison of HPLC with capillary electrophoresys and concluded that the latter shows advantages in terms of the time of analysis with respect to HPLC, even if in 2004, Pelillo et al. [362] were able to develop a fast analysis by means of HPLC. 

The homolog of 106a, 3-(4-hydroxyphenyl)propionic acid (106b), undergoes a similar oxidation by H2O2 to a fluorescent dimer (107b, = 305 nm, 7.3 = 405 nm), catalyzed... 

Hydroxyphenyl)propionic acid, hydrogen peroxide determination, 639 6-Hydroxy-l,2,4-trioxanes, synthesis, 288 Hypercholesterolemia, reactive oxygen species in blood, 612... 

A flask containing 3-(4-hydroxyphenyl) propionic acid was treated with chloroiodide and the product isolated. 

Benzotriazol-2-yl)-3-ferf-butyl-4-hydroxyphenyl]-propionic acid... 

Fmoc-amino acids used as building blocks of testing compounds are as follows Fmoc-Asp(OtBu)-OH, Fmoc-Cys(Trt)-OH, Fmoc-Asn(Trt)-OH, Fmoc-Gln(Trt)-OH, Fmoc-Met-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Lys (Boc)-OH, Fmoc-Ile-OH, Fmoc-His(Trt)-OH, Fmoc-Tyr(tBu)-OH, Fmoc-Arg(Pmc)-OH, Fmoc-Phe-OH, Fmoc-Ser(tBu)-OH, Fmoc-Thr(tBu)-OH, Fmoc-Val-OH, Fmoc-Pro-OH, Fmoc-Trp(Boc)-OH, Fmoc-D-Ala-OH, Fmoc-D-Arg(Pmc)-OH, Fmoc-D-Trp(Boc)-OH, Fmoc-D-Cys(Trt)-OH, Fmoc-D-Asp(OtBu)-OH, Fmoc-D-Glu(OtBu)-OH, Fmoc-D-His(Trt)-OH, Fmoc-D-Gln(Trt)-OH, Fmoc-D-Leu-OH, Fmoc-D-Met-OH, Fmoc-D-Pro-OH, Fmoc-D-Ser(tBu)-OH, Fmoc-D-Lys(Boc)-OH, Fmoc-D-Tyr(tBu)-OH, Fmoc-D-Thr(tBu)-OH, Fmoc-D-Phe-OH, Fmoc-D-Asn(Trt)-OH, Fmoc-3-(4-pyridyl)alanine, Fmoc-D-3-(3-pyridyl)alanine, Fmoc-4-tert-butoxyproline, Fmoc-3-chlorophenylalanine, Fmoc-norleucine, Fmoc-2-cyclohexylglycine, Fmoc-2-aminoisobutyric acid, Fmoc-tranexamic acid, Fmoc-(i ,S)-3-amino-3-(2-furyl)propionic acid, Fmoc-(i ,S)-(6,7-di-methoxy)-l,2,3,4-tetrahydroquinoline-3-carboxylic acid, Fmoc- (R, S)-3-amino-3-(4-hydroxyphenyl)propionic acid, Fmoc-(i ,S)-3-aminovaleric acid, Fmoc-(i ,5 )-3-amino-3-(3,4-dichlorophenyl)propionic acid, Fmoc-isonipecotic acid, Fmoc-(i ,S)-3-amino-3-(3,4-methylenedioxyphenyl)... 

Phenol Resin (24). A solution of 3-(4-hydroxyphenyl)propionic acid (2.2 g, 13.3 mmole), A-ethyl-.V -dimethylaminopropylcarbodiimide (2.5 g, 13 mmol) and 1-hydroxybenzotriazole monohydrate (1.8 g, 12 mmol) in DMF (20 ml) was treated with aminomethylpolystyrene resin (1.0 g, 4.5 mmol N/g resin). The resulting reaction mixture was stirred for 36 h at room temperature. The product resin was obtained upon filtration and washings with DCM, MeOH, a solution of NH4OH MeOH (1 1), DMF, DCM, MeOH, DCM, and hexanes (2x) followed by drying under vacuum at 40°. 

Zhu et al. [103] reported a fadle access to biologically relevant macrocycles bearing an endo diaryl ether bond by means of a tandem Ugi-4CR/SNAr. The reaction between 3-hydroxyphenylacetic [or 3-(3-hydroxyphenyl)propionic] acid, aldehydes, amines, and isocyanide 197 gave the expected dipeptide derivatives 198 as a 1 1 mixture of diastereoisomers. The reaction gave high yields when performed in tri-... 

Hydroxyphenyl)propionic acid Potassium carbonate Isopropylamine... 

A solution of 17 g (0.1 mole) of 3-(4-hydroxyphenyl)propionic acid in 500 mL methanol and 2 mL concentrated sulfuric acid were placed in a Soxhlet extractor charged with 3A molecular sieves. The solution was refluxed for 72 hours and the sieve were exchanged at 24 hour intervals. The reaction medium was then evaporated to an oil which was dissolved in 100 mL toluene and extracted with 100 mL water (3 times). The toluene phase was dried over magnesium sulfate, treated with activated charcoal and evaporated to provide 15 g (80%) of a clear oil. The NMR spectrum was consistent with the methyl 3-(4-hydroxyphenyl)propionate. 

A solution of a-ethyl-m-hydroxycinnamic acid and potassium hydroxide in water was added to 3% sodium amalgam, and the mixture was stirred while heating on a steam bath for several hours. The mixture was then cooled, the mercury separated, and the reaction mixture was acidified and extracted with ether. The ether extracts were concentrated giving a residue containing a-ethyl-p-(m-hydroxyphenyl)propionic acid. 

Aryl esters of 4-hydroxybutyric acid, 5-hydroxyvaleric acid, 2-hydroxyphenylacetic acid, and 3-(2-hydroxyphenyl)propionic acid lactonize with rate constants proportional to iopH picw (Capon et al., 1973). The second-order rate constant at 30° for lactonization of phenyl 4-hydroxybutyrate is ca. 3000 times greater than kOH for hydrolysis of phenyl acetate at 25°. Lactonization of phenyl 4-hydroxybutyrate is catalysed by acetate and phosphate buffers in... 

Tyrosine, a-amino-j3-(para-hydroxyphenyl)propionic acid... 

C13H11N03 phenyl 4-amino-3-hydroxybenzoate 133-11-9 25.00 1.2508 2 25879 C13H13N05 3-(4-hydroxyphenyl)propionic acid N-hydroxys 34071-95-9 25.00 1.2936 2... 

If the antibody is immobilised on Sepharose , the supernatant containing the free, radioactive peptide can be separated easily and assayed in a gamma counter. With a standard curve drawn for known amounts of peptide subjected to assay under exactly the same conditions, unknown amounts of peptide can be determined by interpolation on the standard curve. There are two potential problems with this type of radioimmunoassay. First, the peptide to be assayed perhaps does not contain Tyr. If it contains His, however, this may suffice since His can be iodinated, especially by an enzymic procedure described below. Alternatively, the peptide is allowed to react with the Bolton and Hunter reagent (Bolton and Hunter, 1973), prepared by iodina-tion of the ester of 3-(4 -hydroxyphenyl)propionic acid and /V-hydroxysuccinimide. Any free amino group can be acylated by this reagent. Secondly, reaction of a peptide with Nal and chloramine-T can cause oxidation of Met, Cys and even Tyr residues, which can interfere with complexation of the iodinated peptide with antibodies raised to the un-iodinated peptide. An alternative method (Holohan et al., 1973) of iodination uses lactoperoxidase in the presence of H202. As pointed out above, this procedure is applicable to the iodination of His residues. This method avoids modification of the side-chains of Met, Cys and Tyr. 

Lu Y, Weltrowska G, Lemieux C et al (2001) Stereospecilic synthesis of (2S)-2-methyl-3-(2, 6 -dimethyl-4 -hydroxyphenyl)propionic acid (Mdp) and its incorporation into an opioid peptide. Bioorg Med Chem Lett 11 323-325... 

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