2- methylpropyl phenyl

Methyl-2-[4-(2-methylpropyl)phenyl]oximinoethane (/j-Isobutylphcnyl-a-mcthylacctaldchydc oxime)... 

S -3- 4-(2-Methylpropyl)phenyll-l-hutene Typical Procedure for the Vinylation of Grignard Reagents Using Phosphine Ligands ... 

A 300-mL flask containing 26 mg (0.20 mmol) of anhyd nickel chloride and 63 mg (0.21 mmol) of (S)-(2-dimethylamino-3-methylbutyl)diphcnylphosphine is filled with argon after evacuation. To it are added, at — 78 C, 2.8 mL (40 mmol) of bromoethene and 131 mL (80 mmol) of l-[4-(2-methylpropyl)phenyl]ethyl-magnesium chloride (0.61 M) in diethyl ether. The mixture is stirred at 0 C for 2 d and hydrolyzed with 10% HCl. The organic layer and diethyl ether extracts from the aqueous layer are combined, washed with sat. aq NaHCO, and dried over anhyd Na2S04. After evaporation of solvent, distillation is through a short Vigreux column (70-71 rC /2 Torr) yield 6.1 g (81 %) fx](,° + 5.66 (neat). 

Related ligands for catalysis, namely BINAP ligands substituted with Frechet dendrons (5, Fig. 6.34) were prepared by Chan et al. [51]. They form rutheniu-m(II) complexes in situ, whose activity in the stereoselective hydrogenation of 2-[p-(2-methylpropyl)phenyl]acrylic acid was investigated. 

Disposition in the Body. Readily and almost completely absorbed after oral administration. More than 60% of a dose is excreted in the urine in 24 hours, including about 9% of the dose as the 2-hydroxy metabolite, 2-[4-(2-hydroxy-2-methylpropyl)phenyl]-propionic acid, about 17% as the conjugated hydroxy metabolite, about 16% as the 2-carboxy metabolite, 2-[4-(carboxypro-pyOphenyljpropionic acid, and about 19% as the conjugated carboxy metabolite (both metabolites are inactive) less than 10% of a dose is excreted unchanged. The remainder of the dose is probably eliminated in the faeces after excretion in the bile excretion is virtually complete within 24 hours. 

Recently, four generations of chiral diphosphine BI NAP-centered dendrimers were synthesized by Fan and coworkers via the condensation of Frechet-type dendrons with fR)-5,5 -diamino-BINAP (Figure 4.3) [32, 33]. The first- to third-generation BINAP dendrimers were tested in the Ru-catalyzed asymmetric hydrogenation of 2-[p-(2-methylpropyl)phenyl]-acrylic acid in methanol toluene (1 1, v/v) at room temperature (Scheme 4.2) [32]. The size of the dendrihc wedges was... 

Recycling experiments were performed using 2-[p-(2-methylpropyl)phenyl]acryl ic acid as a substrate. Upon the completion of the reaction, a small amount of water (2.5%) was added to the homogeneous reaction solution to accomplish complete phase separation. More than 99% of the second-generation catalyst was separated and extracted to the nonpolar hexane phase, whereas the polar product mainly stayed in the ethanol phase. The catalyst was reused at least four times, and showed similar reactivities and enantioselectivities on each occasion. 

Very recently, Fan et al. [13] reported on the use of a water-soluble PEO-substitut-ed first- and second-generation Frechet-type dendrimer with a chiral BINOL (1,1 -bi-2-naphthol) unit in catalysis. The enantiomeric excess in asymmetric hydrogenation of 2-[p-(2-methylpropyl)phenyl]acrylic acid with [RuCl(BINAP)(cymene)]Cl in an aqueous system was reported to increase upon addition of the dendritic... 

Trade Names. Lilestralis (AFC), Lilial (Giv.), Lysmeral (BASF), Lilialdehyde (Kuraray). 2-Methyl-3-[4-(2-methylpropyl)phenyl]propanal [6658-48-6]... 

The main metabolites of ibuprofen, the glucuronides of ibuprofen and of the side-chain hydroxylated derivative 2-[4-(2-hydroxy-2-methylpropyl)phenyl]propionic acid) and a side-chain oxidized compound 2-[4-(2-carboxy-2-methylpropyl)phenyl]-propionic acid) could be detected after SPE using a 250-MHz instrument (Figure 8-2) [10]. 

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