Production of Poly--Hydroxybutyrate-CO

Chen GQ, Zhang G, Park SJ, Lee SJ (2001) Industrial production of poly(hydroxybutyrate-co-hydroxyhexanoate). Appl Microbiol Biotechnol 57 50-55 Chen JY, Liu T, Zheng Z, Chen JC, Chen GQ (2004) PolyhydroxyaUcanoate synthases PhaCl rmd PhaC2 from Pseudomonas stutzeri 1317 had different substrate specificities. FEMS Microbiol Lett 234 231-237... 

Chen GQ, Zhang G, Park SJ, Lee SY. Industrial production of poly(hydroxybutyrate-co-hydroxyhex-anoate). Appl Microbiol Biotechnol 2001 57 50-5. 

Chen, G.Q., Zhang, G., Park, S. J., Lee S. Y., 2001, Industrial Production of Poly(hydroxybutyrate-co-hydroxyhexanoate). Appl Microbiol Biotechnol 51 50-55. 

Ramsay, B. A., K. Lomaliza, C. Chavarie, B. Dube, P. Bataille, J. A. Ramsay. 1990. Production of poly-(/ -hydroxybutyric-co-/ -hydrox5rvaleric) acids . Appl. Environ. Microbiol. 56 2093-2098. 

Procter Sc Gamble developed a wide range of poly(hydroxybutyrate-co-hydroxyalkanoates) [copolymers of P(3HB) and 3-hydroxyhexanoate, P(3HB) and 3-hydroxyoctanoate, P(3HB) and 3-hydroxyoctadecanoate] with the tradename Nodax. In 2007, Meredian Inc. purchased Procter Sc Gamble s PHA technology. Meredian Inc. has announced the start-up of production at full industrial level (30 ktonnes/year) in its Bainbridge facility in the second half of 2014 [21]. 

Construction of Recombinant Escherichia coli Strains for Production of Poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)... 

Kim, B. S., Lee, S. C.,Lee, S. Y., Chang, H. N, Chang, Y. K., and Woo, S. 1.1994b. Production of poly(3-hydroxybutyric-co-3-hydroxyvaleric acid) by fed-batch culture of Alcaligenes eutrophus with substrate control using on-line glucose analyzer. Enz. Microbial Technol., 16, 556-561. 

Deng, Y. et al. Poly(hydroxybutyrate-co-hydroxyhexanoate) promoted production of extracellular matrix of articular cartilage chondrocytes in vitro. Biomater. 2003, 24(23), 4273 281. 

Choi MH, Yoon SC, Lenz RW (1999) Production of poly(3-hydroxybutyric acid-co-4-hydroxybutyiic acid) and poly(4-hydroxybutyric acid) without subsequent degradation by Hydrogenophaga pseudoflava. Appl Environ Microbiol 65 1570-1577 Chowdhury AA (1963) Poly-/3-hydroxybuttersaure abbauende bakteiien und exo-enzyme. Arch Microbiol 47 167-200... 

Du GC, Chen J, Yu J, Lun S (2(X)la) Continuous production of poly-3-hydroxybutyrate by Ralstonia entrapAa in a two-stage culture system. J Biotechnol 88 59-65 Du GC, Chen J, Yu J, Lun S (2(X)lb) Feeding strategy of propionic acid for production of poly(3-hydroxybutyrate-co-3-hydroxyv2ilerate) with Ralstonia eutropha. Biochem Eng J 8 103-110... 

Han J, Qiu YZ, Liu DC, Chen GC (2004) Engineered Aeromonas hydrophila for enhanced production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) with alterable monomers composition. FEMS Microbiol Lett 239 195-201... 

Khanna S, Srivastava AK (2005b) Statistical media optimization studies for growth and PHB production by Ralstonia eutropha. Process Biochem 40 2173-2182 Khanna S, Srivastava AK (2007) Production of poly(3-hydroxybutyric-co-3-hydroxyvaleric aicd) having a high hydroxyvalerate content with valeric acid feeding. J Ind Microbiol Biotechnol 34 457-461... 

Qing TW, Yang ZM, Cai SX, Xu SR, Wu ZZ (1999) Interaction of cell adhesion to materieils in tissue engineering. Chin Reparative Reconstruct Suig 13 31-37 Qiu YZ, Han J, Chen GQ (2006) Metabolic engineering of Aeromonas hydrophila for the enhanced production of poly(3-hydroxybutyrate-co-3-hydioxyhexanoate). Appl Microbiol Biotechnol 69 537-542... 

Valentin HE, Dennis D (1997) Production of poly(3-hydroxybutyrate-co- 4-hydroxybutyrate) in recombinant Escherichia coli grown on glucose. J Biotechnol 58 33—38 Valentin HE, Lee EY, Choi CY, Steinbuchel A (1994) Identification of 4-hydroxyhexanoic acid as a new constituent of biosynthetic polyhydroxyalkanoic adds from bacteria, Appl Microbiol Biotechnol 40 710-716... 

Poly[3-hydroxybutyrate] was the first PHA to be produced on an industrial scale, but its brittle nature, its poor mechanical properties and its high production cost limited its application potential. In the early 1990s, Imperial Chemical Industries [ICI] started the production of poly[3-hydroxybutyrate-co-3-hydroxyvalerate] [P3HB3HV] under the trade name Biopol . This material showed lower degrees of crystallinity and superior mechanical properties. Later on, the production of Biopol was continued by Monsanto and subsequently followed up by Metabolix. PHAs were originally intended as bio-based alternatives for polyolefins used in plastic containers, films and bottles. Despite the large interest in PHAs, their application remains, however, limited due to their narrow processing window [84, 85]. 

Qiu, Y.-Z., Han, J., Guo, J.-J., Chen, G.-Q., Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from gluconate and glucose by recombinant Aeromonas hydrophlla and Pseudomonas putida. Biotechnoloov hpttp.rs. 18, 1381-1386 (2005), DOl 10.1007/sl0529-005-3685-6. 

G. Chen, G. Zhang, S. Park, S. Lee, Industrial scale production of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate), Appl. Microbiol. Biotechnol. 57 (1-2) (2001) 50-55. 

Multilayer co-extrusion is another technique used in the preparation of starch/ synthetic sheets or films [164, 263-266], in which TPS is laminated with appropriate biodegradable polymers to improve the mechanical, water-resistance and gas-barrier properties of final products. These products have shown potential for applications such as food packaging and disposable product manufacture. Three-layer co-extrusion is most often practiced, in which a co-extrusion line consists of two single-screw extruders (one for the inner starch layer and the other for the outer polymer layers) a feedblock a coat-hanger-type sheet die and a three-roll calendering system [164]. Biodegradable polyesters such as PCL [164, 264], PLA [164, 263], and polyesteramide, PBSA and poly(hydroxybutyrate-co-valerate) [164] are often used for the outer layers. These new blends and composites are extending the utilization of starch-based materials into new value-added products. 

The Production of Poly-3-hydroxybutyrate-co-3-hydroxyvalerate with Pseudomonas cepacia ATCC 17759 on Various Carbon Sources... 

Hiramitsu, M., Koyama, N. and Doi, Y., 1993, Production of poly(3-hydroxybutyrare-co-4-hydroxybutyrate) by Alcaligenes lotus. Biotechnol Lett., 15 461-464. 

Chen, C.W., Don, T.-M. and Yen, H.-F. (2006) Enzymatic extruded starch as a carbon source for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Haloferax mediterranei. Process Biochemistry, 41,2289-2296. 

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