Probable Lethal Dose for Humans

Toxicity rating Commonly used term LDso Single oral dose for rats (g/kg) 4hr Vapour exposure causing 2 to 4 deaths in 6-rat group (ppm) LDso Skin for rabbits (g/kg) Probable lethal dose for humans... 

Table 3. Detergent Animal Acute Oral Versus Probable Lethal Dose for a Human Adult ...

By ingestion, the mean lethal dose for humans probably lies between 120 and 180ml. Symptoms include burning pain in the mouth and throat, abdominal pain, nausea, vomiting, and occasionally diarrhea. Central nervous system effects are excitement, ataxia, confusion, and stupor. Convulsions may occur several hours after ingestion. Fever and tachycardia are common, and death is usually attributed to respiratory failure. ... 

The probable oral lethal dose for humans is in the range of 5-50 mg kg (between seven drops to one... 

Collodion is classified as moderately toxic. Probable oral lethal doses for humans are 0.5-5.0gkg or between 1 ounce and 1 pint (1 lb) for a 70 kg person. 

The LDlo (oral) for humans is 714pgkg . The American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value - time-weighted average (TLV - TWA) is 0.05 mgm . The probable lethal dose in humans is less than 5mgkg ... 

The results from this type of study are coupled with the second, very limited, source of toxicity data from previous chemical exposure records of workers. Chemicals are then classified in terms of their inferred, relative toxicity. The two extremes being practically non-toxic (probable lethal dose for a 70 kg human 15g/kg) to super toxic (probable lethal dose for a 70 kg human < 5 mg/kg) . ... 

Dioctyl sodium sulfosuccinate. Considered moderately toxic. Probable oral lethal dose for humans is 0.5-5 g/kg. If released to soil, the expected mobility of dioctyl sodium sulfosuccinate is from low to very high. If released to water, dioctyl sodium sulfosuccinate will be essentially nonvolatile. Dioctyl sodium sulfosuccinate has hydrolysis half-lives of 243 days at pH of 8 and 6.7 years at pH of 7. 

Toxicity rating Probable lethal oral dose for humans ... 

There is no information concerning toxic effects in humans, although the probable lethal oral dose for humans is 5-50mg/kg. 

Probable oral lethal dose for a human adult. 

Vanillin is a weak human sensitizer. It has induced skin sensitization in humans, and it was also reported to have highly irritating action on the eyes and mucous membranes of the respiratory tract. Ingestion of vanilla has provoked intolerance reaction it is pharmacologically active and may cause depressed blood pressure, increased respiratory rate, and even death due to cardiovascular collapse. Probable oral lethal dose to human is 500 mg kg for a 70 kg person. 

One of the most toxic organophosphorus insecticides highly toxic by oral route effects are cumulative toxic symptoms are similar to those of other cholinesterase inhibitors and include nausea, vomiting, diarrhea, excessive salivation, blurred vision and pain in eye muscle, convulsion, coma, and respiratory failure probable lethal dose is estimated to be 5-10 g for adult humans. 

Approximately 40-60 mg of nicotine (43) is a lethal dose for an adult human the LD50 i.v. in mouse is 0.3 mg/kg (Wink, 1993). This base is the main pharmacologically active component of tobacco smoke and probably is responsible for the addictive nature of cigarettes. The pharmacology of nicotine and other Nicotiana alkaloids has been reviewed (Fodor and Colasanti, 1985). Nicotine mimics acetylcholine and activates acetylcholine receptors (Wink, 1993). 

Toxicity Rating Probable Lethal Dose Experimental LD50 for a 70 kg Human Dose per kg of Body Weight... 

The scientists from the US Public Health Service also lacked the risk-assessment tools we rely on now to understand the implications of exposure to chemical substances. Based on the toxicological data available at the time, they estimated that the probable lethal dose of ONCB to a human was between 5 and 50 milligrams per kilogram (mg/kg) of body weight, or "between 7 drops and 1 teaspoonful for 150 Ib.-man [sic]. A clinically significant illness would be expected to result from 1/10 fhe probable lethal dose" [3, Appendix, p. 2]. They further calculated that the estimated daily dose would allow for a 467-fold factor of safety but concluded that, given the uncertainties, "it does not... 

Toxicity Rating Commonly Used Term Probable Human Lethal Dose for a 70-kg (150-lb) Man... 

Carbon black, according to the current International Agency for Research on Cancer evaluation, is possibly carcinogenic to humans (Group 2B). Graphite is not listed as a carcinogen. The probable oral lethal dose for a human is > 15 g/kg, that is, more than 1 kg for a 70 kg person. In the form of graphite, it can cause a dust irritation, particularly to the eyes. Some forms of carbon dust can cause irritation of eyes and mucous membranes. Old studies of the mortality of carbon plant workers linked carbon black to heart diseases. 

Human consumers of meat from 1080-killed ducks would probably not be adversely affected after eating an average cooked portion (Temple and Edwards 1985). Moreover, oven-baking or grilling at temperatures >200°C will cause breakdown of 1080. For example, if a mallard received a triple lethal dose of 1080, then a 1-kg mallard would contain an estimated 14.4 mg of 1080. A 70-kg human would have to consume 25.4 kg of poisoned duck flesh to receive a lethal dose, as judged by LD50 values of 4.8 mg/kg BW for mallards and 5 mg/kg BW for humans. Theoretically, consumption of only two whole ducks poisoned by 1080 may cause transient toxicity (Temple and Edwards 1985). 

The lethal oral dose in humans is probably around 100, but doses as low as 16 mg have reportedly been fatal whereas doses of 2 000 mg have been survived. After ingestion, effects usually occur within 10-30 minutes and include stiffness of the face and neck muscles and increased reflex excitability. Strychnine acts by altering nerve impulses in the spinal cord, resulting in a decreased threshold for stimulation, and, hence, a hyperexcitable state. Any sensory stimulus may produce a violent motor response that, in the early stages of intoxication, tends to be a coordinated extensor thrust and, in later stages, may be a tetanic convulsion with opisthotonos anoxia and cyanosis develop rapidly. Between convulsions, muscular relaxation is complete, breathing is resumed, and cyanosis lessens. Because sensation is unaffected, the convulsions are painful and lead to overwhelming fear. As many as 10 convulsions separated by intervals of 10-15 minutes may be experienced, but death often occurs after the second to fifth convulsion, and even the first convulsion may be fatal if sustained death is commonly due to asphyxia.If recovery occurs, it is remarkably prompt and complete despite the violence of the illness muscle soreness may persist for a number of days. ... 

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