Posttranscriptional regulation

In contrast to the other CYPs, with induction of CYP2E1, there is no increase in mRNA, and more than one mechanism may be involved. There is, however, an increase in enzyme protein, up to eightfold in animals exposed to inducers. Thus, it seems that there is posttranscriptional regulation. The suggested mechanisms are... 

Alternative Modes of mRNA Splicing Present a Potent Mechanism for Posttranscriptional Regulation Gene Expression Is Also Regulated at the Levels of Translation and Polypeptide Processing Patterns of Regulation Associated with Developmental Processes... 

Alternative Modes of mRNA Splicing Pr esent a Potent Mechanism for Posttranscriptional Regulation... 

Phenylpropanoid Biosynthesis in Plants Enzymology and Pathway Topology 491 Transcriptional and Posttranscriptional Regulation of Phenylpropanoid Biosynthesis in Plants 504... 

Transcriptional and Posttranscriptional Regulation of Phenylpropanoid Biosynthesis in Plants... 

Parks, W. C. (1997). Posttranscriptional regulation of lung elastin production. Am. J. Respir. Cell Mol. Biol. 17, 1-2. 

Zhang, M., Pierce, R. A., Wachi, H., Mecham, R. P., and Parks, W. C. (1999a). An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor (31. Mol. Cell. Biol. 19, 7314-7326. 

Yano, M., Okano, H. J., Okano, H. (2005). Involvement of Hu and linRNP K in neuronal differentiation through p21 mRNA posttranscriptional regulation. J. Biol. Chem. 280, 12690-12699. 

Most experimental data were derived from rodent models in which drug transporter regulation occurs mostly at the transcriptional level. Posttranscriptional regulation (e.g., targeting and retrieval of transporters from membranes), however, seems to be important in humans also [93, 94]. 

Worgall TS, Juliano RA, Seo T, Deckelbaum RJ. Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. Arterios-cler Thromb Vase Biol 24(2004a) 943-948. 

Hsieh, C. C., Xiong, W., Xie, Q., Rabek, J. P., Scott, S. G., An, M. R., Reisner, P. D., Kuninger, D. T., and Papaconstantinou, J. Effects of age on the posttranscriptional regulation of CCAAT/enhancer binding protein alpha and CCAAT/enhancer binding protein beta isoform synthesis in control and LPS-treated livers. Mol Biol Cell 9 (1998)... 

Agellon, L.B., Cheema, S.K. 1997. The 3 -untranslated region of the mouse cholesterol 7a-hydroxylase contains elements responsive to posttranscriptional regulation by bile acids. Biochem. J. 328 393-399. 

Gryczan, T., Grandi, G., Hahn, J., Grandi, R., and Dubnau, D. (1980). Conformational alteration of mRNA structure and the posttranscriptional regulation of erythromycin-induced drug... 

Figure 8-2 Posttranscriptional regulation by IRE/IRP interactions. In iron-replete cells, IRPs do not bind to IREs. Iron starvation induces IRPs to bind to their ligands, resulting in stabilization of transferrin receptor mRNA and translational inhibition of the mRNAs encoding ferritin H- and L-chain), eALAS and mitochondrial aconitase.

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